Legend Biotech is seeking candidates for Legend's Finance Management Leadership Development Program as part of the Finance team based in Somerset, NJ.

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand. 

Key Responsibilities

• The Finance Management Hi-Po Leadership Development Program is a 2-3-year enterprise leadership accelerator designed for high-potential MBA graduates ready to influence financial strategy in a fast-growing, innovation-driven biotech organization. Through 3-4 strategic rotations (8-12 months each) which may include Finance & Accounting, Procurement, Corporate Finance, and Internal Audit, you will gain deep technical expertise and broad enterprise perspective.
• This structured program integrates high-impact business experiences, executive mentorship, and a Leadership Development Series focused on developing leaders at every level, from leading self and others to influencing senior stakeholders. and driving enterprise-wide business outcomes.
• At Legend Biotech, we believe our people are our greatest asset. This program reflects our unwavering commitment to professional development, career mobility, and long-term leadership growth; empowering early-career talent to take on meaningful challenges, expand their impact, and shape the future of our organization.

Requirements

• Recent MBA graduate (Class of 2023–2026), with concentration in Finance, Accounting, or related field preferred.
• 2-3 years of professional experience demonstrated progressive responsibility and analytical rigor.
• Strong financial modeling, problem-solving, and communication skills.
• Demonstrated leadership potential and aspiration to grow into Director-level and broader enterprise finance leadership roles.
• Demonstrated skills in developing and implementing enterprise technology automation, visualization and analytics solutions to improve productivity and performance. 

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Legend Biotech is seeking a HR Management, Leadership Development Program as part of the Human Resources team based in Somerset, NJ.

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions.

Key Responsibilities

• As an HR Management participant within this program, you will build the strategic, operational, and leadership capabilities required to drive talent outcomes in a fast-growing, mission-driven biotech organization. The experience is intentionally designed to strengthen succession readiness for critical leadership roles while equipping you with the cross-functional perspective and business acumen needed to lead at scale.
• At Legend Biotech, we believe our people are our greatest asset. This program reflects our unwavering commitment to professional development, career mobility, and long-term leadership growth; empowering early-career talent to take on meaningful challenges, expand their impact, and shape the future of our organization.
• Complete 3-4 cross-functional rotations over a 3-year structured leadership program (8-12 months per rotation) across Talent Acquisition, HR Operations, HR Business Partnering, Total Rewards, and/or Learning & Organizational Development.
• Lead and support high-impact HR initiatives aligned to talent strategy, organizational design and workforce planning.
• Partner with senior leaders to solve complex organizational challenges and drive scalable HR solutions aligned to enterprise growth.
• Participate in a Leadership Development Series focused on strategic thinking, executive presence, and enterprise leadership readiness.
• Deliver measurable business impact and progressively increase scope, influence and accountability across rotations.

Requirements

• Recent MBA or MA graduate (Class of 2023-2026) in Human Resources or related field.
• 2–3 years of professional experience (HR or related business experience preferred).
• Preferred experience in a Life Sciences organization or related business.
• Demonstrated leadership potential, strong analytical and communication skills, and a desire to grow into future leadership roles.

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Legend Biotech is seeking candidates for Legend's R&D Management Leadership Development Program as part of the R&D team based in Somerset, NJ / Philadelphia, PA.

Role Overview

The R&D Leadership Program at Legend Biotech is a highly selective, enterprise leadership accelerator designed for high-performing PhD scientists with 7–10 years of industry experience who are ready to transition from deep scientific expertise to enterprise-level leadership.

At Legend Biotech, we are advancing the frontiers of cell and gene therapy to deliver transformative cures for patients worldwide. We believe breakthrough science starts with bold thinkers, collaborative teams, and leaders who are ready to make an impact early in their careers.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

The R&D Management Hi-Po Leadership Development Program is a 2-3 year project-based enterprise leadership accelerator designed for high-potential experienced PhD graduates who aspire to shape the future of cell and gene therapy

As a participant, you will take on three enterprise-critical projects, each aligned to key business priorities and pipeline milestones. You will:

• Lead complex, cross-functional projects that directly impact R&D strategy, clinical advancement, or manufacturing scalability
• Partner with senior leaders across Research, Clinical, Regulatory, and Technical Operations to drive decision-making
• Translate scientific insights into actionable business and development strategies
• Contribute to the advancement of cell and gene therapy programs from early discovery through commercialization
• Present recommendations and insights to executive leadership, influencing enterprise priorities

By the end of the program, participants are equipped with the scientific, strategic, and leadership capabilities required to advance into director-level roles across the R&D organization.

At Legend Biotech, we believe our people are our greatest asset. This program reflects our unwavering commitment to professional development, career mobility, and long-term leadership growth; empowering early-career talent to take on meaningful challenges, expand their impact, and shape the future of our organization.

Requirements

• PhD required in Biological Sciences, Molecular Biology, Microbiology, Immunology, Biochemistry, Chemistry, Cell Biology, or related life sciences disciplines. 
• 7–10 years of industry experience in biotech, pharmaceutical, or related industry
• Demonstrated experience advancing scientific or clinical programs in R&D
• Proven ability to lead complex projects and collaborate across cross-functional teams
• Strong business acumen and ability to connect scientific work to broader org. strategy
• Experience in Cell Therapy preferred.
• Demonstrated record of scientific rigor, innovation, and cross-functional collaboration.
• Clear aspiration and potential to grow into scientific and enterprise leadership roles.

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Legend Biotech is seeking participants for Legend's Commercial Management Leadership Development Program as part of the Commercial team based in Somerset, NJ.

Role Overview

The Early Career Leadership Program at Legend Biotech is a strategic, enterprise-focused development experience designed to accelerate the growth of high-potential professionals early in their careers. Rooted in our commitment to cultivating enterprise-minded, value-driven leaders, this program provides structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions.

Join us in redefining what’s possible and build a career where your growth and patient impact go hand in hand.

Key Responsibilities

• The Commercial Management Hi-Po Leadership Development Program at Legend Biotech is a 2–3-year enterprise leadership accelerator designed for high-potential MBA graduates who aspire to shape the future of biotech commercialization. This program develops leaders capable of translating scientific innovation into meaningful patient access and market impact.
• Participants will complete three strategic rotations (8–12 months each) that may include Marketing, Market Access & Branding, Commercial Operations, Sales, and Business Insights & Analytics. Rotations are designed to provide both broad commercial exposure and the opportunity to pursue areas aligned with individual interests and development goals. Participants will develop the strategic, analytical, and leadership capabilities needed to influence commercial strategy and drive business growth
• This structured program integrates high-impact business experiences, executive mentorship, and a Leadership Development Series focused on developing leaders at every level — from leading self and others to influencing senior stakeholders and driving enterprise-wide business outcomes.
• At Legend Biotech, we believe our people are our greatest asset. This program reflects our unwavering commitment to professional development, career mobility, and long-term leadership growth; empowering early-career talent to take on meaningful challenges, expand their impact, and shape the future of our organization.

Requirements

• Recent MBA graduate (Class of 2023–2026)
• 3-5 years of professional experience demonstrating analytical and leadership capability.
• Background in life sciences, healthcare, marketing, sales, business analytics, or management consulting preferred.
• Strong analytical, communication, and strategic problem-solving skills.
• Demonstrated leadership potential and aspiration to grow into future commercial and enterprise leadership roles.

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Legend Biotech is seeking a HR Policy & Risk Manager (Contractor) as part of the Human Resources team based in Somerset, NJ.

Role Overview 

The HR Policy & Risk Manager plays a critical role in ensuring that HR operations and programs align with internal controls, external regulation and company risk management strategies. The role functions across multiple workstreams focused on risk identification, control implementation, policy compliance and internal auditing. This is a second line of defense role, providing oversight of HR risks, compliance and governance in alignment with broader enterprise risk management

Key Responsibilities

• Oversee the implementation and monitoring of controls across HR policies and processes, ensuring ownership by functional leads.
• Conduct quarterly control assessments and support function leads in evaluating control effectiveness.
• Lead or support internal HR audits, both scheduled and ad hoc, documenting findings and driving remediation actions.
• Monitor and assess HR risks using data-driven metrics (e.g., attrition, time-to-fill), investigate root causes and support resolution efforts
• Partner with reporting team to track HR risk indicators and ensure timely mitigation of emerging issues.
• Maintain oversight of employee investigations conducted to ensure objectivity and compliance monitoring.
• Monitor data privacy-related activities to ensure alignment with legal and regulatory standards
• Develop, maintain, and govern HR policies and procedures in accordance with internal standards and regulatory expectations.
• Own SOX-related HR controls, ensuring documentation, testing and remediation are completed accurately and on time.
• Contribute to company-wide compliance and risk management by representing HR-related risks.
• Prepare risk reports and audit summaries for HR leadership, internal audit and as needed.
• Serve as a central point of contact for HR risk, audit, and policy-related inquiries across the organization.
• Decides when to escalate HR risks, compliance issues, and investigation outcomes to leadership.
• Determines control priorities and remediation actions based on risk assessments and audit findings
• Evaluates and approves updates to HR policies, procedures, and SOX controls to meet regulatory and business needs.
• Identifies data trends and root causes to inform risk mitigation strategies.

Requirements

Education

• Bachelor’s degree in Human Resources, Business Administration, Risk Management, Compliance or a related field required.
• Master’s degree in HR, Business, Law, or a related discipline a plus.
• Relevant certifications preferred (e.g., PHR/SPHR, SHRM-CP/SCP, Certified Compliance & Ethics Professional – CCEP).

Experience

• Minimum of 5 years of experience in HR, compliance, internal audit, risk management or a similar function.
• Experience in a fast-paced professional environment and working with cross-functional teams.
• Strong understanding of risk management principles and compliance frameworks.
• Familiarity with HR systems, data privacy laws (e.g., GDPR, CCPA), and internal audit practices.
• Strong analytical skills to interpret HR metrics and identify trends or red flags.
• Excellent communication and stakeholder management, especially when partnering with HR, Legal, Audit, and Risk functions.
• High attention to detail, integrity, and ability to maintain confidentiality.
• Critical thinking and problem-solving mindset with a proactive approach to compliance.

