Legend Biotech is seeking an Principal Scientist, Vector Biology as part of the Vector Biology Upstream team based in Philadelphia, PA.

Role Overview

Legend Biotech seeks a highly experienced and scientifically driven Principal Scientist to join the Vector Biology Upstream team in Philadelphia, with a strategic focus on early process development and the establishment of a manufacturable lentiviral vector (LVV) platform in support of in-vivo CAR-T programs. This senior individual contributor role will serve as a scientific cornerstone within R&D, leading the early-stage definition, interrogation, and optimization of upstream LVV processes from molecular construct design through scalable bioreactor manufacturing with the deliberate intent of building a robust, developable process foundation that can be advanced into late-stage development and commercialization. The Principal Scientist will bring a rare combination of molecular biology depth and bioprocess engineering breadth, functioning as a key technical authority who bridges construct-level design decisions with upstream process outcomes, while closely interfacing with Downstream, Analytical, and Technical Development partners to ensure end-to-end process coherence and readiness for technology transfer.

Key Responsibilities

• Establish and optimize early-stage seed train strategies from shake flask through bench-scale bioreactor, defining the foundational process parameters, cell culture conditions, and operational ranges that will underpin a scalable and manufacturable LVV platform.
• Apply molecular biology expertise to evaluate LVV constructs encompassing plasmid architecture, packaging system selection, promoter and transgene configuration, and transfer vector optimization to establish high-performing, platform-compatible vectors that meet manufacturability and potency requirements for in-vivo CAR-T applications.
• Design and optimize LVV production workflows, including transient transfection systems and emerging stable producer cell line platforms, to systematically improve vector yield, product quality attributes, and process robustness as part of an integrated early process development strategy.
• Conduct systematic media optimization, feeding strategy evaluation, and bioreactor process control development to define process setpoints, identify critical process parameters (CPPs), and establish the mechanistic understanding needed to support scale-up to 40-L and beyond.
• Partner closely with Downstream colleagues to understand purification process constraints and integrate upstream design decisions including harvest conditions, clarification approaches, and vector quality attributes that enable a cohesive, end-to-end manufacturable process. 
• Design and execute fit-for-purpose early process development studies to generate the foundational data packages required for process lock, comparability assessments, and downstream regulatory filings; apply structured Design of Experiments (DoE) and risk-based approaches to maximize information yield.
• Serve as the upstream scientific lead within Vector Biology, providing authoritative technical input to cross-functional forums on construct-process relationships, early development strategy, and the stage-appropriate advancement of research findings into formal process development programs aligned with IND-enabling timelines.
• Exercise a high degree of scientific independence in designing and executing complex experiments; proactively identify technical risks, generate mechanistic hypotheses, and implement data-driven solutions with minimal oversight to keep early development programs on track.
• Synthesize complex experimental datasets into clear, structured data packages and deliver evidence-based technical recommendations that drive go/no-go decisions, inform process development strategy, and support program progression within Vector Biology and across R&D functional teams.
• Author high-caliber technical reports, early process development summaries, and stage-gate presentations that communicate scientific progress, key process decisions, and development risk assessments to Vector Biology leadership and cross-functional R&D stakeholders.
• Operate in full adherence to BSL-2 biosafety requirements and Legend Biotech’s research policies; maintain rigorous, contemporaneous electronic laboratory notebook records that meet scientific reproducibility standards and support future transition into GxP-aligned development stages.
• Champion experimental reproducibility and data integrity through rigorous, organized documentation practices that meet the highest standards of scientific rigor and regulatory traceability.
• Apply molecular biology expertise to design, engineer, and evaluate LVV constructs encompassing plasmid architecture, packaging system selection, promoter and transgene configuration, and transfer vector optimization to establish high-performing, platform-compatible vectors that meet manufacturability and potency requirements for in-vivo CAR-T applications.

