Legend Biotech is seeking a Principal Scientist, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)—including clarification, chromatography, TFF, sterile filtration and fill/finish—ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

• Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
• Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
• Provide hands-on training as needed.
• Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs
• Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
• Communicate the potential for issues and delays along with solutions and mitigation approaches.
• In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
• Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
• Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
• Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
• Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
• Tech transfer process to/from other Legend sites or CDMOs
• Resolve conflict and proactively identify/address performance issues.
• Ensure compliance with regulatory requirements. 

Requirements

• Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Virology, Molecular Biology, or a related field.
• 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
• Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred)
• Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
• Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field
• Ability to implement closed-system processes and maximize cost effectiveness
• Strong knowledge in engineering modeling and optimization.
• Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
• Creative, strategic thinking
• Strong troubleshooting skills
• Preferred experience in developing vector processes tailored for CAR-T generation and systemic delivery
• Preferred experience in handling large scale(>50L) purification process.
• Language: English. Mandarin is a plus. 

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Legend Biotech is seeking a Preclinical Scientist as part of the Research and Early Development team based in Somerset, NJ.

Role Overview

This position will perform preclinical IND-enabling pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology to assist preclinical cell therapy studies from discovery to first-in-human trials, and through marketing authorization. Furthermore, the successful candidate will work in a collaborative environment , and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities

• Develop and validate assays to support diverse projects from lead optimization to the conduct of preclinical pharmacology and toxicology studies for regulatory submission. This includes, designing, optimizing, and implementing IND-enabling studies, contributing to the creation, review, and approval of prospective standard operating procedures, executing in vitro and in vivo IND-enabling studies, recording all experiments in an electronic laboratory notebook, reporting any deviations, analyzing and reporting processed data in the form of a study report.
• Design and support in vitro IND-enabling studies to assess efficacy and safety of cell therapies. 
• Support the preparation of scientific and regulatory documents of IND-enabling preclinical studies.
• The Preclinical Scientist will work independently reporting directly to the Director of Preclinical Pharmacology and Toxicology.
• The Preclinical Scientist will demonstrate competency and professionalism especially as it pertains to using the scientific method to design, execute, and troubleshoot in vitro laboratory experiments.

Requirements

• BS plus 5 years of experience, MS plus 3 years of experience.
• Work experience in immunology, cancer biology or related fields.
  
• Knowledge and expertise in immune-oncology of large molecules or cell therapy is a plus.
  
• Strong scientific background with hands on experience in cellular and molecular biology techniques (e.g., flow cytometry, ELISA, cell culture and cytotoxicity assays, qPCR, Western Blot and others).
  
• Demonstrated track record of scientific contributions in peer-reviewed journals and symposia.
  
• Ability to manage multiple programs in parallel while delivering on key milestones.
  
• Knowledge of GLP and regulatory agencies is a plus.
  
• Ability to multi-task in a fast-paced, highly collaborative diverse team environment.

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Legend Biotech is seeking a Principal Scientist, Clinical Biomarker, Immunology, Immuno-Oncology, & Hematology (Contractor) as part of the Research & Development team based in Somerset, NJ.

Role Overview

We are seeking a highly motivated and innovative Principal Scientist to join our immunology and immuno-oncology (IO) clinical biomarker projects, with a dedicated focus on hematological malignancies. In this role, you will drive the clinical translational understanding of novel therapy in hematology. You will serve as the biology lead on cross-functional project teams, drive MOA of novel cell therapy and clinical biomarker strategy.

Contract Duration: 12 months

Key Responsibilities

• Scientific Leadership: Design, execute, and analysis results from clinical studies to investigate the mechanisms of action for novel IO targets in hematological indications (e.g., AML, DLBCL, Multiple Myeloma).
• Translational Strategy: Bridge discovery and clinical development by utilizing primary human samples and clinical datasets to validate targets and understand the immune microenvironment in hematology.
• Understanding MOA: Oversee the generation and interpretation of high-dimensional molecular and cellular data. Leverage advanced single-cell technologies (e.g., scRNA-seq) to deeply profile immune cell compartments, particularly T-cell states and exhaustion markers, to inform patient stratification and biomarker hypotheses.
• Cross-Functional Collaboration: Partner closely with other functional teams for better understanding of MOA and fundamental immunology

Requirements

• Ph.D. in Immunology, Immuno-Oncology, Cellular Biology, or a closely related discipline, can initiate and lead data driven MOA studies. Experience with cell therapy a plus but not required.
• A minimum of 5-8+ years of post-doctoral and/or industry experience in biotech or pharma, with a proven track record of advancing IO programs. Deep understanding of immunology, particularly T cell biology highly desirable.
• Deep biological understanding of hematological malignancies and the unique tumor immune microenvironment of the blood and bone marrow.
• Experience working with multiple dimensional data, extract biological insights from data highly desirable.
• Exceptional written and verbal communication skills, with the ability to distill complex data into clear, actionable strategic decisions.