IT Skills 

• Advanced Excel skills for data analysis and risk reporting (pivot tables, lookups, dashboards). 
• Proficiency with HRIS (Workday) and audit/compliance tools.
• Familiarity with data visualization or reporting tools (e.g., Power BI). 
• Experience with document management and workflow tools (e.g., SharePoint, SmartSheet).

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Legend Biotech is seeking a Manager, Site Contracts & Payments Management as part of the Clinical Operations team based in Somerset, NJ.

Role Overview

The Site Contracts & Payments Manager is responsible for site contracting and investigator payment process oversight and management, and vendor due diligence across Legend pipeline studies. The role serves as a central point of accountability for improving operational effectiveness, financial discipline, and sponsor-CRO-site workflow alignment for site contracting and payment processes.

Key Responsibilities

• Partner with CROs to develop and oversee process workflows, and create visibility into site contract and investigator payment workflow efficiency across studies.
• Partner with CROs, AP, Procurement, Finance, Legal, and study teams to align process workflows, identify gaps, and improve efficiency in contracting and payment execution.
• Monitor key milestones, bottlenecks, and escalations affecting site startup experience for contracting, payment timeliness, and financial predictability.
• Support reconciliation, issue resolution, and continuous improvement related to site contracting and investigator payment operations.
• Coordinate vendor due diligence and risk assessment activities with Procurement, Finance, QA, and other stakeholders.
• Performs other duties as required.

Requirements

• Minimum degree requirements of a bachelor’s degree (BA, BS) in scientific, health care, business, or related discipline. Advanced degree preferred.
• 7+ years of pharmaceutical, biotech, CRO, or related clinical research experience.
• Strong experience in vendor oversight, outsourcing, site contracts, investigator payments, or related operational functions required.
• Experience working cross-functionally with AP, Procurement, Finance, and Legal required.
• Experience working in SAP/4 Hanna preferred.
• Experience establishing KPIs and oversight models preferred.
• Oncology, cell therapy, or early-phase clinical operations experience preferred.
• Ability to travel as necessary (up to 10%).
• Effective oral, written, and interpersonal communication skills.
• Strong process management, organizational, and problem-solving skills.
• Ability to identify operational risk and drive practical mitigation strategies.
• Strong project management skills and the ability to manage multiple priorities.
• Computer literacy required (MS Word, MS Excel, MS PowerPoint, MS Project).
• Working knowledge of GCP, FDA, and ICH Guidelines.

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Legend Biotech is seeking a Chief Scientific Officer as part of the Research & Development team based in Somerset, NJ.

Role Overview

Legend Biotech is recruiting a visionary scientist, an accomplished drug hunter and a skilled organization/business leader as Chief Scientific Officer (CSO). The CSO will lead and oversee the global Research strategy and operations and is responsible for driving the scientific vision and overseeing research activities. The CSO is expected to deliver highly innovative and industrial-leading technology platforms and transformative therapies from initial concept to Development Candidate. Reporting to President of Research and Development, the CSO will be responsible for integrating all global technological innovation and drug discovery strategies and operations to bring cutting-edge therapies to patients.

Key responsibilities include developing and implementing the company’s scientific strategy, managing the Research budget, mentoring scientific staff, and collaborating with stakeholders to bring innovative products and solutions to the market. The CSO will also play a critical role in evaluating new technologies, partnerships, and investment opportunities.

This role requires a deep understanding of scientific principles, strong leadership skills, and the ability to translate complex research into actionable business strategies. As the CSO, you will work closely with executive leadership, product development teams, and external partners to drive innovation and maintain our position at the forefront of cell therapy. You will be expected to stay abreast of emerging trends and technologies, foster a culture of impactful innovation and scientific excellence, and ensure compliance with regulatory standards.

The ideal candidate should have a strong background in scientific research, preferably with a Ph.D. in a relevant field, and a proven track record of leading successful Research programs and delivering multiple compounds into clinic development. You should be skilled at managing global multidisciplinary teams and representing the company in scientific and regulatory forums.
This is a high-impact role that offers the opportunity to shape the future of our organization through scientific leadership and innovation. If you are an innovative scientist and an accomplished drug hunter and are passionate about science with the strategic vision to lead cutting-edge research, we encourage you to apply.

Key Responsibilities

• Develop disease centric global research strategy and deliver a robust, diversified and risk-balanced pipeline of therapeutics.
• Develop and implement global technology and drug discovery plans that align with the company’s business objectives, advancing the company’s pipeline of cell therapies from technology innovation to Development Candidates.
• Oversee global research programs through key milestones, including technological platform innovation and drug discovery, while efficiently managing resources to meet timelines.
• Manage global research budget and ensure resource allocation aligned with strategic priority and efficient return of investment.
• Drive the identification and evaluation of new technologies, research opportunities, partnerships, collaborations and licensing opportunities via BD to expand the company’s pipeline and market position.
• Attract, retain, and develop top talent within the global research organization, fostering a culture of innovation, collaboration, and scientific excellence.
• Serve as a key member of the executive leadership team, contributing to overall corporate strategy and decision-making.
• Stay abreast of industry trends, regulatory changes, and scientific advancements, ensuring compliance and maintaining the company’s leadership position in cell therapy development.

Requirements

• PhD or equivalent advanced degree in a relevant scientific field (e.g., immunology, oncology, molecular biology).
• Minimum of 15 years of experience in Research leadership roles within the biopharma and biotech industry, with a strong focus on cell therapy or immunotherapy.
• World-class scientific accomplishments demonstrated by a strong record of cutting-edge research publications and patents.
• Proven track record of successfully advancing multiple therapies from research through early clinical development.
• Extensive experience managing large, global, cross-functional teams and growing top talents.
• Deep understanding of the global development and regulatory landscape for cell and gene therapies.
• Strategic thinker with strong business acumen and the ability to align Research activities with overall company goals.
• Exceptional leadership and team-building skills, with a demonstrated ability to inspire and lead high-performing teams.
• Excellent communication, collaboration and interpersonal skills, with the ability to influence and engage a wide range of stakeholders.
• Strong analytic and problem-solving skills, with the ability to navigate complex challenges and drive decision-making in a fast-paced environment.

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Legend Biotech is seeking an Associate Director, Operations Program Lead as part of the Clinical Operations team based in Somerset, NJ.

Role Overview

The Operations Program Lead (OPL), Clinical Operations is accountable for accelerated operational delivery of 1-2 priority cell therapy development programs across all phases. This position is responsible for leading, managing and providing operational oversight for quality delivery within budget across all Legend Pipeline studies for 1-2 assets.

This individual must be able to work and lead in a small, fast-paced environment while also wearing multiple hats at any given time as the needs of the organization change and evolve. This position requires a high-performing contributor with strong leadership and stakeholder management skills. This individual will collaborate with the cross functional team to develop operationally feasible program timelines and identify clinical trial operational risks and develop mitigation strategies to ensure accelerated and cost-efficient quality clinical trial execution.  In addition, the position will ensure program consistency across studies, drive research and operational excellence through process improvement, and represent the clinical trial operation function at internal and external meetings.

This position will oversee 1-2 contractor Clinical Trial Associates (CTA).

Key Responsibilities

Direct end-to-end clinical trial management: 

• Direct end-to-end clinical trial operations activities domestically and globally: i.e. lead and take ownership in all aspects of Study Operations for CAR-T Studies in a matrix environment.
• Responsible for the overall success of the clinical study programs
• Ensures the assigned clinical trials are executed in compliance with FDA and ICH/GCP guidelines/regulations and SOPs. Ensures audit-ready condition of clinical trial documentation including central clinical files.
• Report on all aspects of the study progress at a granular level to stakeholders and senior leaders. Effective, consistent & regular tracking of project (s). Prepare and present project reports as required. Plans, executes, and leads study-specific meetings as needed (e.g., Senior and Mid-level management Study Management Meetings).
• Supports the Development of strategic plans for clinical trial operations, ensuring alignment with the company's overall goals and objectives.
• Collaborate with the cross-functional "core" teams to integrate clinical operations strategies into broader development plans.
• Define project timelines & deliverables, by working closely with the cross-functional core program team for end-to-end execution of clinical trials.
• Collaborates in the preparation and/or review of study-related documents (e.g., study protocols, informed consents and amendments, Study Operations Plan, Monitoring Plan, Pharmacy Manual, Informed Consent, Laboratory Manual, CRF Completion Guidelines, study tools/worksheets and other study-specific documents or manuals).

Clinical Trial Operations Efficiency and optimization:

• The OPL will drive clinical Operations excellence by playing a critical role in Clinical Trial Operations Efficiency and optimization.
• Work with cross-functional teams and external vendors to identify clinical trial operational risks and develop mitigation strategies to ensure quality delivery of the clinical trial to support optimal and efficient clinical trial execution. 
• The position involves working closely with the clinical development team and collaboration with cross-functional teams, including safety, study monitoring and coordinators, data management, biostatistics, bio analytics, tech ops, manufacture, supply chain, regulatory, project management, medical affairs, finance, legal and quality.
• Create and Manage study trial execution RACI to support overall trial execution and operational excellence.
• Contribute to Clinical Operations functional initiatives and institution of best practices.

Resource Management and Direct High Performing team:

• Manage and build a high-performing clinical operations support structure. Duties include hiring, onboarding, training, and development of staff to manage studies.
• Lead, develop and manage study operation manual, new work-streams, SOPs, study template, tracking tools, dashboards to support optimal clinical operation performance.
• Provides study-specific training and leadership to clinical research staff, including CRO, sites and other study personnel to support clinical trial execution and optimization.

