Machine Learning Engineer - LLMs & Generative AI

Truveta is the world’s first health provider led data platform with a vision of Saving Lives with Data. Our mission is to enable researchers to find cures faster, empower every clinician to be an expert, and help families make the most informed decisions about their care. Achieving Truveta’ s ambitious vision requires an incredible team of talented and inspired people with a special combination of health, software and big data experience who share our company values.

This position is based out of our headquarters in the Greater Seattle area.  #LI-hybrid

Who We Need 

Truveta is building a diverse and inclusive team to tackle complex health and technical challenges. We are seeking enthusiastic new graduates who are problem-solvers, collaborative teammates, and eager to make a difference in healthcare. If you’re excited about purposeful work, joining a mission-driven team, and launching your career in a supportive environment, Truveta could be the perfect place to start.

This Opportunity 

We are looking for a Machine Learning Engineer with a deep background in generative AI, large language models (LLMs), and reinforcement learning techniques to build the next generation of AI systems for trustworthy healthcare. This role offers a unique opportunity to build foundational models trained on vast clinical data and drive innovation in a highly meaningful domain.

Responsibilities

• Lead the development, training, and deployment of large language and multimodal foundation models tailored to clinical and biomedical domains.
• apply and refine state-of-the-art techniques such as supervised fine-tuning (SFT), reinforcement learning-based methods (e.g., RLHF, RLVR), parameter-efficient fine-tuning (PEFT), prompt tuning, and retrieval-augmented generation (RAG).
• Collaborate cross-functionally with researchers, clinicians, and engineers to design ML-driven solutions that improve healthcare delivery and outcomes.
• Build scalable infrastructure for distributed training of large models (TPU/GPU clusters, multi-node orchestration).
• Design and evaluate models for robustness, bias mitigation, factual consistency, and explainability in healthcare contexts.
• Stay current with the latest research in generative AI and contribute back to the community through publications and open-source initiatives.

Minimum Qualifications

• 6+ years of experience in software engineering or machine learning (3+ years with a PhD).
• Experience designing and training LLMs or large-scale generative models (e.g., GPT, PaLM, LLaMA, Claude, Gemma).
• Deep expertise in NLP, sequence modeling, and transformer architectures.
• Proficient in Python and ML libraries such as PyTorch or TensorFlow; strong engineering skills in building scalable ML pipelines.
• Experience with RL-based fine-tuning (e.g., Reinforcement Learning from Human Feedback) and evaluation of generative systems.
• Proven ability to lead technical projects and collaborate across teams.
• Bachelor's degree in Computer Science, Engineering, or a related technical field

Preferred Qualifications

• PhD or equivalent experience in Machine Learning, NLP, AI, or a related field.
• Experience in healthcare, biomedical informatics, or clinical data modeling.
• Familiarity with multi-modal foundation models (e.g., text-image, text-structured data) and cross-modal alignment techniques.
• Hands-on experience with vector databases, semantic search, and retrieval-based generation
• Publications in top-tier ML conferences (NeurIPS, ICML, ACL, EMNLP, ICLR, etc.).
• Experience building trustworthy AI systems and applying model interpretability, fairness, and safety frameworks.

Why Truveta?

Be a part of building something special. Now is the perfect time to join Truveta. We have strong, established leadership with decades of success. We are well-funded. We are building a culture that prioritizes people and their passions across personal, professional, and everything in between. Join us as we build an amazing company together.

We Offer:

• Interesting and meaningful work for every career stage
• Great benefits package
• Comprehensive benefits with strong medical, dental and vision insurance plans
• 401K plan
• Professional development & training opportunities for continuous learning
• Work/life autonomy via flexible work hours and flexible paid time off
• Generous parental leave
• Regular team activities (virtual and in-person)
• The base pay for this position is $155,000 to $175,000. The pay range reflects the minimum and maximum target. Pay is based on several factors including location and may vary depending on job-related knowledge, skills, and experience. Certain roles are eligible for additional compensation such as incentive pay and stock options.

If you are based in California, we encourage you to read this important information for California residents linked here.