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#Li-Contract

Legend Biotech is seeking a Sr. Principal/Principal Scientist as part of the Research & Early Development team based in Somerset, NJ.

Role Overview

Legend Biotech is seeking a highly experienced Senior Principal Scientist / Principal Scientist – Flow Cytometry to provide scientific leadership and hands-on expertise in flow cytometry to support cell and gene therapy programs from IND-enabling studies through early- and late-stage clinical development. This role is critical for ensuring scientific rigor, data quality, and strategic insight across in-house and outsourced flow cytometry activities, including assay development, validation, CRO oversight, and deep data interpretation to support translational, PK/PD, and regulatory decision-making.

Key Responsibilities

Scientific & Technical Leadership

• Lead the design, development, optimization, qualification, and validation of multicolor and spectral flow cytometry assays supporting IND-enabling animal studies and clinical trials.
• Provide subject-matter expertise in panel design, antibody and reagent qualification, gating strategies, and data analysis for complex immunophenotyping applications.
• Conduct deep scientific review and interpretation of flow cytometry datasets to support PK/PD, mechanism-of-action, and translational insights.

CRO & Vendor Oversight

• Serve as the primary scientific lead for external laboratories and CROs performing flow cytometry assays.
• Oversee assay transfer, validation, execution, troubleshooting, and data delivery at CROs.
• Ensure outsourced activities meet Legend quality standards, regulatory expectations, and program timelines.
• Identify risks related to assay performance, data quality, and operational execution, and implement mitigation strategies.

Regulatory & Compliance

• Author, review, and approve bioanalytical assay validation reports, study reports, and regulatory documentation.
• Ensure flow cytometry assays and data packages are inspection-ready and compliant with GxP principles and data integrity requirements.
• Contribute to bioanalytical sections of IND and other regulatory submissions.

Cross-Functional Collaboration

• Partner with Clinical, Translational Research, Biomarkers, Nonclinical Safety, and Data Science teams to align assay strategy with program objectives.
• Provide scientific input to study design, endpoint selection, and interpretation of bioanalytical results.
• Communicate complex data clearly to multidisciplinary stakeholders.

Operational Excellence & Mentorship

• Establish and maintain SOPs, best practices, and governance for in-house flow cytometry workflows.
• Mentor and scientifically guide junior scientists and associates.
• Evaluate and implement new technologies, platforms, and analytical approaches to enhance capabilities.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or related discipline with 8+ years (Principal Scientist) or 10+ years (Senior Principal Scientist) of relevant industry experience; or M.S. with 12+ years of experience.
• Extensive hands-on experience with multicolor and spectral flow cytometry platforms.
• Demonstrated experience supporting cell therapy and/or gene therapy programs.
• Strong understanding of bioanalytical method development, validation, and regulatory expectations.
• Proven ability to lead complex programs, influence cross-functional teams, and provide strategic scientific direction.
• Experience overseeing CROs and external vendors.
• Excellent written and verbal communication skills.
• Experience with CAR-T, in vivo gene delivery, or other advanced cell therapy platforms.
• Experience contributing to IND-enabling or regulatory filings.
• Background in translational PK/PD applications of flow cytometry. 

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#Li-Onsite

Legend Biotech is seeking a Senior Clinical Research Scientist as part of the Clinical Development team based in Somerset, NJ.

Role Overview

The Clinical Research Scientist (CS) in Clinical Development is an important role in the company supporting the development and life cycle of drug development projects. The Clinical Research Scientist will work closely with the Clinical Trial Lead/Medical Lead and Clinical Trial Manager to design and implement clinical trial protocols and manage sites, CROs and other associated work. In addition, the CS will support their manager to ensure program consistency & alignment across studies, working closely with cross-functional teams for achieving project goals, within timelines & with high quality. This clinical scientist will support early phase drug development in autoimmune indications.