Direct and Support Vendor Partnership

• Oversee vendor selection process, management, of Contract Research Organizations (CROs) and vendors involved in clinical trial Operation (CRO, Central Lab, etc).
• Participates in CRO and vendor study related calls and meetings, holds team members accountable for actions, escalates issues and oversees all aspects of daily study operations. Ability to identify issues and risks. Develops and manages mitigations and/or escalate risks appropriately.
• Negotiates vendor contracts / budgets and presents to the executive study team for approval.
• Review and confirm CRO and site payment invoices.
• Lead vendor performance assessment for continuous process improvement
• Management/oversight of external vendor deliverables reports and budgets.
• Collaborate within Clinical Operations and with study leadership team to create preferred vendor list for clinical development.

Leadership Skills

• Has critical thinking skills for problem solving and have the lateral and strategic thinking capacity to drive the study(ies) and understand the upstream, downstream, and lateral implications of decisions that affect study outcomes and timelines.
• Adaptable / flexible, self-starter (willing and able to adjust to multiple demands and shifting priorities; ability to meet day-to-day challenges with confidence and professionalism)
• Excellent team player: willingness and ability to fill functional gaps in a small organization.
• Comfortable multi-tasking in a fast-paced small company startup environment and able to adjust workload based upon changing priorities.

Key Relationships

• The Operations Program Lead in Clinical Operations works closely with the asset Core Team and cross-functional teams such as safety, study monitoring, data management, biostatistics, bioanalytics, manufacturing, supply chain, regulatory, project management, medical affairs, and quality.
• Mentoring and management of a CTA.

Requirements

• Minimum degree requirements of a bachelor’s degree (BA, BS) in scientific or health care discipline. Advance Degree Preferred.
• Oncology and/or Immunology clinical trial operations therapeutic experience required. 10+ years of pharmaceutical, biotech or CRO related/ oncology clinical research experience.
• Experience leading the operational planning and oversight of clinical trials as the point of accountability for operational delivery. (CAR-T trials experience is a plus).
• Demonstrated ability to deliver ambitious trial acceleration timelines within a competitive clinical trial landscape.
• Phase 1 clinical trial operational experience is preferred.
• Experience and knowledge of end-to-end management of clinical trial conduct, knowledge of the pharmaceutical industry and an understanding of clinical drug development, clinical trials operations and FDA/ICH regulatory requirements are essential.
• This position requires experience and leading study/project management to create study project plans, and end-to end-study timelines for execution of clinical trials.
• Demonstrated ability to multi-task and manage high performance demands.
• Excellent organizational skills, ability to manage multiple tasks and meticulous attention to detail.
• CRO/Vendor oversight experience required.
• Project Management (biotech) experience a plus.
• Regulatory authority inspection experience a plus.
• Ability to travel as necessary (approximately 10 – 15 %); both domestically and internationally.
• Effective oral, written and interpersonal communication skills.
• Strong communication and presentation skills.
• Forward and critical thinker.
• SOP development experience preferred.
• Strong organizational and project management skills, and the ability to multitask.
• Computer literacy required (MS word, MS excel, MS PowerPoint and MS Project).
• Excellent working knowledge GCP, FDA and ICH Guidelines.

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Legend Biotech is seeking a Principal Scientist, Lentivirus Downstream Process Development as part of the Technical Development team based in Somerset, NJ.

Role Overview

The Principal Scientist, Lentivirus Downstream Process Development, will be a key technical leader responsible for designing, optimizing, and scaling purification processes for lentiviral vectors (LVV) within our innovative pipeline. This role focuses on delivering high-quality vector products to support LVV generation and other advanced cell therapy programs. The successful candidate will drive scientific excellence in downstream processing (DSP)—including clarification, chromatography, TFF, sterile filtration and fill/finish—ensuring processes are robust, scalable, and phase-appropriate for GMP manufacturing. This position demands a blend of hands-on technical mastery and strategic thinking to accelerate timelines while maintaining a patient-focused approach.

Key Responsibilities

• Design and execute highly efficient purification strategies for lentiviral vectors, specifically optimized for CAR-T applications.
• Direct the development and optimization of downstream processes including and not limited to: clarification (depth filtration, centrifugation), chromatography (AEX, SEC, HIC), and Tangential Flow Filtration (TFF) for concentration and diafiltration.
• Provide hands-on training as needed.
• Direct the translation of bench-scale processes to GMP manufacturing, ensuring seamless technology transfer and providing troubleshooting support during clinical production runs
• Lead the execution of study protocols to define operating parameters and performance limits; implement state-of-the-art knowledge management for DSP data.
• Communicate the potential for issues and delays along with solutions and mitigation approaches.
• In collaboration with the Senior Leaders, CMC Project Manager, Project Leader, and other technical leads identify project acceleration opportunities.
• Leverage advanced science and technology to maximize vector recovery, purity, and potency, identifying creative solutions to define unknowns in the viral vector field.
• Guide a team of scientists in the execution of project-specific activities, fostering a culture of transparency, scientific rigor, and continuous improvement.
• Author and serve as a primary reviewer for technical documents, including development reports, SOPs, and CMC sections for regulatory submissions (IND/IMPD).
• Work closely with Upstream Process Development and Analytical Development teams to ensure integrated and holistic process outcomes.
• Tech transfer process to/from other Legend sites or CDMOs
• Resolve conflict and proactively identify/address performance issues.
• Ensure compliance with regulatory requirements. 

Requirements

• Advanced degree (PhD preferred, or MS) in Chemical Engineering, Biomedical Engineering, Virology, Molecular Biology, or a related field.
• 8+ years (PhD) or 10+ years (MS) of experience in process development or manufacturing within a biotech or pharmaceutical setting.
• Deep technical hands-on experience in purification, chromatography, and TFF specifically for viral vectors (Lentivirus preferred)
• Strong understanding of GMP manufacturing requirements and CMC strategies for early-phase clinical trials.
• Deep knowledge and hands-on experiences in cell and lentiviral vector technologies within the current emerging field
• Ability to implement closed-system processes and maximize cost effectiveness
• Strong knowledge in engineering modeling and optimization.
• Excellent leadership, emotional intelligence, and communication skills; ability to maintain composure and strategic focus during challenging development timelines.
• Creative, strategic thinking
• Strong troubleshooting skills
• Preferred experience in developing vector processes tailored for CAR-T generation and systemic delivery
• Preferred experience in handling large scale(>50L) purification process.
• Language: English. Mandarin is a plus. 

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Legend Biotech is seeking a Manager, Competitive Intelligence as part of the Commercial team based in Somerset, NJ.

Role Overview

The of Competitive Intelligence (CI) will serve as a strategic thought partner responsible for generating actionable insights that inform decision-making across R&D, commercial, and corporate strategy functions. This individual will lead proactive and on-demand CI initiatives, including competitor monitoring, landscape assessments, early signal detection, conference surveillance, and strategic analysis that supports pipeline development, lifecycle management, and long-term planning. The ideal candidate is a highly analytical, collaborative, and business-oriented professional with strong communication skills and a deep understanding of the biopharmaceutical landscape.

Key Responsibilities

Strategic Intelligence & Insight Generation

• Lead competitive intelligence activities across assigned therapeutic areas, platforms, and/or programs, delivering high-quality, actionable insights to senior leadership and cross-functional stakeholders.
• Conduct comprehensive landscape assessments, including scientific, clinical, regulatory, and commercial dimensions.
• Monitor competitors’ pipelines, clinical data, regulatory actions, collaborations, and market events to identify emerging threats, opportunities, and early signals.
• Monitor new entrants and startup tracking: Monitoring early innovation signals, investments, and disruptive players
• Synthesize complex data into clear narrative insights and strategic recommendations.

Conference Coverage & Surveillance

• Lead end-to-end conference CI planning and execution, including surveillance plans, abstract triage, onsite (or virtual) monitoring, rapid-readouts, and post-conference summaries.
• Coordinate cross-functional stakeholders to ensure aligned priorities and actionable outputs.

Data & Analysis Leadership

• Build and maintain CI frameworks, dashboards, market landscapes, and tracking systems to support continuous monitoring.
• Manage internally created CI dashboard and in some cases external CI vendors and ensure high-quality deliverables aligned with business needs.
• Develop and implement CI best practices, tools, and standardized processes.

Cross-Functional Partnership

• Serve as CI lead for R&D, commercial, BD, and strategy teams; participate in team meetings and strategic discussions as an insights partner.
• Partner with forecasting, medical affairs, and commercial strategy to ensure cohesive interpretation of external environment dynamics.
• Required to make decisions on a day-to-day operations for their tasks, and technicalities related to CI mostly. 

Requirements

• Master’s in life sciences, business, or related field
• 3+ years of experience in pharmaceutical/biotech competitive intelligence, strategy, consulting, market research.
• Strong scientific and clinical acumen in relevant therapeutic areas; hematology/oncology and Autoimmune experience preferred (if applicable).
• Demonstrated track record of delivering strategic insights and influencing decision-making.
• Strong analytical and strategic thinking abilities.
• Excellent written and verbal communication skills; ability to distill complex information into clear insights.
• Highly proficient in CI methodologies, secondary research, data interpretation, and triangulation.
• Skilled at working in fast-paced, cross-functional environments with tight timelines.
• High integrity and ability to manage sensitive/confidential information.
• Familiarity with CI tools, databases, and information platforms (e.g., Evaluate, Cortellis, Datamonitor, Alphasense, and clinical databases). 

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Legend Biotech is seeking a Sr. Manager, Clinical Trial Operations Planning & Analytics as part of the Clinical Operations team based in Somerset, NJ.

Role Overview

The Sr. Manager, Clinical Trial Operations Planning & Analytics is responsible for the strategic planning and analytics capability to support current and future Legend pipeline studies. This role will establish scalable approaches for feasibility, site identification, study startup planning, forecasting, and trial performance analytics to improve predictability and enable earlier operational intervention. The position partners closely with Clinical Operations leadership and cross-functional stakeholders to determine and assess assumptions, refine strategy, and translate data into actionable operational decisions across the study lifecycle.