Requirements

• MS degree with 10+ years; or PhD degree with ~5-8+ years of progressive industry experience in Bioengineering, Cell Biology and Chemical Engineering, or a closely related discipline. Advanced degree (PhD) with a molecular biology or virology foundation is preferred for this Principal Scientist role in early process development.
• Demonstrated hands-on expertise in viral vector production, upstream process development, and characterization across multiple development scales, with a clear track record of translating early research-stage processes toward manufacturable, scalable platforms (required).
• Substantial experience in mammalian suspension cell culture and upstream bioprocessing, with meaningful exposure to molecular biology workflows relevant to viral vector construct engineering.
• Experience with bioreactor operations (up to 50 L preferred) and familiarity with downstream processing operations including clarification, chromatographic purification, and tangential flow filtration with the ability to apply downstream process constraints to upstream design decisions is a strong differentiator. 
• Meaningful early process development experience within gene therapy or viral vector platforms, with direct hands-on contribution to defining manufacturable upstream processes from concept through bioreactor scale.
• Exceptional analytical acumen and structured scientific reasoning; experienced in the application of Design of Experiments (DoE), multivariate data analysis, and risk-based decision frameworks to accelerate early process development and maximize learning efficiency.
• Demonstrated commitment to scientific rigor and research data integrity, with proficiency in maintaining meticulous, contemporaneous electronic laboratory notebook records that ensure experimental reproducibility and are structured to support future GxP-aligned technology transfer activities.
• Highly organized and execution-oriented, with demonstrated capacity to manage multiple concurrent early development workstreams, prioritize effectively in a fast-paced R&D environment, and deliver scientifically sound results within program-driven timelines.
• Exemplary oral and written communication skills, with the ability to translate complex early process development findings into compelling scientific narratives for diverse audiences including R&D leadership, CMC colleagues, and cross-functional program teams while operating with equal effectiveness as a self-directed scientific contributor and an engaged collaborative partner
• Proficiency in molecular biology techniques central to viral vector construct design, including plasmid architecture and engineering, packaging system configuration, promoter selection and regulatory element optimization, transgene design, and transfer vector development to support LVV platform optimization (preferred).
• Working knowledge of downstream processing operations —encompassing harvest and clarification strategies, affinity and ion-exchange chromatography, and tangential flow filtration — with the scientific acuity to incorporate purification process requirements and vector quality attribute targets into upstream process design; experience in integrated upstream-downstream process development is preferred.

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Position Overview

Woolpert is hiring a hiring a Traffic Engineer to join our dynamic Transportation team at any of our Pennsylvania offices. This position reports to the National Traffic Team Lead and is responsible for completing traffic signal design plans and Americans with Disabilities Act (ADA) services, in addition to, but not limited to signing and pavement marking plans, traffic control design, traffic impact studies, crash analysis, traffic calming designs, HOP reviews, etc.

Candidate is preferred to sit in one of our Pennsylvania offices (Harrisburg, Sharpsburg or King of Prussia). This is still a hybrid role and time in the office is negotiable. 

We are unable to provide visa sponsorship for this position.  Applicants must already possess work authorization in the country the job is located.

Qualified candidates may be eligible for a signing bonus of up to $5,000, based on experience and role alignment. Bonus eligibility is contingent upon 12 months of service and must be repaid if the employee leaves the company within one year of hire.

What You Will Do:

• Performs engineering computations, conducts evaluations, design analyses, and design development.
• Prepares reports, recommendations and opinions for approval.
• Aid in design or oversee staff in the design of projects.
• Applies standard engineering practices and techniques to adjust and correlate data; recognizes and resolves discrepancies in results and follows operations through a series of related steps or processes.
• Works as a member of project team in the development of data and/or applications.
• Willing and able to sign and seal plans in the State of Pennsylvania or the ability to file for reciprocity.
• Ability and willingness to work across geographies. This is in terms of work type, not necessarily required to travel.
• Able to help train and mentor less experienced staff.

