The Opportunity:

We are looking for motivated structural biologist to join tour team to support multiple oncology therapeutic programs. The ideal candidate will have previous, hands-on experience in sample preparation, data acquisition and data analysis from both X-ray crystallography and cryo-EM. They will apply their expertise to form compound driven complexes, identify, and optimize crystallization/CryoEM conditions with the aim of determining high resolution structural information to drive small molecule design and mechanistic understanding. We’re seeking a team player with enthusiasm to work in an interdisciplinary setting to drive toward new, cutting edge oncology therapeutics. 

Responsibilities

• Plan and execute experiments with the aim of determining small molecule driven multi-protein complex structures by CryoEM and X-ray crystallography.

• Perform cryo-EM grid screening, optimization, data collection and refinement to enable high-quality structure determination.

• Interact with interdisciplinary teams (including chemists, computational chemists, biologists, project teams, and management) and clearly articulate structural data in a broader drug discovery context.

• Maintain excellent records and communication among internal and external colleagues.

• Be driven by a desire to be innovative in a high energy, fast paced environment and work collaboratively with a variety of collegues across the organization.

Required Skills, Experience and Education:

• PhD in structural biology or protein biochemistry or a related scientific discipline with 2-5 years of post-doctoral experience.

• Hands-on experience and expertise in cryo-EM sample optimization and grid preparation, data collection, map generation, and structure determination.

• Strong track record of solving challenging CryoEM problems such as preferred orientation, small proteins/complexes, modeling into low resolution maps, or iterative rounds of protein optimization.

• Hands on experise with modern software packages for data collection, refinement and visualization of structural biology data, and the ability to seamless switch between them based on need (e.g. CryoSPARC, RELION, Phenix, REFMAC, Coot, ChimeraX, Pymol).

• Excellent written, verbal communication, interpersonal and organization skills.

• Conscientious team-player interested in a fast-paced biotech environment.

Preferred Skills:

• Hands-on experience and expertise in protein crystallization, crystal optimization and harvesting for data collection.

• Experience with biophysical characterization methods, including mass spectrometry, SEC-MALS, DLS, SPR, NMR and thermal shift assays.

• Experience with protein-protein complexes including antibodies/Fabs, molecular glues, PROTACs, etc.

• Experience working in a multidisciplinary team environment.

• Experience in gene construct design, expression and purification of recombinant proteins. 

  #LI-Hybrid  #LI-LN1

ESA is seeking a mid-level biologist with 2-7 years of experience in relevant scientific or environmental consulting environment.  This is an exempt, full-time, salaried role with hybrid flexible expectations. Qualified candidates must be located in the San Francisco Bay Area, vicinity of Sacramento, Sacramento-San Joaquin River Delta, Central Valley, or within 3 hours commute.  All qualified candidates must be willing & able to travel as needed. Preference given to candidates located in the bay area and central valley of CA. This role involves travel for site visits, projects, and in-person team collaboration as needed.

Who You Are 

• Qualified candidates should have previous experience performing natural resource-related evaluations, technical studies, analyses and tasks requiring knowledge based on education and at least two years of professional experience. 
• Previous construction compliance monitoring experience required.
• Qualified candidates must demonstrate the ability to perform all aspects of biological monitoring on small to large, complex construction projects. Some night and/or weekend work may be assigned. General experience with wildlife and vegetation species from the geographic area of work: California Central Valley and San Francisco Bay Area.
• Qualified candidates must have experience surveying and monitoring CA nesting birds. 
• Preference given to candidates with direct experience surveying, handling, and monitoring for, or with monitoring approvals by state and federal agencies for one or more of the following species: San Joaquin kit fox, California tiger salamander, California red-legged frog, northwestern pond turtle, San Francisco garter snake, giant garter snake, California black rail, western burrowing owl, western spadefoot, vernal pool brachiopods, Swainson’s hawk and/or other nesting birds, Crotch’s bumble bee, and bats.
• You enjoy fieldwork and can walk long distances carrying a backpack; and are able to lift at least 50 pounds. You are confident working outside, in remote and rural settings, as well as in urban environments. Physical outdoor work may include, but may not be limited to, work in all types of weather, traversing uneven ground and sometimes steep terrain in vegetated environments, agricultural fields, arid lands, and along stream banks. You may be exposed to inclement weather and uncomfortable working conditions. Some early morning, late night and/or weekend work, as well as long hours may be required
• Must possess a valid driver’s license and have own transportation to project sites
• Must have a smart phone with sufficient data plan to collect necessary data on-site