Key Responsibilities

• Lead development of standardized frameworks, tools, and processes for feasibility, site identification, enrollment forecasting, study startup planning, and predictive trial performance modeling across pipeline studies.
• Develop data-driven approaches to identify the right countries and sites globally to support activation and enrollment acceleration and to predict key operational outcomes such as startup timing, enrollment, and study completion.
• Build scenario models and planning outputs to support base and best case operational strategies and contingency planning.
• Establish contingency planning triggers, risk indicators, and escalation thresholds based on modeled performance risk.
• Partner with study teams, CROs, and cross-functional stakeholders to pressure-test trial assumptions and refine country and site strategies.
• Create and maintain dashboards and analytics to monitor startup, activation, enrollment, and delivery risk trends.
• Translate study and portfolio performance data into actionable insights and executive-ready recommendations for senior leadership.
• Support continuous refresh of assumptions as study conditions, portfolio priorities, and external dynamics evolve.
• Capture lessons learned and convert them into reusable planning tools, templates, and methodologies that improve cross-study consistency.
• Represent the function in internal planning discussions and external partner interactions related to feasibility, forecasting, and performance analytics.
• Performs other duties as required.
• Works closely with the Sr. Director and VP of Clinical Operations. Clinical Operations Capabilities & Scalability and collaborates with Clinical Operations study teams, Clinical Development, IT, ITQA Biostatistics, Regulatory, Project Management, Procurement, Finance, QA, and CRO/vendor.

Requirements

• Minimum degree requirements of a bachelor’s degree (BA, BS) in scientific, health care, data, or related discipline. Advanced degree preferred.
• 7+ years of pharmaceutical, biotech, CRO, or related clinical research experience; 10+ years preferred.
• Experience working with data sources to inform trial forecast modeling
• Experience in clinical operations planning, feasibility, study startup, operational analytics, or related functions required.
• Experience supporting global site identification, country strategy, or enrollment planning strongly preferred.
• Experience building dashboards, models, or analytics to support clinical trial execution preferred.
• Oncology, cell therapy, or early-phase clinical development experience preferred.
• Ability to travel as necessary (approximately 10%).
• Knowledge/familiarity with tools to enable trial forecasting and modeling.
• Strong critical thinking, analytical, strategic planning, and problem-solving skills.
• Effective oral, written, and interpersonal communication skills with strong presentation capability.
• Forward and critical thinker with ability to translate data into decisions.
• Strong organizational and project management skills and the ability to multitask.
• Computer literacy required (MS Word, MS Excel, MS PowerPoint, MS Project, and analytics/visualization tools).
• Working knowledge of GCP, FDA, and ICH Guidelines.

#Li-AS1

#Li-Hybrid

Legend Biotech is seeking a Sr. Director, EHS, Facilities Management & Engineering as part of the Facilities & Engineering team based in Somerset, NJ.

Role Overview

The Sr. Director, Facilities, Services & Engineering is the senior leader responsible for the strategy, operation, and performance of all Legend Biotech facilities including GMP manufacturing sites, laboratories, corporate offices, administrative buildings, and shared global infrastructure. This role ensures reliable, safe, compliant, and efficient operations across utilities, engineering, building systems, environmental services, capital project execution, and workplace/office services.
The Sr. Director leads the integrated facilities and engineering organization to support manufacturing, clinical operations, R&D, and corporate growth while ensuring world-class employee experience and operational excellence.

Key Responsibilities

Enterprise Facilities Leadership (GMP & non-GMP)

• Lead facilities operations for all Legend Biotech locations, including manufacturing sites, labs, offices, leased spaces, and new buildouts.
• Ensure consistent service levels, standardized processes, and high reliability across all facilities.
• Oversee building infrastructure (HVAC, electrical, plumbing, security systems, life safety, landscaping, and workplace environments).
• Maintain compliance with global regulatory, corporate, and local building & safety requirements.

GMP Facilities & Utilities

• Oversee critical GMP utilities: HVAC, cleanrooms, water treatment , clean steam, compressed gases, BMS/EMS, controlled environments.
• Ensure validated state and audit readiness at all times.
• Partner closely with Manufacturing, Quality, and EHS to maintain uninterrupted production.

Engineering & Equipment Reliability

• Lead engineering support for equipment lifecycle management across GMP and non-GMP areas.
• Manage maintenance strategy, calibration programs, CMMS utilization, and reliability initiatives.
• Support equipment readiness for tech transfers, automation upgrades, and expansion projects.

Corporate Offices & Workplace Services

• Oversee all corporate office environments, including:
  
  • Office operations
  • Workspace planning & allocation
  • Security & access control
  • Janitorial, cafeteria, reception, and mailroom services
  • Vendor management for furniture, workspace design, and site amenities
• Ensure a high-quality, safe, ergonomic, and productive work environment for employees.

Site Services

• Manage site-wide services including waste management, hazardous waste, groundskeeping, shipping/receiving, warehousing, sustainability initiatives, and emergency response planning.
• Ensure a consistent service model across all locations.

Capital Projects & Expansion

• Lead planning and execution of multi-million-dollar capital projects including new facilities, office expansions, GMP cleanroom construction, laboratory constructions , and infrastructure upgrades.
• Oversee feasibility studies, scope definition, construction, commissioning, and handover.

Strategic Planning & Budget Management

• Develop a global facilities & engineering strategy aligned with Legend’s growth trajectory.
• Lead multi-year capital planning, operational budgeting, vendor strategy, and cost optimization.
• Ensure business continuity and long-term capacity planning.

Leadership & People Development

• Build and lead a high-performing, diverse team across facilities, engineering, site operations, and workplace management.
• Drive a culture of safety, inclusion, collaboration, and continuous improvement.
• Ability to interact with all levels within the global organization. Build strong relations with functions and leaders across our organization.

Requirements

• Bachelor’s degree in Engineering, Facilities Management, Architecture, or related field.
• 10+ years of progressive leadership in GMP facilities/engineering within biopharma, plus experience leading office/corporate facilities.
• Deep understanding of GEP/GMP, critical utility systems, commissioning/qualification, building systems, and regulatory expectations.
• Experience managing large capital projects and multi-site operations.
• Strong vendor management, budget ownership, and cross-functional leadership experience.
• Strategic facility & engineering leadership.
• Technical depth in GMP operations and building management.
• Strong communication and stakeholder engagement.
• Financial acumen and project governance.
• Organizational planning & change leadership.
• Ability to manage complexity across manufacturing and office environments.

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#Li-Onsite

Legend Biotech is seeking a Manager, Talent Acquisition, Carvykti as part of the Talent Acquisition team based in Somerset, NJ.

Role Overview

The Manager, Talent Intelligence & Sourcing enables HR teams to drive business growth by delivering strategic insights, strengthening global sourcing capabilities, and leading organizational talent strategy initiatives. This role plays a critical part in developing data-informed recruitment strategies, building scalable systems, and fostering strong partnerships with TA teams, HRBPs, Global HR CoEs, and business leaders.

The ideal candidate is highly independent, analytical, and solution-oriented, with deep curiosity for talent movement. This individual will lead efforts to translate complex talent market data into actionable strategies while overseeing key initiatives such as external succession planning and competitive intelligence. The role also includes leadership and development of the sourcing team to enhance Legend Biotech’s global direct sourcing capability.

Key Responsibilities

• Develop talent market intelligence by analyzing talent trends, competitive landscapes, and talent pool availability across key geographies and functions.
• Provide interpretation of market intelligence and assess its implications for hiring strategies, workforce planning, and business competitiveness.
• Monitor global labor market shifts and recommend strategic adjustments to maintain a competitive edge in attracting and retaining top talent.
• Use internal and external data to shape talent acquisition strategies and inform long-term workforce planning.
• Lead the External Succession Planning initiative, evaluating external talent pipelines for critical roles and providing insights to influence leadership succession decisions.
• Own and expand Competitive Intelligence efforts, delivering insights on competitor hiring behaviors, talent movements, organizational structures, and labor market positioning.
• Collaborate with senior HR and business stakeholders to integrate Talent Intelligence insights into broader talent strategies and decision-making frameworks.
• Manage, mentor, and develop the global sourcing team to enhance Legend Biotech’s direct sourcing capability and operational excellence.
• Design and implement scalable sourcing strategies aligned with Legend’s long-term talent needs.
• Partner with regional TA leads and recruiters to strengthen global sourcing capabilities and support high-impact hiring outcomes.
• Leverage talent data and skills analysis to determine optimal sourcing channels and build diverse pipelines of critical talent.
• Embed market insights into recruiter and sourcer workflows, developing training and tools to elevate sourcing effectiveness.
• Build and evolve the infrastructure, tools, and systems required for a scalable, best-in-class Talent Intelligence function.
• Collaborate on workforce forecasting frameworks to enable accurate projections of global hiring needs.
• Develop compelling communication strategies to share market insights with senior stakeholders and influence hiring strategies.
• Educate TA teams and business leaders on talent trends, industry benchmarks, best practices, and emerging TA technologies.

Requirements

• A bachelor’s degree is required in a relevant field.
• Minimum 6 years of relevant experience, Pharmaceutical/Biotech industry experience is preferred.
• Experience in Talent Intelligence, corporate research, talent analytics, consulting, or related strategic roles is preferred.
• Experience managing or mentoring a sourcing or research team is strongly preferred.
• Ability to learn new technology and domains, and quickly understand and apply this knowledge into strategies for Talent Acquisition teams.
• Ability to effectively engage the attention of stakeholders and articulate complex arguments in a polished and professional manner.

#Li-ML1

#Li-Hybrid

Legend Biotech is seeking an Exploratory Technology Intern as part of the Exploratory Technology team based in Somerset, NJ.

Role Overview

The Exploratory Technology Intern will gain hands-on exposure to cutting-edge research within a leading cell therapy organization. Working alongside experienced and highly accomplished scientists, the intern will learn how innovative cell therapy products are designed, engineered, and developed within the pharmaceutical industry. In addition to laboratory and project-based learning, the intern will participate in journal clubs and group discussions, providing further opportunities to explore scientific literature and engage with ongoing research initiatives.