Truveta is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contractors with diverse backgrounds enables Truveta to better meet our mission and serve patients and health communities around the world. We recognize that opportunities in technology historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We strongly encourage individuals with these identities to apply even if you don’t meet all of the requirements.

Please note that all applicants must be authorized to work in the United States for any employer as we are unable to sponsor work visas or permits (e.g. F-1 OPT, H1-B) at this time. We appreciate your interest in the position and encourage you to explore future opportunities with us.

ML Postdoc Researcher - Healthcare AI Innovation

Truveta is the world’s first health provider led data platform with a vision of Saving Lives with Data. Our mission is to enable researchers to find cures faster, empower every clinician to be an expert, and help families make the most informed decisions about their care. Achieving Truveta’ s ambitious vision requires an incredible team of talented and inspired people with a special combination of health, software and big data experience who share our company values.

Our headquarters are in the greater Seattle area, but we celebrate and embrace a remote culture.  Participation in the Postdoctoral Research program requires that you are physically present in the United States for the duration of the program. #LI-remote

About Truveta 

Truveta is transforming healthcare by enabling researchers, clinicians, and life sciences organizations to learn from one of the most comprehensive collections of de-identified patient data in the United States. With access to longitudinal electronic health record (EHR) data from over 120 million patients (which represents over a third of the US population), we are uniquely positioned to drive breakthroughs in clinical research and improve patient outcomes. 

This Opportunity

We are seeking a highly motivated Postdoctoral Researcher to explore and develop novel applications of cutting-edge AI/ML technologies on large-scale real-world clinical data. 

This role is designed for recent PhD graduates who are passionate about pushing the boundaries of machine learning in healthcare. You will work at the intersection of machine learning, clinical data, and biomedical science, identifying new opportunities where modern AI can unlock insights that were previously out of reach. 

A key expectation is not just execution—but imagination: the ability to envision and prototype entirely new ways to use rich patient data to solve meaningful healthcare problems. 

Who You Are

• Curious and imaginative: You naturally think beyond existing solutions and ask “what hasn’t been done yet?”
• Impact-driven: You care about applying research to real-world healthcare problems
• Comfortable with ambiguity: You thrive in open-ended environments where defining the problem is part of the job
• Collaborative: You enjoy working across domains and learning from experts in different fields 

What You'll Do

• Innovate: Identify and propose novel, high-impact applications of AI/ML using large-scale EHR data
• Research & Prototype: Design, develop, and evaluate state-of-the-art models (e.g., foundation models, multimodal learning, causal ML, generative AI)
• Work Across Modalities: Integrate structured and unstructured EHR data with emerging data types such as genomics, imaging, and clinical notes
• Collaborate Cross-Functionally: Partner with clinicians, data scientists, and product teams to translate research ideas into real-world solutions
• Publish & Share: Contribute to top-tier conferences/journals and represent Truveta in the research community
• Explore the Unknown: Proactively identify problems that have not yet been addressed and define new research directions 

What We're Looking For

Basic Qualifications

• • Collaborate with researchers and engineers to design, develop, and refine large language models and generative models for various applications.
  • Utilize your expertise in machine learning and natural language processing to develop novel algorithms and methodologies for generative modeling tasks.
  • Implement, train, and fine-tune LLM and GPT-like models on large-scale datasets to ensure optimal performance and accuracy.
  • Stay up to date with the latest research advancements and techniques in the field of language modeling, generative modeling, and machine learning.
  • Deliver the next generation of innovation in trustworthy healthcare.

Preferred Qualifications

• • Experience with healthcare data (EHRs, claims, clinical notes) or biomedical data (genomics, imaging)
  • Familiarity with cutting-edge areas such as: 
  • Foundation models / LLMs in healthcare
  • Multimodal learning
  • Causal inference
  • Representation learning on longitudinal data
  • Track record of publications in top-tier ML or healthcare venues (e.g., NeurIPS, ICML, ICLR, MLHC, AMIA)
  • Ability to work across disciplines and communicate with both technical and clinical stakeholders 

Why Truveta? 

Be a part of building something special. Now is the perfect time to join Truveta. We have strong, established leadership with decades of success. We are well-funded. We are building a culture that prioritizes people and their passions across personal, professional and everything in between. Join us as we build an amazing company together. 