What You Will Do for ESA

• Perform biological compliance monitoring and reporting at active construction sites to ensure conformance with environmental/permit requirements
• Conduct special-status species surveys and nesting bird surveys
• Construction compliance monitoring
• Identify and may relocate sensitive species, when needed and if agency-approved
• Effectively communicate with senior ESA staff, construction crews, project personnel, and project management staff
• Take initiative and contribute to a respectful, feedback-driven team culture
• Maintain daily written monitoring and inspection logs, including utilizing electronic data collection tools, such as Fulcrum and Trello
• Enter data into an on-line GIS mapping application, such as Fieldmaps, Collector, Survey 123
• Deliver worker environmental awareness training to on-site staff
• Comply with all safety requirements and policies
• Field work outside, potentially in remote or rural settings, as well as in urban environments.
• Desk-based data processing, technical evaluations, and a range of client deliverables
• Training/mentoring early career biologists
• Other ad hoc tasks as needed

What’s Special About Our Biology Team

Our Biology Team includes biologists, restoration ecologists, permitting specialists, conservation biologists, and environmental scientists that provide expertise for many municipalities throughout California. Our work matters because it helps communities shape a positive future for their citizens in balance with conserving our state’s sensitive natural resources. We value creative thinking, teamwork, and multi-disciplinary and cross-disciplinary engagement and integration. 

We encourage you to read about some of the exciting projects we have recently completed. 

What’s Special About ESA

Joining ESA means becoming part of a close-knit team of environmental professionals who contribute to outstanding projects, improve environmental stewardship, and advance a more sustainable and resilient future for our communities and wild places.

At ESA, we provide benefits such as medical, dental, and vision insurance (paid at 70% for you AND your family), annual allocations of company share through our ESOP, a 401(k) plan with company match, and paid vacation, sick leave, and holidays, to name a few.

We also provide specific programs whether you want to further your technical expertise, sharpen your business acumen, or help lead the next generation of employee-owners. We want to support you in reaching your career goals through tuition reimbursement, professional development bonuses, and attendance at conferences.

About the Role

We are seeking an exceptional Staff Computational Biologist to drive the next generation of software and data products supporting Target Identification and Prioritization across our research organization. This hybrid role is ideal for someone who thrives at the intersection of biology, computation, product strategy, and engineering execution.

As a senior member of the Translational Platform Engineering team, you will act as a product owner, technical strategist, and rapid prototyper, responsible for shaping the roadmap and delivering tools that power discovery teams. Your day to day includes working with biology data scientists to harden their notebooks and workflows, pushing new releases to production (on a predictable schedule), and sitting with biologists and chemists as they use the UIs to advance our translational biology efforts. The Staff Computational Biologist is the key to translating use cases into technical specifications for engineering teams.

This is a highly visible and impactful role where you will contribute to a human-biology-first approach to drug discovery programs by leading the end-to-end lifecycle of platform capabilities used daily by our Target ID scientists.

What You’ll Do…

• Own the product roadmap for Target ID software.
• Gather and prioritize scientific requirements from internal users.
• Translate use cases into technical specifications for engineering teams.
• Rapidly prototype computational solutions using Python.
• Develop and maintain internal packages, reproducible workflows, and APIs.
• Establish documentation, onboarding materials, and best practices for internal platform usage.
• Lead cross-functional project execution (data engineering, software engineering).
• Follow good engineering practices (i.e. CI/CD, predictable demo cadence, etc.)

What You Bring...

• Bachelor's/ Master's degree in relevant field (computational biology, bioinformatics, systems biology, computer science) or equivalent relevant education and experience
• 6+ years industry experience in computational biology or data-driven discovery; minimum 1 years’ experience in software engineering and data engineering teams
• Proficiency working with programming languages Python, and R, modern development frameworks and developing internal packages
• Experience with omics/translational data analysis, scalable ETL pipelines, data modeling, and associated QC
• 1+ years’ experience leading complex projects as product owner
• Experience supporting target identification, prioritization, or multi-modal analysis.

Nice to have...

• Experience with dashboard development (e.g. Shiny, Dash, Streamlit, React, Veu.js).
• Understanding of cloud-native tools and modern data platforms (AWS/GCP/Azure).
• Familiarity with the drug discovery and development process is a plus

ESA is seeking variable part-time (on-call) field biologists with 5+ years' experience. Qualified candidates must be located in the San Francisco Bay Area, vicinity of Sacramento, Sacramento-San Joaquin River Delta, Central Valley, or within 3 hours.  All qualified candidates must be willing & able to travel as needed. Preference given to candidates located in the bay area and central valley of CA.  The need for on-call services is expected to be greatest in late summer through fall with periodic work throughout other parts of the year. Additional work beyond this period may be requested. 