Key Responsibilities

• Perform laboratory experiments under the guidance and supervision of the assigned mentor.
• Prepare experimental plans, maintain accurate laboratory records, and contribute to study reports with mentor oversight.
• Present research progress and findings during lunch-and-learn sessions, lab meetings, and the final internship presentation.
• The intern will be selected based on technical competency, motivation, and professional attributes. Key considerations include proficiency in basic wet‑lab skills, willingness to learn advanced techniques, and ability to follow guidance while maintaining accurate records.
• Candidates who demonstrate curiosity, passion for scientific research, and strong work ethics—such as diligence, reliability, and honesty—will be prioritized. The final decision will be made jointly by the mentor and project team to ensure alignment with project needs and team culture. 

Requirements

• Undergraduate student majoring in biology, biomedicine, bioengineering or related area.
• The student should possess fundamental wet-lab skills, including cell culture, cell passaging, flow cytometry, and basic molecular biology techniques. Experience with assays such as ELISA, cytokine profiling using MSD, or ddPCR is preferred.
• We seek a student who is intellectually curious, passionate about scientific research and drug development, and motivated to pursue a long-term career in this field.
• The ideal candidate is diligent, reliable, and honest, with the ability to take ownership of assigned tasks and consistently meet expectations. 

#Li-JR1

#Li-Contract

Legend Biotech is seeking a Sr. Principal/Principal Scientist as part of the Research & Early Development team based in Somerset, NJ.

Role Overview

Legend Biotech is seeking a highly experienced Senior Principal Scientist / Principal Scientist – Flow Cytometry to provide scientific leadership and hands-on expertise in flow cytometry to support cell and gene therapy programs from IND-enabling studies through early- and late-stage clinical development. This role is critical for ensuring scientific rigor, data quality, and strategic insight across in-house and outsourced flow cytometry activities, including assay development, validation, CRO oversight, and deep data interpretation to support translational, PK/PD, and regulatory decision-making.

Key Responsibilities

Scientific & Technical Leadership

• Lead the design, development, optimization, qualification, and validation of multicolor and spectral flow cytometry assays supporting IND-enabling animal studies and clinical trials.
• Provide subject-matter expertise in panel design, antibody and reagent qualification, gating strategies, and data analysis for complex immunophenotyping applications.
• Conduct deep scientific review and interpretation of flow cytometry datasets to support PK/PD, mechanism-of-action, and translational insights.

CRO & Vendor Oversight

• Serve as the primary scientific lead for external laboratories and CROs performing flow cytometry assays.
• Oversee assay transfer, validation, execution, troubleshooting, and data delivery at CROs.
• Ensure outsourced activities meet Legend quality standards, regulatory expectations, and program timelines.
• Identify risks related to assay performance, data quality, and operational execution, and implement mitigation strategies.

Regulatory & Compliance

• Author, review, and approve bioanalytical assay validation reports, study reports, and regulatory documentation.
• Ensure flow cytometry assays and data packages are inspection-ready and compliant with GxP principles and data integrity requirements.
• Contribute to bioanalytical sections of IND and other regulatory submissions.

Cross-Functional Collaboration

• Partner with Clinical, Translational Research, Biomarkers, Nonclinical Safety, and Data Science teams to align assay strategy with program objectives.
• Provide scientific input to study design, endpoint selection, and interpretation of bioanalytical results.
• Communicate complex data clearly to multidisciplinary stakeholders.

Operational Excellence & Mentorship

• Establish and maintain SOPs, best practices, and governance for in-house flow cytometry workflows.
• Mentor and scientifically guide junior scientists and associates.
• Evaluate and implement new technologies, platforms, and analytical approaches to enhance capabilities.

Requirements

• Ph.D. in Immunology, Cell Biology, Molecular Biology, or related discipline with 8+ years (Principal Scientist) or 10+ years (Senior Principal Scientist) of relevant industry experience; or M.S. with 12+ years of experience.
• Extensive hands-on experience with multicolor and spectral flow cytometry platforms.
• Demonstrated experience supporting cell therapy and/or gene therapy programs.
• Strong understanding of bioanalytical method development, validation, and regulatory expectations.
• Proven ability to lead complex programs, influence cross-functional teams, and provide strategic scientific direction.
• Experience overseeing CROs and external vendors.
• Excellent written and verbal communication skills.
• Experience with CAR-T, in vivo gene delivery, or other advanced cell therapy platforms.
• Experience contributing to IND-enabling or regulatory filings.
• Background in translational PK/PD applications of flow cytometry. 

#Li-JR1

#Li-Onsite

Legend Biotech is seeking an Associate Director, Corporate Strategy & Competitive Intelligence as part of the Commercial team based in Somerset, NJ.

Role Overview

The Associate Director of Competitive Intelligence (CI) will serve as a strategic thought partner responsible for generating actionable insights that inform decision-making across R&D, commercial, and corporate strategy functions. This individual will lead proactive and on-demand strategic initiatives, including internal KPI management, CI monitoring, landscape assessments, early signal detection, conference surveillance, and strategic analysis that supports pipeline development, lifecycle management, and long-term planning. The ideal candidate is a highly analytical, collaborative, and business-oriented professional with strong communication skills and a deep understanding of the biopharmaceutical landscape.

Key Responsibilities

• Conducting value stream mapping to identify inefficiencies and areas for improvement.
• Developing, implementing, and sustaining lean transformation strategies aligned with business objectives.
• Establishing and monitoring KPIs to track continuous improvement efforts.
• Collaborating with leadership to prioritize improvement opportunities and allocate resources.
• Lead competitive intelligence activities across assigned therapeutic areas, platforms, and/or programs, delivering high-quality, actionable insights to senior leadership and cross-functional stakeholders
• Monitor competitors’ pipelines, clinical data, regulatory actions, collaborations, and market events to identify emerging threats, opportunities, and early signals.
• Monitor new entrants and startup tracking: Monitoring early innovation signals, investments, and disruptive players
• Assist CI partners with end-to-end conference CI planning and execution, including surveillance plans, abstract triage, onsite (or virtual) monitoring, rapid-readouts, and post-conference summaries.
• Build and maintain CI frameworks, KPI dashboards, market landscapes, and tracking systems to support continuous monitoring.
• Assist in managing internally created CI dashboard and in some cases external CI vendors and ensure high-quality deliverables aligned with business needs.
• Serve as collaborator with R&D, commercial, BD, and strategy teams; participate in team meetings and strategic discussions as an insights partner.
• Partner with forecasting, medical affairs, and commercial strategy to ensure cohesive interpretation of external environment dynamics.
• Requires autonomy in making decisions related to day-to-day operations and their technical aspects mostly.

Requirements

• Advanced degree preferred (PhD, PharmD, MD, or Master’s in life sciences, business, or related field).
• 5+ years of experience in pharmaceutical/biotech competitive intelligence, strategy, consulting, market research.
• Strong scientific and clinical acumen in relevant therapeutic areas; hematology/oncology/IAI experience preferred (if applicable).
• Relevant certification in Six Sigma (Green Belt/Black Belt) or Lean Management.
• Experience with coding, use of R scripts, python and pivot tables is required.
• Strong analytical and strategic thinking abilities.
• Excellent written and verbal communication skills; ability to distill complex information into clear insights.
• Experience with coding, use of R scripts, python and pivot tables is required. Highly proficient in CI methodologies, secondary research, data interpretation, and triangulation.
• Skilled at working in fast-paced, cross-functional environments with tight timelines.
• High integrity and ability to manage sensitive/confidential information.
• Familiarity with CI tools, databases, and information platforms (e.g., Evaluate, Cortellis, Datamonitor, Alphasense, and clinical databases). 

#Li-LB1

#Li-Hybrid

Legend Biotech is seeking a Manager, Talent Acquisition, Carvykti as part of the Talent Acquisition team based in Somerset, NJ.

Role Overview

The Manager, Talent Acquisition, Carvykti, will act as a strategic advisor to business and HR leaders in support of Legend Biotech’s Pipeline functions. This individual will own and execute talent acquisition strategies across critical functions within Carvykti Business, driving business outcomes through proactive, data-driven recruitment. This individual will partner closely with HRBPs and hiring teams to ensure Legend attracts, engages, and hires top talent.

Key Responsibilities

• Partner with Carvykti business leaders, as well as HR Business Partners (HRBPs), to understand workforce plans, organizational design, and capability needs, translating them into actionable talent acquisition strategies.
• Lead full-cycle recruitment for critical and technical roles across Carvykti business, ensuring a streamlined, candidate-centric experience from intake through offer.
• Develop and execute proactive, data-informed sourcing strategies to attract high-caliber, mission-aligned talent in a highly competitive life sciences market.
• Provide insights on talent market trends, availability, and compensation benchmarks to influence hiring strategies and workforce planning decisions.
• Manage search engagements, both internally and through external partners, with accountability for candidate quality, process integrity, and stakeholder satisfaction.
• Partner closely with HRBPs and hiring managers to build diverse, high-performing teams while delivering a consistent and positive hiring manager and candidate experience.
• Manage Carvykti business recruiting team members, including workload management, day-to-day coaching, and performance feedback.
• Educate and coach hiring teams on structured interviewing techniques, recruitment strategy, and effective selection practices to ensure consistency and mitigate bias.
• Drive compliance with internal recruiting processes and external regulatory standards; collaborate with HR and TA Operations to address issues and continuously improve practices.
• Track and analyze key recruitment metrics (e.g., time-to-fill, source effectiveness, candidate quality) to identify areas for optimization and report insights to stakeholders.
• Collaborate with TA Operations and Talent Intelligence to build hiring dashboards and deliver actionable reporting to business and HR leaders.
• Partner with TA Marketing and TA leadership on talent attraction campaigns, university or industry events, and relationship-building with strategic talent pools.
• Represent Legend Biotech at relevant industry events, executive forums, and professional networks to elevate the company’s employer brand and strengthen long-term pipelines for critical and leadership roles.
• This role operates with a moderate to high level of autonomy, with responsibility for both strategic and tactical decision-making within the scope of talent acquisition for Carvykti business. The incumbent is expected to exercise sound judgment, independently manage priorities, allocate resources, and lead initiatives aligned with business goals and the broader Talent Acquisition (TA) strategy.
• The role will oversee recruitment-related budgets associated with search engagements within approved financial parameters. The incumbent is responsible for effective resource planning, including workload distribution across team members and managing external search partners to ensure cost-effective, high-quality outcomes.
• Oversight and higher-level approvals are required for decisions that have significant financial impact, represent strategic shifts in direction, or involve policy changes with broader organizational implications