We offer: 

• Competitive compensation
• Company-issued laptop and equipment
• Opportunities for future full-time positions
• The range for this position is $50-$60 per hour

Truveta is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contractors with diverse backgrounds enables Truveta to better meet our mission and serve patients and health communities around the world. We recognize that opportunities in technology historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We strongly encourage individuals with these identities to apply even if you don’t meet all of the requirements.

Senior ML Engineer - Healthcare AI Innovation

Truveta is the world’s first health provider led data platform with a vision of Saving Lives with Data. Our mission is to enable researchers to find cures faster, empower every clinician to be an expert, and help families make the most informed decisions about their care. Achieving Truveta’ s ambitious vision requires an incredible team of talented and inspired people with a special combination of health, software and big data experience who share our company values.

This position is based out of our headquarters in the Greater Seattle area.  #LI-hybrid

What You'll Do

• Build & Innovate: Design and implement advanced ML models and systems using large-scale EHR data
• Explore New Frontiers: Identify and develop novel use cases for AI in healthcare that have not yet been widely explored
• Work Across Modalities: Leverage structured and unstructured clinical data, and integrate emerging data types such as genomics, imaging, and clinical notes
• Translate Research into Practice: Prototype new ideas and evolve them into production-ready solutions
• Collaborate Broadly: Partner with clinicians, researchers, product teams, and external stakeholders (e.g., pharma, life sciences organizations)
• Deliver Impact: Build solutions that enable better decision-making for customers and ultimately improve patient outcomes 

What We're Looking For

Basic Qualifications

• • Bachelor’s or Master’s degree (or PhD) in Computer Science, Machine Learning, or a related field
  • Strong foundation in machine learning, deep learning, or applied statistics
  • Experience building and deploying ML models in real-world settings
  • Proficiency in Python and modern ML frameworks (e.g., PyTorch, TensorFlow) 

Preferred Qualifications

• • Experience working with healthcare or biomedical data (EHRs, clinical notes, genomics, imaging)
  • Familiarity with modern ML approaches such as:
  • Large language models / foundation models
  • Multimodal learning 
  • Causal inference
  • Time-series and longitudinal modeling
  • Experience bridging research and engineering (e.g., taking ideas from papers to production)
  • Publications or demonstrated innovation in applied ML (a plus, not required) 

Why Truveta?

Be a part of building something special. Now is the perfect time to join Truveta. We have strong, established leadership with decades of success. We are well-funded. We are building a culture that prioritizes people and their passions across personal, professional, and everything in between. Join us as we build an amazing company together.

We Offer:

• Interesting and meaningful work for every career stage
• Great benefits package
• Comprehensive benefits with strong medical, dental and vision insurance plans
• 401K plan
• Professional development & training opportunities for continuous learning
• Work/life autonomy via flexible work hours and flexible paid time off
• Generous parental leave
• Regular team activities (virtual and in-person)
• The base pay for this position is $175,000 to $200,000. The pay range reflects the minimum and maximum target. Pay is based on several factors including location and may vary depending on job-related knowledge, skills, and experience. Certain roles are eligible for additional compensation such as incentive pay and stock options.

If you are based in California, we encourage you to read this important information for California residents linked here.

Truveta is committed to creating a diverse, inclusive, and empowering workplace. We believe that having employees, interns, and contractors with diverse backgrounds enables Truveta to better meet our mission and serve patients and health communities around the world. We recognize that opportunities in technology historically excluded and continue to disproportionately exclude Black and Indigenous people, people of color, people from working class backgrounds, people with disabilities, and LGBTQIA+ people. We strongly encourage individuals with these identities to apply even if you don’t meet all of the requirements.

Please note that all applicants must be authorized to work in the United States for any employer as we are unable to sponsor work visas or permits (e.g. F-1 OPT, H1-B) at this time. We appreciate your interest in the position and encourage you to explore future opportunities with us.

Role Overview 

We are seeking highly skilled, and motivated Director of Combination Product & Device Development, to lead the development, manufacturing, assembly and commercialization of high‑concentration biologic delivery systems, including, prefilled syringes, autoinjectors and other drug–device combination products.