Who You Are 

• Qualified candidates should have previous experience performing natural resource-related evaluations, technical studies, analyses and tasks requiring knowledge based on education and at least two years of professional experience. 
• Previous construction monitoring experience required.
• Qualified candidates must demonstrate the ability to perform all aspects of biological monitoring on small to large, complex construction projects. Some night and/or weekend work may be assigned. General experience with wildlife and vegetation species from the geographic area of work: California Central Valley and San Francisco Bay Area.
• Qualified candidates must have experience surveying and monitoring CA nesting birds. 
• Preference given to candidates with direct experience surveying, handling, and monitoring for, or with monitoring approvals by state and federal agencies for one or more of the following species: San Joaquin kit fox, California tiger salamander, California red-legged frog, northwestern pond turtle, San Francisco garter snake, giant garter snake, California black rail, western burrowing owl, western spadefoot, vernal pool brachiopods, Swainson’s hawk and/or other nesting birds, Crotch’s bumble bee, and bats.
• You enjoy fieldwork and can walk long distances carrying a backpack; and are able to lift at least 50 pounds. You are confident working outside, in remote and rural settings, as well as in urban environments. Physical outdoor work may include, but may not be limited to, work in all types of weather, traversing uneven ground and sometimes steep terrain in vegetated environments, agricultural fields, arid lands, and along stream banks. You may be exposed to inclement weather and uncomfortable working conditions. Some early morning, late night and/or weekend work, as well as long hours may be required

What You Will Do for ESA

Preference will be given to candidates with direct experience surveying, handling, and monitoring for, or with monitoring approvals by state and federal agencies for one or more of the following species: San Joaquin kit fox, California tiger salamander, California red-legged frog, northwestern pond turtle, San Francisco garter snake, giant garter snake, California black rail, western burrowing owl, western spadefoot, vernal pool brachiopods, Swainson’s hawk and/or other nesting birds, Crotch’s bumble bee, and bats. Successful candidates will fulfill the following duties:

• Perform biological compliance monitoring and reporting at active construction sites to ensure conformance with environmental/permit requirements
• Conduct special-status species surveys and nesting bird surveys
• Identify and may relocate sensitive species, when needed and if agency-approved
• Effectively communicate with senior ESA staff, construction crews, project personnel, and project management staff
• Take initiative and contribute to a respectful, feedback-driven team culture
• Maintain daily written monitoring and inspection logs, including utilizing electronic data collection tools, such as Fulcrum and Trello
• Enter data into an on-line GIS mapping application, such as Fieldmaps, Collector, Survey 123
• Deliver worker environmental awareness training to on-site staff
• Must possess a valid driver’s license and have own transportation to project sites
• Must have a smart phone with sufficient data plan to collect necessary data on-site
• Comply with all safety requirements and policies
• Able to lift up to 40 pounds
• Confident in working outside, potentially in remote or rural settings, as well as in urban environments.
• Other ad hoc tasks as needed

What’s Special About Our Biology Team

Our Biology Team includes biologists, restoration ecologists, permitting specialists, conservation biologists, and environmental scientists that provide expertise for many municipalities throughout California. Our work matters because it helps communities shape a positive future for their citizens in balance with conserving our state’s sensitive natural resources. We value creative thinking, teamwork, and multi-disciplinary and cross-disciplinary engagement and integration. 

We encourage you to read about some of the exciting projects we have recently completed. 

What’s Special About ESA

Joining ESA means becoming part of a close-knit team of environmental professionals who contribute to outstanding projects, improve environmental stewardship, and advance a more sustainable and resilient future for our communities and wild places.

You are eligible to participate in ESA’s sick leave program. You may be eligible to participate in our employee stock ownership program and tax deferred 401(k) plan if you meet the eligibility requirements for these plans.

ESA is seeking variable part-time (on-call) field biologists with 0-5 years experience.  Preference given to candidates with 1+ years of professional experience. Qualified candidates must be located in the San Francisco Bay Area, vicinity of Sacramento, Sacramento-San Joaquin River Delta, Central Valley, or within 3 hours.  All qualified candidates must be willing & able to travel as needed. Preference given to candidates located in the bay area and central valley of CA.  The need for on-call services is expected to be greatest in late summer through fall with periodic work throughout other parts of the year. Additional work beyond this period may be requested. 