Requirements

• A bachelor’s degree is required, preferably in Human Resources, Business, or a related field.
• Minimum of 6 years of talent acquisition experience, including at least 1 years in an external search firm and/or recruiting talent within the pharmaceutical or biotech industry.
• Proven experience developing and executing strategic recruitment initiatives.
• Deep understanding of full-cycle recruitment, advanced sourcing strategies, and current talent market trends.
• Strong analytical skills, with the ability to leverage data to inform decisions, identify patterns, and optimize recruitment effectiveness.
• Excellent project management capabilities, with a track record of leading or contributing to complex recruitment projects and cross-functional initiatives.
• Demonstrated ability to adapt and succeed in a fast-paced, dynamic environment while effectively managing multiple competing priorities.
• Skilled in creating talent acquisition reports and presentations to support decision-making.
• Proficiency in Applicant Tracking Systems (ATS), preferably Greenhouse or Workday; experience with recruitment marketing platforms is a plus.
• Proficiency in Microsoft Office Suite with the ability to analyze and present recruitment metrics, dashboards, and market insights.
• Extensive hands-on experience with LinkedIn Recruiter and sourcing platforms such as SeekOut, BrightHire, and LinkedIn Talent Insights, with the ability to translate insights into actionable sourcing strategies.
• Proven ability to leverage AI-powered tools and recruitment technologies to enhance candidate engagement, improve recruiter productivity, and drive data-informed hiring decisions.
• Comfortable adopting and integrating new sourcing and talent intelligence platforms to support proactive planning and competitive talent mapping.

#Li-ML1

#Li-Hybrid

Legend Biotech is seeking a Manager, Talent Acquisition, Carvykti as part of the Talent Acquisition team based in Somerset, NJ.

Role Overview

The Manager, Talent Acquisition Operations, is a key enabler of a high-performing, compliant, and data-driven global Talent Acquisition (TA) organization. This role oversees operational excellence across all recruiting processes, systems, and vendor partnerships, ensuring a consistent, efficient, and scalable candidate and stakeholder experience. Acting as the central link between TA, HR, Finance, Procurement, IT, and other business partners, the incumbent drives process optimization, recruiter enablement, and technology innovation to support Legend Biotech’s growth worldwide.

Key Responsibilities

• Oversee daily TA operations, ensuring seamless execution of recruiting activities including job posting, job audit, interview logistics, candidate travel coordination, and pre-boarding activities.
• Serve as the central operations hub for TA, supporting recruiters and hiring teams to ensure end-to-end delivery excellence.
• Maintain and continuously improve standard operating procedures (SOPs), policies, templates, and process documentation to ensure consistency and compliance across all regions.
• Manage escalations related to system issues, process gaps, or service delays to ensure swift resolution and business continuity.
• Design, standardize, and continuously refine TA workflows to improve scalability, compliance, and stakeholder experience.
• Drive process automation, leveraging AI and digital tools to reduce manual work and accelerate recruitment cycle time.
• Establish and enforce data governance standards across the TA lifecycle; ensure compliance with internal audit, legal, and privacy requirements.
• Lead process audits, identify pain points, and implement structured feedback mechanisms to drive continuous improvement.
• Act as global system owner for the TA tech stack (e.g., Greenhouse ATS, assessment, scheduling, and other TA tools).
• Lead implementations, integrations, troubleshooting, and system deployment/enhancements aligned with business needs.
• Deliver user enablement through documentation, training, and toolkits that enhance recruiter and coordinator productivity.
• Research and pilot innovative tools that elevate the TABP, candidate, and hiring manager experience (e.g., chatbots, AI sourcing, analytics dashboards).
• Serve as the operational liaison with Procurement, Finance, IT, Compliance, and HRIS on topics including PO/invoice processing, vendor onboarding, system procurement, and more.
• Manage external TA vendors (e.g., agencies, background check providers, tech platforms), monitoring SLAs, cost efficiency, and performance outcomes.
• Lead quarterly business reviews with vendors and recommend renewals, replacements, or optimizations.
• Develop and maintain TA dashboards and scorecards measuring key KPIs (e.g., time-to-fill, offer acceptance, recruiter productivity).
• Ensure accuracy, consistency, and actionable insight in TA reporting to enable executive decision-making.
• Connect operational metrics with forecasting and strategic workforce insights.
• Lead or support global TA initiatives such as process harmonization, recruiter enablement programs, internal mobility enablement, or technology upgrades.
• Act as TA Operations lead on enterprise projects that intersect with HRIS, Finance, and Corporate Communications.

Requirements

• Bachelor’s degree required (preferably in Human Resources, Business Administration, or a related field).
• Minimum 6 years of Talent Acquisition or HR experience, including at least 2 years in TA operations, systems management, or project management.
• Proven experience managing ATS (preferably Greenhouse or Workday) and vendor relationships.
• Strong understanding of full-cycle recruitment processes, compliance standards, and data reporting practices.
• Strategic and detail-oriented with strong analytical and problem-solving abilities.
• Excellent stakeholder communication and cross-functional collaboration skills.
• Strong project management and documentation discipline.
• Ability to work effectively in a fast-paced, global, matrixed environment.
• High integrity, results orientation, and continuous-improvement mindset.

#Li-ML1

#Li-Hybrid

Legend Biotech is seeking a Senior Clinical Research Scientist as part of the Clinical Development team based in Somerset, NJ.

Role Overview

The Clinical Research Scientist (CS) in Clinical Development is an important role in the company supporting the development and life cycle of drug development projects. The Clinical Research Scientist will work closely with the Clinical Trial Lead/Medical Lead and Clinical Trial Manager to design and implement clinical trial protocols and manage sites, CROs and other associated work. In addition, the CS will support their manager to ensure program consistency & alignment across studies, working closely with cross-functional teams for achieving project goals, within timelines & with high quality. This clinical scientist will support early phase drug development in autoimmune indications.

Key Responsibilities

• Responsible to ensure the data review and cleaning activities meet the quality standards to support database locks in collaboration with data management and medical lead/clinical trial lead. Uses clinical and disease state knowledge to make recommendations for methods and strategy for data cleaning approach
• Collaborate with other functions to successfully support the planning and execution of clinical studies. Provides independent leadership of all areas requiring clinical input with oversight from the assigned Clinical Trial Lead/Medical Lead, and provides innovative and quality solutions for assigned problems and tasks.
• Provides clinical input and strategic recommendations for the planning and implementation of assigned clinical trial(s) including investigator selection, patient recruitment, feasibility questionnaire, training PowerPoints, and supporting Ethics committee submissions.
• Contributes to the strategic planning, preparation, and review of clinical documents (Protocol, ICFs, CSR, investigator brochure). May lead certain documents or sections of documents, including incorporation of input from other cross-functional team members.
• Provides clinical input and strategic recommendations for regulatory documents needed for all stages of assigned trial lifecycle (IND documentation, HA briefing books, BLAs, and Orphan Drug Applications).
• Responsible for clinical portions of key data management/statistical documents (eg: Case Report Forms, edit checks, data review plan and reports).
• Contribute to the planning and execution of external meetings and internal stakeholder meetings (e.g., Ad Boards, IMs, Governance, DMCs, Regulatory Authority, Dose Escalation meeting); responds to or triages questions for appropriate escalations. May have a speaking role on meetings when appropriate.
• Supports their manager when asked to contribute to harmonization between clinical trials and process improvement initiatives.
• May have the authority to make decisions related to issuing data cleaning queries and can decide whether there is a need to escalate for further discussion with the medical lead. They may also be delegated tasks from the clinical trial lead/medical lead for which they have decision making authority e.g. comment resolution when leading document creation.

Requirements

• At least a Bachelor’s degree in life science discipline.
• Bachelor’s degree with 4+ years’; or MS with 3+ years’; or PharmD/PhD with 2+ years of pharma experience in clinical development or related function.
• CAR-T cell therapy and/or autoimmune disease experience is a plus.
• Good interpersonal & communication skills, including oral, written and interpersonal.
• Ability to effectively manage conflicts and negotiations while providing impact and influence.
• Collaborative with the ability to operate across multiple geographies.
• Good leadership & organizational skills, analytical skills, and presentation skills.
• Creative problem-solving skills.
• Strong organizational and project management skill and the ability to multitask.
• Computer literacy required (MS word, MS excel, MS PowerPoint and MS Project).
• Oncology Therapeutic Experience preferred.
• Excellent working knowledge of GCP, FDA and ICH Guidelines.

#Li-JR1

#Li-Hybrid

Legend Biotech is seeking a Sr. Director, Clinical Operations Capabilities and Standards as part of the Clinical Operations team based in Somerset, NJ.

Role Overview

The Sr. Director, Clinical Operations Capabilities and Standards will be responsible for providing strategic leadership and oversight for foundational and centralized trial operations support towards cost-effective scalability of the Clinical Operations department. 

Among other responsibilities, this position will establish, oversee and grow Clinical Operations capability pillars that include Clinical Trial Planning and Analytics, Clinical Trial Operational Technologies, Vendor Alliance Management, Site Contracts & Payments, and Sample & Imaging Management Operations; including managing and developing staff within each pillar.

This position will also be the company subject-matter expert for clinical operations standards applied across the portfolio of Legend IND clinical trials.