Key Responsibilities

• Responsible to ensure the data review and cleaning activities meet the quality standards to support database locks in collaboration with data management and medical lead/clinical trial lead. Uses clinical and disease state knowledge to make recommendations for methods and strategy for data cleaning approach
• Collaborate with other functions to successfully support the planning and execution of clinical studies. Provides independent leadership of all areas requiring clinical input with oversight from the assigned Clinical Trial Lead/Medical Lead, and provides innovative and quality solutions for assigned problems and tasks.
• Provides clinical input and strategic recommendations for the planning and implementation of assigned clinical trial(s) including investigator selection, patient recruitment, feasibility questionnaire, training PowerPoints, and supporting Ethics committee submissions.
• Contributes to the strategic planning, preparation, and review of clinical documents (Protocol, ICFs, CSR, investigator brochure). May lead certain documents or sections of documents, including incorporation of input from other cross-functional team members.
• Provides clinical input and strategic recommendations for regulatory documents needed for all stages of assigned trial lifecycle (IND documentation, HA briefing books, BLAs, and Orphan Drug Applications).
• Responsible for clinical portions of key data management/statistical documents (eg: Case Report Forms, edit checks, data review plan and reports).
• Contribute to the planning and execution of external meetings and internal stakeholder meetings (e.g., Ad Boards, IMs, Governance, DMCs, Regulatory Authority, Dose Escalation meeting); responds to or triages questions for appropriate escalations. May have a speaking role on meetings when appropriate.
• Supports their manager when asked to contribute to harmonization between clinical trials and process improvement initiatives.
• May have the authority to make decisions related to issuing data cleaning queries and can decide whether there is a need to escalate for further discussion with the medical lead. They may also be delegated tasks from the clinical trial lead/medical lead for which they have decision making authority e.g. comment resolution when leading document creation.

Requirements

• At least a Bachelor’s degree in life science discipline.
• Bachelor’s degree with 4+ years’; or MS with 3+ years’; or PharmD/PhD with 2+ years of pharma experience in clinical development or related function.
• CAR-T cell therapy and/or autoimmune disease experience is a plus.
• Good interpersonal & communication skills, including oral, written and interpersonal.
• Ability to effectively manage conflicts and negotiations while providing impact and influence.
• Collaborative with the ability to operate across multiple geographies.
• Good leadership & organizational skills, analytical skills, and presentation skills.
• Creative problem-solving skills.
• Strong organizational and project management skill and the ability to multitask.
• Computer literacy required (MS word, MS excel, MS PowerPoint and MS Project).
• Oncology Therapeutic Experience preferred.
• Excellent working knowledge of GCP, FDA and ICH Guidelines.

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COMPANY OVERVIEW

Lynx Analytics was founded in 2010 by a group of INSEAD students and professors with a strong research background in graph analytics. Several of our founders since then became professors and faculty directors of analytics centers at leading US universities. Our founding purpose? To apply graph theory to simplify and solve complex, real-world business problems.

Our mission has evolved over the years, and we currently offer a range of cutting edge data analytics and AI solutions to help companies transform their operations and optimise their commercial performance. Back then, graph theory was mostly the purview of social networking sites. We wanted to expand this technology and help companies leverage their communities to unlock greater growth.

Lynx has offices in Singapore, US, Hong Kong, Hungary, and operations in several other countries such as Canada, Germany, Indonesia. We work with some of the world’s largest companies and are constantly looking to expand our knowledge base and geographical footprint. Lynx Analytics’ technology is deployed with various Clients internationally and has significant growth potential.

We have a diverse and inclusive global team comprising Professors, PhDs, MSc’s, and MBAs from Ivy Leagues, INSEAD and NUS with a broad spectrum of experience in start-ups and blue-chip companies (Google, Databricks, ZS, Abbvie, Amgen, Vodafone, Morgan Stanley, Palantir, Katana Graph to name but a few). It is the combination of our industry insight and experience, scalable proprietary technology, and highly qualified people that drives our compelling value proposition.

We are looking for ambitious, innovative, empathetic and relentless team players to explore the career opportunities that we offer as we continue to scale our operations.

About the role:

We are looking for a Senior Data Scientist to work on and lead complex data analysis projects using standard modelling, data transformation approaches and Generative AI. 