What You Will Bring:

• Must have 4 years related experience.
• Bachelor’s degree in civil engineering required.
• Experience in the field of Traffic Engineering is required.
• PE License or the ability to obtain one is required.
• Experience in Civil 3D or Bentley/Microsoft products is required.
• Must be able to read, analyze and interpret basic scientific, technical, financial and legal documents.
• Must be able to apply mathematical operations to such tasks as frequency distribution, determination of test reliability and validity, analysis of variance, correlation techniques, sampling theory and factor analysis.
• Must have average verbal and written communication skills for both internal and external relationships.
• Must be able to respond effectively to sensitive inquiries from clients, regulatory agencies, and/or members of the business community.
• Must have Microsoft Office suite skills.
• Must be familiar with discipline related software applications.

Benefits You Will Love

Certified as a Great Place to Work, Woolpert is one of the fastest-growing architecture, engineering, and geospatial companies in the world. With over 75 offices and countless projects around the globe, you’ll work on meaningful assignments that improve quality of life around the world. In addition to offering competitive pay, we provide employees with a robust set of unique benefits, including:

• Freedom to Work program: Set your own schedule and location (as appropriate).
• Principal program: Earn the opportunity to become an owner of the firm.
• Flexible paid time off/vacation: Take time off when it makes sense for you and your team.
• Career development: Explore a wide range of learning and growth opportunities within and across industries.
• Health, life, vision, and dental insurance: Cover all your medical bases.
• Paid sick time, retirement plan, fitness reimbursement, pet insurance, identity protection, technology stipend, employee assistance program, and more!

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Location: Remote (U.S. or Canada)

Type: US Applicants – Full-Time; Canadian Applicants – Independent Contractor

About Human Agency

We're scaling rapidly and have a growing pipeline of opportunities that demand exceptional talent across disciplines. Our mission is to bring on individuals, from creative producers to technical experts to entrepreneurial leaders, who can help us realize this next chapter of growth.

We are a company of doers. Leaders roll up their sleeves, teams work flat, and everyone contributes to what ships. Titles don't insulate us from feedback or basics. We invite critique, learn quickly, and keep raising the bar. The best ideas win here, no matter where they come from, because clients trust us to deliver the strongest outcomes every time.

Our clients' missions, products, and bottom lines are sacred. We immerse ourselves in their world, becoming stewards of their goals and partners in solving big problems. Every product, strategy, or asset we create must be both beautiful and functional; practical, usable, and designed for real-world impact.

Humans are our most valuable resource, and we only grow by hiring people who push us forward. Across strategy, engineering, design, data, and operations, we seek out teammates who raise the bar and make us better. Always hire up, never down.

We partner with organizations of all sizes to explore, design, and implement AI strategies that are secure, scalable, and human-centered. We believe AI should amplify human potential, not replace it, and we build with that conviction in every engagement. From advisory and tooling to implementation and education, we meet clients where they are and help them integrate AI in ways that align with their mission and values. Our goal is to empower teams to work smarter, move faster, and unlock new possibilities through thoughtful, responsible innovation.

And through it all, we lead with purpose, love, and adventure. We do meaningful work with people we care about, and we make the ride an adventure worth taking. Because at Human Agency, who we are and how we work are one and the same.

The Opportunity

Human Agency is an AI-native consultancy that builds, ships, and operates alongside our clients. We don’t advise from the sideline — we embed inside enterprise organizations and deploy production AI systems that do real work.

Our current anchor engagement is inside one of the largest privately held construction enterprises in the United States — LLM orchestration, document intelligence, workflow automation, enterprise integration. Not strategy decks. Not innovation labs. Systems that run.

We need a Managing Director of Technology to own the technical side of the house as we scale Human Agency. That means leading client delivery, making architecture calls, building the engineering team, and being the technical voice in rooms with C-suite executives. You’ll work closely on strategy with both the Founder and the Managing Director of AI — but the technical execution, the team, and the platform are yours.