Key Responsibilities

Oversee the development and strengthening of the following clinical operations capabilities and functions, with leads/teams in each of these areas:

Clinical Trial Planning & Analytics:

• Clinical Trial Planning and Analytics (CTP&A) is accountable for end‑to‑end clinical trial feasibility activities, supporting protocol optimization, country and site selection, enrollment forecasting, and risk mitigation across clinical programs.
• This function provides data‑driven feasibility insights to enable informed decision‑making during early study planning and partners closely with Clinical Operations Leads, Clinical Development, cross-functional stakeholders and external vendors to ensure trials are designed and placed for successful execution.
• This function is responsible for predictive trial performance modeling to enable proactive implementation of contingency plans

Clinical Trial Operational Technologies:

• The Clinical Trial Operations Technology function is responsible for the strategic ownership, governance, and optimization of clinical trial operations systems that enable compliant, efficient, and inspection‑ready execution of clinical trials.
• This function serves as the business owner for core clinical systems (e.g., CTMS, eTMF, and related platforms), ensuring alignment with clinical operations needs, regulatory requirements, and the company’s development portfolio. The position partners closely with Clinical Operations Leads, Quality, Regulatory, Data Management, IT, and CROs/external vendors.
• Areas of focus for capability building include leveraging technology to enable cost-efficient trial budget builds and ongoing costs optimization during study execution, enabling tools for targeted clinical operations risk management and technology-enabled eTMF oversight.

Vendor Alliance Management:

• Vendor Alliance Management is responsible for the strategic and operational oversight of external clinical operations vendors and CRO partners supporting clinical trials, including coordination of vendor due diligence for vendor qualification. Ensures vendors deliver high‑quality services in compliance with GxP and contractual expectations, while enabling efficient study execution across one or more clinical programs.
• Vendor Alliance Management is the primary interface between internal Clinical Operations Program Leads and external service providers, with accountability for vendor governance, performance management via objective metrics, issue escalation, and continuous improvement.

Site contracts and Payments

• Site Contracts & Payments is responsible for creating and overseeing a scalable and effective operating model for site contracting visibility, investigator payment operations, serving as a central point of accountability for improving operational control, process effectiveness, financial discipline, vendor performance consistency, and sponsor-CRO-site workflow alignment.

Sample and Imaging Management Operations

• Sample and Imaging Management is responsible for end-to-end sample and imaging oversight across Legend pipeline studies. To strengthen visibility, accountability, and coordination across sites, CROs, central labs, specialty labs, imaging vendors.
• Sample and Imaging Management focuses on system‑level consistency and risk reduction, mitigating against loss of patient data, enabling acceleration of data cleaning and reducing site burden for participation in clinical trials.
• Lead business owner for clinical operations standards and practices, including functional owner for clinical operational related SOPs and guidance documents.
• Performs other duties as required.

Key Relationships

• The Head of Clinical Operations Capabilities and Standards works closely with all applicable internal cross-functional leaders and teams as well as external vendors for the clinical operations capability building and strengthening.

Requirements

• Minimum degree requirements of a bachelor’s degree (BA, BS) in scientific or health care discipline. Advance Degree Preferred.
• 12+ years of progressive experience in pharmaceutical or biotechnology clinical operations, with demonstrated leadership responsibility across global clinical development programs.
• Significant experience in establishing, scaling, or transforming centralized Clinical Operations capabilities, including one or more of the following:
  • Clinical Trial Planning & Analytics / Feasibility
  • Clinical Trial Operational Technologies (e.g., CTMS, eTMF, analytics platforms)
  • Vendor Alliance Management
  • Site Contracts and Investigator Payments
  • Sample and Imaging Management Operations
• Proven expertise in end‑to‑end clinical trial conduct, including early‑phase through late‑phase trials, with strong understanding of protocol development, feasibility, start‑up, execution, and close‑out.
• Demonstrated strategic CRO and vendor oversight experience, including governance models, performance metrics, financial oversight, issue escalation, and continuous improvement.
• Experience acting as a functional or enterprise‑level clinical operations subject‑matter expert, defining standards, operating models, and best practices applied across multiple studies or programs.
• Strong background collaborating with Quality, Regulatory, Clinical Development, Data Management, Biostatistics, Medical Writing, Pharmacovigilance, Translational/Bioanalytical, Medical Affairs, Procurement, Legal and IT functions in a matrixed global environment.
• Experience participating in and/or supporting regulatory authority interactions (e.g., FDA inspections) related to clinical operations processes, vendors, systems, or trial conduct is strongly preferred.
• Demonstrated success leading, developing, and retaining high‑performing teams, including functional leaders.
• Willingness to travel as required (approximately 10%).
• Deep knowledge of clinical trial operations frameworks, including industry best practices and regulatory expectations (ICH‑GCP, FDA, and global health authorities).
• Strong capability in clinical operations operating model design, including centralization, standardization, governance, and scalability.
• Demonstrated leadership in clinical operations technology enablement, including business ownership of systems (e.g., CTMS, eTMF), data quality oversight, technology‑enabled risk management, and inspection readiness.
• Expertise in vendor and alliance management, including development of governance structures, KPI frameworks, financial oversight, and performance optimization.
• Understanding of clinical trial sample, imaging, and data flows, with ability to design operational controls that reduce patient data risk, site burden, and cycle times.
• Ability to translate portfolio‑level strategy into executable clinical operations capabilities, standards, and guidance.
• Proven strategic and critical thinking skills, with a data‑driven mindset and ability to anticipate operational risks and mitigation strategies.
• Strong experience developing, authoring, and governing clinical operations SOPs, standards, and guidance documents.
• Exceptional communication, presentation, and stakeholder influence skills, with the ability to engage senior leadership and cross‑functional teams.
• High proficiency with clinical operations–relevant technologies and tools, including MS Office (Excel, PowerPoint, Word) and enterprise clinical systems; ability to leverage analytics for operational decision‑making.

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Legend Biotech is seeking a Preclinical Scientist as part of the Research and Early Development team based in Somerset, NJ.

Role Overview

This position will perform preclinical IND-enabling pharmacology and toxicology studies to support pipeline programs. The ideal candidate will have experience in immunology or immune-oncology to assist preclinical cell therapy studies from discovery to first-in-human trials, and through marketing authorization. Furthermore, the successful candidate will work in a collaborative environment , and would be skillful in driving multiple projects by contributing to the development of cell-based immunotherapies.

Key Responsibilities

• Develop and validate assays to support diverse projects from lead optimization to the conduct of preclinical pharmacology and toxicology studies for regulatory submission. This includes, designing, optimizing, and implementing IND-enabling studies, contributing to the creation, review, and approval of prospective standard operating procedures, executing in vitro and in vivo IND-enabling studies, recording all experiments in an electronic laboratory notebook, reporting any deviations, analyzing and reporting processed data in the form of a study report.
• Design and support in vitro IND-enabling studies to assess efficacy and safety of cell therapies. 
• Support the preparation of scientific and regulatory documents of IND-enabling preclinical studies.
• The Preclinical Scientist will work independently reporting directly to the Director of Preclinical Pharmacology and Toxicology.
• The Preclinical Scientist will demonstrate competency and professionalism especially as it pertains to using the scientific method to design, execute, and troubleshoot in vitro laboratory experiments.

Requirements

• BS plus 5 years of experience, MS plus 3 years of experience.
• Work experience in immunology, cancer biology or related fields.
  
• Knowledge and expertise in immune-oncology of large molecules or cell therapy is a plus.
  
• Strong scientific background with hands on experience in cellular and molecular biology techniques (e.g., flow cytometry, ELISA, cell culture and cytotoxicity assays, qPCR, Western Blot and others).
  
• Demonstrated track record of scientific contributions in peer-reviewed journals and symposia.
  
• Ability to manage multiple programs in parallel while delivering on key milestones.
  
• Knowledge of GLP and regulatory agencies is a plus.
  
• Ability to multi-task in a fast-paced, highly collaborative diverse team environment.

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Legend Biotech is seeking a Capability Manager, Business Applications as part of the IT team based in Somerset, NJ.

Role Overview

The IT Manager – Business Applications is a technically strong individual contributor responsible for partnering with business functions and enabling the successful delivery, enhancement, and support of enterprise applications across corporate domains including Finance, Procurement, Commercial, and other business functions as needed.
Reporting to the Lead, Business Applications, this role owns end-to-end system capabilities including configuration, integration, support, and continuous improvement. The role bridges technical execution with strategic planning, driving project delivery in collaboration with cross-functional stakeholders including business teams, enterprise architecture, cybersecurity, vendors, and auditors.
The ideal candidate brings deep technical expertise, strong business partnership skills, and a forward-looking mindset toward innovation, scalability, compliance, and lifecycle management across a diverse application landscape.

Key Responsibilities

• Serve as the IT business enablement lead for Business Applications spanning Finance, Procurement, Commercial, and other corporate functions, leveraging platforms such as SAP S/4HANA, SAP BTP, SAP Ariba, Anaplan, and other enterprise or SaaS solutions.
• Lead configuration, administration, and continuous improvement of applications with a focus on scalability, integration, automation, and user experience.
• Partner with business stakeholders to understand requirements and translate them into robust, scalable, and compliant technology solutions.
• Design, implement, and maintain secure integrations between enterprise systems and internal/external applications, ensuring data integrity and seamless process flow.
• Provide advanced Tier 2/3 application support, coordinating with managed service providers and vendors to ensure SLA adherence and continuous service improvement.
• Lead testing strategies including system integration testing, UAT, regression testing, and release/cutover planning for system upgrades and enhancements.
• Monitor system performance, availability, and data quality; proactively identify and drive improvements, optimization opportunities, and technical debt reduction.
• Support compliance and audit activities (SOX, GxP, and other regulatory requirements), ensuring proper documentation, controls, and audit readiness.
• Maintain comprehensive system documentation, knowledge articles, and user guides to support adoption and operational excellence.
  Provide regular updates on project delivery, system health, and enhancement roadmaps to IT and business stakeholders.
• Stay current with industry trends across Finance, Procurement, and Commercial technology landscapes, identifying opportunities for innovation and value creation.
• Act as a trusted advisor to IT and business leaders on system capabilities, risks, vendor performance, and transformation initiatives.