Who You Are 

• Qualified candidates should have previous experience performing natural resource-related evaluations, technical studies, analyses and tasks requiring knowledge based on education and at least two years of professional experience. 
• Previous construction monitoring experience required.
• Qualified candidates must demonstrate the ability to perform all aspects of biological monitoring on small to large, complex construction projects. Some night and/or weekend work may be assigned. General experience with wildlife and vegetation species from the geographic area of work: California Central Valley and San Francisco Bay Area.
• Qualified candidates must have experience surveying and monitoring CA nesting birds. 
• Preference given to candidates with direct experience surveying, handling, and monitoring for, or with monitoring approvals by state and federal agencies for one or more of the following species: San Joaquin kit fox, California tiger salamander, California red-legged frog, northwestern pond turtle, San Francisco garter snake, giant garter snake, California black rail, western burrowing owl, western spadefoot, vernal pool brachiopods, Swainson’s hawk and/or other nesting birds, Crotch’s bumble bee, and bats.
• You enjoy fieldwork and can walk long distances carrying a backpack; and are able to lift at least 50 pounds. You are confident working outside, in remote and rural settings, as well as in urban environments. Physical outdoor work may include, but may not be limited to, work in all types of weather, traversing uneven ground and sometimes steep terrain in vegetated environments, agricultural fields, arid lands, and along stream banks. You may be exposed to inclement weather and uncomfortable working conditions. Some early morning, late night and/or weekend work, as well as long hours may be required

What You Will Do for ESA

• Perform biological compliance monitoring and reporting at active construction sites to ensure conformance with environmental/permit requirements
• Conduct special-status species surveys and nesting bird surveys
• Identify and may relocate sensitive species, when needed and if agency-approved
• Effectively communicate with senior ESA staff, construction crews, project personnel, and project management staff
• Take initiative and contribute to a respectful, feedback-driven team culture
• Maintain daily written monitoring and inspection logs, including utilizing electronic data collection tools, such as Fulcrum and Trello
• Enter data into an on-line GIS mapping application, such as Fieldmaps, Collector, Survey 123
• Deliver worker environmental awareness training to on-site staff
• Must possess a valid driver’s license and have own transportation to project sites
• Must have a smart phone with sufficient data plan to collect necessary data on-site
• Comply with all safety requirements and policies
• Able to lift up to 40 pounds
• Confident in working outside, potentially in remote or rural settings, as well as in urban environments.
• Other ad hoc tasks as needed

What’s Special About Our Biology Team

Our Biology Team includes biologists, restoration ecologists, permitting specialists, conservation biologists, and environmental scientists that provide expertise for many municipalities throughout California. Our work matters because it helps communities shape a positive future for their citizens in balance with conserving our state’s sensitive natural resources. We value creative thinking, teamwork, and multi-disciplinary and cross-disciplinary engagement and integration. 

We encourage you to read about some of the exciting projects we have recently completed. 

What’s Special About ESA

Joining ESA means becoming part of a close-knit team of environmental professionals who contribute to outstanding projects, improve environmental stewardship, and advance a more sustainable and resilient future for our communities and wild places.

You are eligible to participate in ESA’s sick leave program. You may be eligible to participate in our employee stock ownership program and tax deferred 401(k) plan if you meet the eligibility requirements for these plans.

Join Our Thriving Talent Community!

Are you passionate about protecting our planet and advancing environmental science? Whether you're a biologist, planner, scientist, or environmental professional, we invite you to join our vibrant Talent Community!

Why Join Us?

• Networking Opportunities: Connect with industry leaders and peers to share insights, collaborate on projects, and expand your professional network.
• Career Growth: Access exclusive job opportunities, career development resources, and mentorship programs designed to help you advance in your career.
• Innovative Projects: Be part of groundbreaking projects that push the boundaries of sustainability, conservation, and environmental technology.
• Continuous Learning: Stay ahead of the curve with access to the latest industry trends, webinars, workshops, and certifications.
• Culture: ESA culture is built on inclusion, creativity, collaboration, and a commitment to our work, our clients, and our communities.

Get Involved!

• Join Our Events: Visit us and get to know us during our regular events, and conferences to stay connected and inspired.
• Share Your Expertise: Contribute to our community by sharing your knowledge, experiences, and innovative ideas.
• Stay Updated: Follow us on social media and subscribe to our newsletter for the latest news, job postings, and industry insights.

Take Action Today!

Join our Environmental Science Talent Community and be a part of the movement towards a sustainable future. Together, we can make a difference. Click the Apply button above to sign up and start your journey with us!