We are seeking a Scientist II to join the Reagent Sustaining and Applications group to lead sustaining efforts for our Chromium Single Cell products. The role interfaces with R&D, Production, Marketing, and Support to provide the best products to our customers from pre-launch to end of life. 

The ideal candidate should have expertise in product development, troubleshooting complex issues, and understanding of molecular biology, including single cell assays, reagent manufacturing, and developing assays for quality control or manufacturing environments.

What you will be doing:

• Lead efforts in testing new materials, tools, and workflows to improve 10x’s state-of-the-art products.
• Collaborate with key internal and external partners to troubleshoot and mitigate any issues that may arise in 10x’s Chromium product line.
• Design and execute experiments to assess the impact of protocol, reagent, or process changes on 10x’s Assays.
• Perform statistical analyses on key assay and QC metrics.
• Update manufacturing documents and present results.

Minimum Qualifications:

• BS, MS, or PhD in molecular biology, biochemistry, genetics, microbiology, analytical chemistry, or related fields.
• 8+ years (BS), 5+ years (MS) or 3+ years (PhD) of relevant experience in reagent or assay development and optimization, preferably in the Biotechnology industry.
• Experience analyzing large-scale single-cell or spatial transcriptomics datasets to derive biologically meaningful insights and/or diagnostic biomarkers.
• Ability to design and execute experiments to measure the impact of process improvements and/or formulation changes.
• Experience with a broad variety of molecular biology and analytical techniques including qPCR, nucleic acid isolation, use of plate readers, Bioanalyzers, gel imagers, real-time PCR instruments, etc.
• Experience with single cell assays including cell handling, library preparation and downstream analysis.
• Experience investigating, identifying, documenting, communicating, and resolving quality control issues in a controlled manufacturing environment.
• Experience defining, documenting, communicating, and transferring new manufacturing workflows into controlled manufacturing environments.
• Meticulous attention to detail and a conscientious work ethic.

Preferred Qualifications: 

• Hands-on experience with the 10x Chromium platform.
• Experience using statistical tools, such as JMP or R to analyze complex data sets, create DOE experiments, and create data trending reports.
• Experience with bioinformatic analysis of Next Generation Sequencing data from Illumina platforms.

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About the role:

10x is looking for an outstanding Senior Scientist to join the Process Development team to support the development and commercial launch of new products. The candidate will work cross-functionally with Chemistry, Microfluidics, custom plastic consumables, Assay Development, and Production teams to develop, optimize, validate, and transfer new chemistries and processes required to produce 10x reagents and consumables. Candidates must have a broad working knowledge of chemical processes and analytical methods related to polymer, surfactant, or surface chemistry and experience in the use of custom instrumentation. Hands on experience in process development, scale-up, process implementation and validation in a commercial manufacturing facility is a plus.

Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast-paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.

What you will be doing:

• Act as a technical lead to develop, optimize and support a broad range of chemistry-based production processes through use of custom equipment, optical imaging, and analytical testing.
• Develop a deep understanding of the interplay between chemistry, microfluidics, production processes, and molecular biology to identify the root cause of product deviations, troubleshoot them, and identify and implement solutions.
• Plan and execute experiments, maintain an accurate record of experimental details, in-depth data analysis, and clear communication of these results through documentation and presentations.
• Write protocols, develop procedures, and maintain accurate records.
• Communicate and present results clearly and contribute data for making critical design decisions
• Job may require 10% international travel

 Minimum Requirements:

• Ph.D. in Chemical Engineering, Organic Chemistry, Polymer Chemistry, Surface Chemistry, and 4+ years of industry experience
• Ability to integrate a broad range of scientific and engineering disciplines.
• Ability to design meaningful experiments and in-depth analysis of results. Experience using statistical tools for process control.
• Good documentation skills and ability to communicate experimental design, results and plans through presentations and reports.
• Understanding of physical chemical principles to scale up chemical manufacturing processes.
• Ability to develop, validate and transfer processes to manufacturing or OEM vendors.
• Strong collaboration and communication skills.
• Desire to be part of a rapidly evolving organization, with a compelling technology, and taking products and processes to the next level.

  Preferred Skills and Qualifications:

• Experience with automation equipment or custom instrumentation.
• Experience developing plastic consumables for microbiology applications.
• Successfully developed and transferred processes in the life science industry.
• Managed a multidisciplinary team to develop a product, transfer a process or solve a manufacturing issue.
• Experience using statistical tools for process control.

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