We are seeking an experienced Senior Clinical Development Medical Director who will be involved across the full scope of dermatology and autoimmune clinical drug development activities from discovery research through first in human, POC, and Phase 3 studies. The role will include leadership of one or more studies within the portfolio and will work closely with all members of the cross-functional asset team, to apply full clinical knowledge to successfully advance clinical programs as well as the overall asset strategy.

Responsibilities

• Broadly represent the interests of Alumis as a senior leader and spokesperson for Clinical Development within the fields of Dermatology and Immunology
• Provide leadership in the management and oversight of the global ESK-001 Phase 3 program in plaque psoriasis, leading one or more studies
• Effectively contribute to cross-functional teams within Research, Biomarkers, Medical Affairs, Commercial, and Study Team as an expert within the Dermatology therapeutic area and broadly across immune mediated inflammatory diseases
• Support the clinical Science function contributing to the design and development of novel clinical studies and cross-functional initiatives
• Provide strategic support and implement clinical strategies across early and late stage clinical development programs
• Coach, manage, inspire, and support team members to achieve business goals by leveraging an entrepreneurial and collaborative mindset
• Maintain the highest levels of integrity within development and standards for scientific inquiry in drug development
• Collaborate with CRO to provide medical monitoring oversight for the Phase 3 program
• Support the planning and execution of publication plan and data generation, as well as submission activities

Qualifications:

• MD or ex-US equivalent with board certification or eligibility in Dermatology or in a related immunology disease area with > 5 years of drug development experience (data review, CRF query handling, medical monitoring, writing papers)
• Notable communication skills with credibility to interface with Key Opinion Leaders, external health organizations and regulators within Dermatology
• Ability to interact effectively in a cross-functional setting
• Strong interpersonal, influencing, presentation, and communications skills (written and verbal) to effectively address all levels within an organization
• Ability to assess, understand, and communicate continuously expanding medical and scientific information, as well as knowledge of commercial dynamics impacting drug development
• Strong business acumen and ability to collaborate with cross-functional partners to achieve enterprise goals
• Effective negotiation skills that enable the candidate to influence without authority
• Proven professional track record of strategic, organizational, and executional skills to support project planning across multiple activities, with the ability to anticipate and prioritize one’s workload across multiple projects of equal importance
• Ability to work across diverse teams in a matrixed organizational structure, both as a leader and as part of a cross-functional team
• Approaches deliverables in an organized manner with attention to detail and is able to meet timelines in a fast-paced environment
• Able to work autonomously and with a high level of independence

The salary range for this position is $325,000 USD to $358,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite once a month.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.

We are seeking an experienced Senior Medical Director in Clinical Development who will be involved across the full scope of rheumatology and autoimmune clinical drug development activities from discovery research through first in human, POC, and Phase 3 studies. The role will include leadership of one or more studies within the portfolio and will work closely with all members of the cross-functional asset team, to apply full clinical knowledge to successfully advance clinical programs as well as the overall asset strategy.

Principal Responsibilities 

• Serve as the physician lead for LUMUS, a 388-patient Phase 2b clinical trial designed to evaluate the efficacy, safety, and pharmacokinetics of multiple doses of ESK-001 in adult patients with moderately to severely active, autoantibody-positive SLE. 
• Provide leadership of in-stream data reviews and reconciliation efforts. 
• Hold authorship of clinical portions of key study documents, such as Protocol Amendments and Regulatory Submissions. 
• Provide oversight of the LUMUS medical monitor. • Participates in external scientific engagement, including peer-to-peer interactions with MDs. 
• Broadly represent the interests of Alumis as a leader, supporting corporate initiatives across rheumatology.
• Coach, manage, inspire, and support team members to achieve goals by leveraging a focused and collaborative mindset. 
• Maintain the highest levels of integrity and standards for scientific inquiry in drug development. 

Primary Goals During the opening months on the job, this Senior Medical Director will be expected to focus on the following objectives: 

1. Earn the full trust and respect of key internal and external stakeholders by establishing a reputation as a strategic and highly productive partner.

2. Provide hands-on leadership, apply knowledge and expertise, and partner seamlessly with the operations team to help make LUMUS thrive.

3. Focus on improving and maintaining study data quality, including cross-referencing of the main efficacy endpoints.

Candidate Requirements

• MD (or ex-US equivalent) with board certification in Rheumatology.
•  5+ years of clinical development experience; having a background in lupus clinical trials is desired.
•  Proven leadership skills, as evidenced by having managed people within a pharmaceutical company or in a clinical/academic environment.
•  Ability to assess, understand, and communicate continuously expanding medical and scientific information.
•  Proven professional track record of strategic, organizational, and executional skills to support project planning across multiple activities, with the ability to anticipate and prioritize one’s workload across multiple projects of equal importance.
•  Proven ability to approach deliverables in an organized manner with attention to detail and to meet timelines in a fast-paced environment.
•  Established ability to work across diverse teams in a matrixed organizational structure, both as a leader and as part of a cross-functional team.
•  Strong interpersonal, influencing, presentation, and communications skills (both written and verbal) to effectively address all levels within an organization.
•  Ability to work autonomously and with a high level of independence.
•  Willingness to travel to Alumis’ HQ in South San Francisco for one week out of every month

The salary range for this position is $300,000 USD to $358,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite once a month.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. 