This role requires someone who can move between writing production code and presenting to a client’s CEO in the same week. If that sounds like whiplash, this isn’t the right fit. If that sounds like Tuesday, keep reading.

What You’ll Do

Lead technical delivery for enterprise clients. You’re the most senior technical person in the room on our biggest engagements. You decide what’s feasible, design the architecture, and make sure it ships. When a client executive asks “can we do this?” — you’re the one who answers.

Build how we deliver, not just what we deliver. One client engagement works because of talented people and brute effort. Ten engagements work because of systems. You design the repeatable model — how we scope, staff, build, and deploy — so the team can run engagements without you in every meeting. That means building discovery frameworks, reference architectures, deployment templates, and evaluation routines that actually get used.

Hire and develop the engineering team. You set the bar, own the pipeline, and make the calls on who joins. We need people who can build with high autonomy in ambiguous environments, and you know how to find them. You also know how to make good engineers better through architecture guidance, code review, and honest feedback.

Own platform and infrastructure decisions. Build vs. buy, tooling, deployment, security — you make the calls. A Principal Engineer handles day-to-day infrastructure execution; you set priorities and architectural direction.

Shape our AI strategy through the lens of what actually ships. You have real opinions on LLM orchestration, RAG, agents, evaluation, and fine-tuning — formed by building things, not reading about them. You decide which technical bets we make and which we skip, based on what creates value for clients, not what looks good on a slide.

What We’re Looking For

• You’ve built and shipped AI/ML systems in production. Not prototypes. Not demos. Things that run and that people depend on.
• You’ve hired and led a technical team — at least 5 people, ideally more. You’ve seen what breaks when a team grows and you’ve fixed it.
• You can explain a technical trade-off to a non-technical executive in a way that helps them make a decision. You’ve done this in high-stakes settings.
• You have strong opinions on AI architecture grounded in hands-on experience — and you change those opinions when the evidence says to.
• You’re comfortable in the weeds. When something is broken or a team is stuck, you get in and help, not schedule a meeting about it.
• You know your way around cloud infrastructure and engineering practices well enough to make platform calls with confidence.

Bonus points for: you’ve scaled a startup or early-stage company before — built the team, built the systems, lived through the growing pains; experience in a services or consultancy model (SOWs, staffing, client delivery); a network of engineers you’ve worked with and would hire again.

You Should Apply If

• You’d rather build AI systems than talk about AI strategy
• You want to own a technical organization, not manage a lane inside someone else’s
• You’re comfortable making big decisions with imperfect information — and owning the outcome
• You want to work somewhere with real revenue, real clients, and real problems to solve
• You’re energized by building a company — not just writing code, but shaping how the whole thing works

You Should Not Apply If

• You want a CTO-like title with a strategy focus and minimal hands-on building
• You’re uncomfortable getting into production-level detail when the situation calls for it
• You expect an established engineering org with playbooks, processes, and a support structure already in place
• You’d rather delegate technical depth than engage directly
• Your experience is solely in product companies and you’re not interested in building for clients

Considerations

Education: Bachelor’s degree or equivalent experience; advanced degrees are a plus but not required

Ethics: Commitment to responsible AI practices — transparency, human oversight, privacy

Travel: Periodic (10–20%) for client work, team offsites, and events

Location: Remote-friendly; U.S. or Canada, with preference for EST timezone alignment

Why Join Human Agency

We’re profitable, growing, and building AI systems that run in production for billion-dollar companies. The team is small, the clients are real, and the work matters.

The work is real and the opportunity is massive. We’re building a company — the systems, the team, the delivery model, the culture — and we need someone to own the technical side of that build.

If you’re the kind of person who’d rather build the engine than describe the engine, we want to talk.

Equal Opportunity Commitment

Human Agency is an Equal Opportunity Employer. We value diverse perspectives and are committed to building inclusive, high-performing teams where everyone can do their best work.