The ideal candidate brings deep expertise in device design control, verification and validation, risk management, combination product regulations, and human factors engineering. This role requires hands‑on technical leadership and extensive experience with regulated devices and combination products (21 CFR 820, ISO 13485), as well as strong knowledge of global device standards (ISO, IEC 62366, ANSI/AAMI HE75) and FDA guidance. A successful track record supporting major regulatory submissions (BLA, MAA, IND/IMPD) and notified body assessments is essential.

Key Responsibilities 

Device Development

• Lead end‑to‑end development and commercialization of prefilled syringes, dual‑chamber cartridges, autoinjectors, and related combination product systems.
• Serve as a hands‑on technical leader and device SME across concept, feasibility, development, qualification, and launch phases.
• Define user needs and product requirements; lead prototyping, test method development, and design verification and validation (DV/V) activities.
• Drive design control documentation, risk assessments, usability studies, and human factors integration.
• Collaborate deeply with internal partners across CMC, drug product development, quality assurance, regulatory affairs, clinical development, supply chain, and commercial functions.
• Build and manage external relationships with CDMOs, device manufacturers, design firms, and suppliers to support development and lifecycle needs.
• Support lifecycle management of commercial combination products, including design history file (DHF) maintenance, change control, validation activities, complaint investigations, and post‑market surveillance.
• Evaluate technical decisions for cross‑functional impact and implement contingency plans as needed.
• Proactively identify and address manufacturing issues; coordinate technical solutions across internal and external teams.
• Lead creation of design control deliverables to ensure compliance with global device and combination product regulations.
• Oversee development of statistically sound verification protocols, reports, and design validation strategies.
• Lead or contribute to investigations of deviations, failures, complaints, and device‑related quality issues.

Design Controls & Human Factors

• Serve as the organizational expert in Human Factors Engineering, ensuring compliance with IEC 62366, ANSI/AAMI HE75, FDA guidance, and related industry standards.
• Integrate usability, human performance considerations, and safety risk mitigations into system requirements and development strategies.
• Ensure all human factors processes, deliverables, and standards are appropriately documented within the Design Control Quality System.
• Lead the cross‑functional design control sub‑team and drive cohesive integration across device design, analytical testing, packaging, manufacturing, clinical, supply chain, commercial, and regulatory functions.
• Manage and prioritize multiple concurrent projects, ensuring alignment to scope, timelines, budgets, and quality standards.

Regulatory Support

• Ensure compliance with global combination product and medical device regulations, including FDA and EU frameworks (e.g., EDDO, MDR).
• Author device‑related sections for regulatory submissions (BLA, MAA, IND/IMPD) and support notified body interactions.
• Represent the combination product function during regulatory audits and inspections.
• Lead proactive risk identification, mitigation planning, and escalation of critical issues.
• Demonstrate strong understanding of FDA’s Office of Combination Products (OCP), including primary mode of action (PMOA) requirements and combination product complaint expectations.

Qualifications 

• Master’s degree (or equivalent) in Mechanical Engineering, Biomedical Engineering, Chemical Engineering, or a related field.
• 15+ years of experience in biologic delivery device development with a proven record of supporting late‑stage development and commercial product launches.

• Experience with design controls, device risk management, medical devices, prefilled syringes, autoinjectors, and related scientific and technical concepts and techniques is required for this position.
• Deep knowledge of subcutaneous delivery systems, systems engineering principles, device materials, and manufacturing technologies; experience with biologics and packaging development preferred.
• Strong understanding of FDA and EU regulations for medical devices and combination products, including relevant quality systems and standards.
• Experience managing external partners, vendors, and contract manufacturers.
• Proven experience with cGMP process development, manufacturing controls, and process risk assessments.
• Excellent communication, leadership, and cross‑functional collaboration skills.
• Ability to thrive in a fast‑paced, agile environment; start‑up experience is highly desirable.

Position Location 

This is a fully remote role with up to 15-20% domestic and/or international travel.

The anticipated salary range for candidates for this role is $210,000 - $235,000. The final salary offered will depend on several factors, which may include, but not limited to, relevant years of experience, educational background, and geography.