Position Summary

Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies evaluating envudeucitinib and A-005 across new indications identified for expansion of the Alumis pipeline. This high-impact role will be instrumental in shaping the company's clinical development portfolio, from indication selection through proof-of-concept studies, and will serve as a key scientific leader interfacing with internal teams, regulatory authorities, and the external medical community.

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Key Responsibilities

Clinical Development Strategy & Leadership

· Lead the design, planning, and execution of Phase 1 and Phase 2 clinical studies for A-005 and additional pipeline molecules in new therapeutic indications

· Develop and refine clinical development plans, including study synopses, protocols, and integrated development strategies for new indications

· Provide clinical and scientific leadership to cross-functional study teams, ensuring alignment on program goals, timelines, and deliverables

· Collaborate with Translational Medicine and Research teams to evaluate and prioritize new indication opportunities based on scientific rationale, competitive landscape, and unmet medical need

Study Execution & Oversight

· Serve as the Medical Monitor for assigned Phase 1 and 2 studies, ensuring patient safety and scientific integrity

· Oversee medical aspects of study conduct, including safety surveillance, protocol amendments, and data review

· Partner with Clinical Operations, Biostatistics, and Regulatory Affairs to ensure efficient study execution and high-quality data generation

· Lead interactions with Data Safety Monitoring Boards (DSMBs) and provide medical input for safety analyses

Regulatory & External Engagement

· Contribute to regulatory strategy and serve as a clinical representative in interactions with FDA and international regulatory authorities (EMA, PMDA, etc.)

· Prepare and review clinical sections of regulatory submissions, including IND amendments, briefing documents, and meeting packages

· Represent Alumis at scientific conferences, advisory boards, and with Key Opinion Leaders (KOLs) to advance clinical programs and gather external insights

· Build and maintain relationships with investigators, academic collaborators, and the broader medical community

Cross-Functional Collaboration

· Work closely with Translational Sciences, Biomarker, and Pharmacology teams to integrate biomarker strategies into clinical study designs

· Collaborate with Commercial and Medical Affairs teams on disease landscape assessments and indication prioritization

· Provide clinical expertise to support business development activities, including evaluation of potential partnerships or in-licensing opportunities

Team Development

· Mentor and develop junior medical staff, fostering a culture of scientific excellence and collaboration

· Contribute to building Alumis's clinical development capabilities as the organization grows

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Required Qualifications

· MD required; board certification or fellowship training in Rheumatology, Dermatology, or a related specialty strongly preferred

· 10+ years of pharmaceutical/biotechnology industry experience in clinical development, with a significant focus on immunology or autoimmune diseases

· Demonstrated experience leading Phase 1 and Phase 2 clinical studies from design through data readout

· Track record of successful regulatory interactions (FDA, EMA) and experience preparing IND/CTA submissions

· Deep understanding of early clinical development, including dose-finding strategies, biomarker integration, and adaptive trial designs

· Strong scientific acumen with the ability to critically evaluate preclinical and clinical data to inform development strategy

· Experience with JAK/TYK2 inhibitors or related immunomodulatory mechanisms preferred

· Excellent leadership, communication, and interpersonal skills with the ability to influence cross-functional teams in a matrixed environment

· Strategic mindset with demonstrated ability to balance scientific rigor with business objectives

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Preferred Qualifications

· Experience with indication expansion or lifecycle management for immunology assets

· Prior experience at a small or mid-sized biotechnology company; comfort operating in a fast-paced, resource-conscious environment

· Established relationships with KOLs in rheumatology, dermatology, or gastroenterology

· Experience with multiple autoimmune indications (e.g., psoriasis, psoriatic arthritis, lupus, atopic dermatitis, CNS inflammatory and degenerative diseases)

· Familiarity with regulatory pathways for expedited development (Breakthrough Therapy, Fast Track)

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Travel Requirements

Travel required (approximately 20-30%) to support investigator meetings, scientific conferences, regulatory interactions, and site visits.

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The salary range for this position is $300,000 USD to $400,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices.

This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Remote candidates will be considered on a case-by-case basis.

Alumis Inc. is an equal opportunity employer.

Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program.  

Other benefits include:

• Health insurance premiums paid at 90% for employee, 80% for dependents
• Free access to Genentech Bus & Ferry Share program
• $100 monthly cell phone stipend
• Unlimited PTO for Exempt employees
• Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to elevate, challenge and nurture one another along the way.