They should be comfortable working with very large data sets residing in different data stores in disparate formats. The role requires the candidate to be strong with hands-on implementation and has the potential to move fast onto a high-growth career trajectory. Our future colleagues must have excellent communications skills as well as being able to visualize and present complex Data Science solutions for the main (C-level) stakeholders of the projects. Leadership experience and charisma are huge advantages.

Key responsibilities will include:

• Designing and Delivering Solutions for a defined Data Science Related Problem
• Present the results / Prepare Presentations for the Project Stakeholders
• Create reusable documentations, presentations and code libraries during the projects
• Participating in internal education and research tasks
• Leading smaller data science tasks with the help of internal leadership and PMO

To succeed in this role, you should fulfill the following requirements:

• More than 8 years of overall experience in data science field.
• Experience in the life sciences industry is preferred
• Mathematics, Statistics, Economics, Computer Science, Engineering or related degree (MSc or PhD is preferred)
• Understanding complex Data Science Solutions
• Solid knowledge of probability theory, statistics, data science algorithms and their application in Customer Retention, Campaign Management etc. areas
• Good Communication (both verbal and written) and Data Visualization Skills
• Coding abilities at least one of the following languages: Python (preferred), R, SAS, C, JAVA (or similar)
• Solid experience in LLM / NLP

Why You Will Love It Here: 

• Work on real-world AI and advanced analytics solutions with measurable business impact.
• Collaborate with a global team of engineers and data scientists.
• Exposure to diverse industries, modern cloud platforms, and cutting-edge AI technologies.
• A collaborative culture that values real outcomes
• High ownership, zero micromanagement
• Rapid learning opportunities and diverse challenges
• Flexible work hours, remote-friendly setup
• Flat organisational hierarchy with high visibility and accessibility to our leaders

Role: Principal Data Scientist - Commercial Analytics

Title: Senior Lead, Principal Data Scientist / Associate Director - Data Science

Location: NY / NJ (USA)

Summary:  The role is expected to serve as the primary client-facing data science lead for commercial analytics and RGM engagements. In this role, you will partner with senior client stakeholders, translate business challenges into data science solutions, review and guide offshore deliverables, and ensure delivery of high-quality outcomes. You will combine hands-on modeling expertise with client leadership, solution ownership, and team guidance to drive measurable business impact Provide clear guidelines for offshore development teams & own outcomes. You will nurture key client relationships to ensure client account success

Desired Experience : 

• 8–12 years of overall experience.
• 3+ years in consulting or client-facing analytics roles.
• 3+ years of experience in CPG or adjacent commercial analytics environments.
• Proven experience engaging with senior stakeholders and leading client conversations.
• Strong track record in data science, statistics, and machine learning

Role & Responsibilities :

• Develop and refine analytics & ML models and tools (e.g., Price Elasticity, iPPA diagnostics, Portfolio Simulators, TPO, TPM etc.) to support strategic RGM decisions
• Employ your analytical skills to decipher large datasets, and identify opportunities to enhance existing solutions, as well as develop new ones as scalable proof-of-concepts (PoC).
• Work closely with cross-functional teams, including data scientists, data engineers and product managers and business experts to ensure the smooth development of RGM models and translate outcomes to business stakeholders
• Collaborate extensively with business stakeholders to gather requirements, deeply understand challenges and identify opportunities.
• Leading client workshops where broad vision and ambiguous business problems are articulated to be solved through data analytics and AI
• Independently liaise with customers and convincingly present solutions in an unstructured and ever-changing client environment. Be able to independently question the customer, when required.
• Perform a role that involves a combination of hands-on contribution and customer engagement
• Contribute to organization building through training, mentoring, and developing repeatable analytic approaches

Primary Skills (Mandatory)

• Strong foundation in ML and statistical concepts.
• Proficiency in SQL, Python, and PySpark.
• Experience with Snowflake, BigQuery, Azure, AWS, or Databricks.
• Experience with CPG data and commercial analytics, including pricing, promotion, mix, e-commerce, or customer analytics.
• Ability to convert rigorous analysis into strategic recommendations.
• Strong project management, communication, and team leadership skills
• Strong problem-solving skills and a creative mindset for disrupting how RGM analytics is conducted today. Be at the forefront of innovations in commercial analytics space

 Secondary Skills (Good to have):

• Exposure to supply chain analytics, manufacturing analytics, or e-commerce analytics.
• Data engineering / MLOps experience.
• Dashboarding experience with Power BI or Tableau
• Exposure to Agentic AI / LLMs or any other Gen AI capabilities