Requirements

• Bachelor’s degree in computer science, Information Systems, Finance or related field, or equivalent combination of education and experience.
• Relevant certifications such as SAP S/4HANA, SAP BTP, or Anaplan are preferred.
• PMP, Agile, or equivalent project management certifications are a plus.
• 10+ years of progressive experience in business application delivery, development, support.
• Experience supporting business functions such as Finance, Procurement, and/or Commercial systems
• Experience in Anaplan Project Implementations is strongly preferred.
• Strong hands-on experience with one or more platforms such as SAP S/4HANA, SAP BTP, SAP Ariba, Anaplan, or similar enterprise applications.
• Working knowledge of system integration methods (e.g., APIs, SFTP, middleware) and tools.
• Understanding Finance processes such as Finance Planning, Management & External Reporting, Capex Planning, Monthly Close Process, Reporting and Data Analytics.
• Experience with system compliance activities including SOX, GxP, and audit-readiness.
• Experience working with SaaS vendors and managing issue resolution through ticketing systems.
• Ability to operate effectively in a matrixed, cross-functional environment.
• Strong analytical, problem-solving, and troubleshooting capabilities.
• Customer-focused mindset with strong stakeholder engagement skills.
• Excellent communication and collaboration skills across technical and business audiences.
• Ability to manage multiple priorities in a fast-paced environment.
• Strong attention to detail and commitment to high-quality deliverables.
• Knowledge of ITIL processes, incident, and change management practices preferred.
• Proactive mindset with a focus on continuous improvement and innovation.

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Legend Biotech is seeking an Executive Director, Pipeline Clinical Lead as part of the Clinical Development team based in Somerset, NJ.

Role Overview

The Pipeline Clinical Lead is a senior clinical development leader accountable for the scientific and medical direction of early stage clinical programs. This role provides strategic and operational leadership across first in human through proof of concept studies, with accountability for clinical strategy, trial design, execution, interpretation, and regulatory interactions.

The Pipeline Clinical Lead will lead and develop a team of physicians and scientists, work closely with cross functional partners, and collaborate with external development partners and investigators. Deep expertise in clinical trial design, regulatory frameworks, and compliance in drug development—ideally within cell therapy—is essential.

This role requires strong scientific judgment, leadership presence, and a hands on approach in a fast paced, entrepreneurial environment, with a clear focus on patient safety and clinical impact.

Key Responsibilities

Clinical Development Leadership

• Serve as clinical science lead for early stage programs (pre IND through Phase 1/2), including study design, execution, data interpretation, and reporting.
• Define and integrate clinical strategies, including PK/PD, biomarkers, diagnostics, and translational approaches, particularly for cell and gene therapies.
• Provide clinical input into asset selection, review of preclinical data, and development path decisions.

Regulatory & Compliance

• Lead or support IND preparation and amendments, clinical sections of regulatory submissions, and responses to health authority questions.
• Represent the clinical function in pre IND, IND, and (as applicable) BLA/MAA interactions with regulatory agencies.
• Champion patient safety, ethical conduct, and compliance with GCP, corporate policies, and global healthcare regulations.

Cross Functional & External Collaboration

• Partner closely with Clinical Operations, Biostatistics, Regulatory Affairs, Early Discovery,
• Manufacturing, Biomarkers, and Pharmacovigilance to ensure integrated program delivery.
• Collaborate with external development partners, academic investigators, KOLs, and study sites.
• Act as a credible scientific and clinical representative for programs in internal governance and external forums.

People & Matrix Leadership

• Provide direct line management and mentorship for Medical Directors, Clinical Research Scientists, Medical Writing, Clinical Program management and other clinical staff as applicable.
• Lead effectively in a matrix environment, anticipating cross functional needs and proactively resolving conflicts or risks.
• Contribute clinical leadership to business development, due diligence, and partnership activities when required.

Requirements

• MD or MD PhD (or equivalent) with US board certification or international equivalent.
• ≥8 years of clinical development experience in industry and/or academia, with demonstrated leadership in hematology/oncology.
• Proven experience designing and executing clinical trials from first in human through registrational stages.
• Prior involvement with IND submissions; experience with BLA/MAA filings and health authority meetings strongly preferred.
• Cell therapy and/or CAR T clinical development experience highly desirable IT Skills.
• Strong scientific judgment with the ability to navigate complex clinical and regulatory challenges.
• Demonstrated ability to lead cross functional and geographically distributed teams in a matrix environment.
• Excellent written and oral communication skills, including protocol writing, regulatory documents, publications, and senior level presentations.
• Highly collaborative, influential leader with the ability to represent programs with credibility and confidence.
• Hands on, execution oriented mindset with strong organizational and analytical skills.
• Willingness to travel up to 15–20%.

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Legend Biotech is seeking a Sr. Medical Director/Executive Director, Early Clinical Development as part of the Clinical Development team based in Somerset, NJ.

Role Overview

The Sr. Medical Director/Executive Director of Early Clinical Development is a critical role in the company with significant impact on the development and life cycle of drug development projects. The candidate for this role will be responsible to lead the Early Clinical Development Team, for IND submission and the design, execution and oversight of first-in-human, dose finding clinical trials. Full understanding of tenets of FIH studies (e.g. dose selection rationale, biomarker plans, etc.) and the relevant compliance framework for clinical development activities are essential. Candidate must possess passion for science and patients, as well as entrepreneurial drive to help the organization succeed.

Key Responsibilities

• Lead clinical science aspects of design, execution, interpretation and reporting of early (first in human) stage clinical trials.
• Collaborate with scientists and technical experts to integrate cellular therapy specific aspects of PK/PD, diagnostic, and biomarker plans into the overall clinical development strategy.
• Contribute clinical leadership and expertise in the development of study protocols and clinical study reports, study medical monitoring, safety reporting, regulatory documentation and interactions, and other clinical deliverables.
• Collaborate with academic scientists, clinical experts, and study investigators.
• Represent and advocate for the project in internal and external venues.
• Clinical leadership for business development and partnership activities as needed.
• Act as a champion for high standards of compliance, ethics and safety, and putting patients first.

Requirements

• MD or MD-PhD or equivalent medical degree with US board certification in hematology and/or oncology.
• 3+ (Senior) / 6+ (Executive) years’ industry/ academic clinical development experience in hematology/oncology, leading cross-functional development teams is required.
• Sub-specialization and/or clinical development experience in cell therapies or CAR-T is highly desirable.
• Experience in biotech - preferred but not required.
• Demonstrated capacity to think creatively when addressing complex situations
• Demonstrated excellence and experience in first-in-human clinical development including the design, execution of first in human trial, and submission of INDs.
• Experience leading pre-IND and IND meetings with health authorities is highly desirable.
• Excellent communication and leadership skills; willingness to “roll up the sleeves” to contribute to team efforts in a dynamic, fast-paced environment; stellar writing skills, a track record of publications; superb presentation skills
• Able to anticipate biometrics, regulatory, clinical operations, development sciences, pharmacovigilance, and other development needs to ensure successful program delivery
• Ability to communicate effectively with cross functional teams such as pre-clinical scientists, clinical operations, safety-PV, biomarker, biostatistics, regulatory, and project management including peer to peer interactions with academic scientific experts, KOLs and stake holders.
• Assure that the highest quality, ethical & professional values are demonstrated in all aspects of the team work
• Ensures compliance with corporate policies and procedures, as well as, all related healthcare laws and regulations
• Highly collaborative & effective influencing skills and the ability to operate across multiple geographies
• Strong track record of delivering results through effective team and peer leadership in matrix
• Superior interpersonal skills, & communication skills ensuring full alignment of cross functional teams. Ability to effectively manage conflicts and negotiations while providing impact and influence. Communicate regularly and effectively with senior leaders.
• Excellent leadership & organizational skills, analytical skills, presentation skills, and strong experience in translating medical/clinical information into clinical development strategies.
• Travel requirement up to 15-20 % of the time.

The advertised pay range covers both levels of this position.

Here's the base pay range by level:

Sr. Medical Director, Early Clinical Development- $294,483 - $386,511

Executive Medical Director, Early Clinical Development- $338,656- $444,486

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Legend Biotech is seeking a Manager, Sample Management Operations as part of the Clinical Operations team based in Somerset, NJ.

Role Overview

The Sample Management Operations Manager is responsible for overseeing end-to-end sample management across Legend pipeline studies. The role strengthens visibility, accountability, and coordination across sites, CROs, central labs and specialty labs.

Key Responsibilities

• Manage the operating model for sample management across current and future studies.
  
• Map and standardize workflows across sites, CROs, central labs, specialty labs, the sample management vendor, and sponsor stakeholders.
  
• Create visibility into critical handoffs, chain of custody, issue resolution, reconciliation activities, and operational dependencies.
  
• Monitor operation trends and proactively identify operational risks and mitigation plans that reduce delayed, lost, or poorly coordinated samples.
  
• Serve as lead for sample tracking and oversight capabilities enabled through the sample management vendor.
  
• Work with study teams and external vendors to reduce delays, missing data, and operational burden at sites.
  
• Support readiness for inspections, audits, and quality reviews related to sample operations.
  
• Create playbooks, templates, and role clarity to support consistent execution across studies.
  
• Capture lessons learned and apply them to future study planning and execution.
  
• Performs other duties as required.
• Works closely with Sr. Director of Clinical Operations and collaborates with Clinical Operations, Data Management, QA, ITQA, central labs, specialty labs, CROs, sites, and other cross-functional stakeholders.

Requirements

• Minimum degree requirements of a bachelor’s degree (BA, BS) in scientific, health care, or related discipline. Advanced degree preferred.
• 7+ years of pharmaceutical, biotech, CRO, or related clinical research experience.
  
• Experience in clinical operations with exposure to sample management, lab operations, or related oversight functions required.
  
• Experience developing or improving complex operational workflows strongly preferred.
  
• Experience with central labs, specialty labs or sample tracking solutions preferred.
  
• Oncology, cell therapy, or early-phase clinical development experience preferred.
  
• Ability to travel as necessary (up to 10%).
• Effective oral, written, and interpersonal communication skills.
• Strong organizational, project management, and issue resolution skills.
  
• Ability to identify operational risk and develop practical mitigation strategies.
  
• Strong attention to detail while maintaining end-to-end process visibility.
  
• Computer literacy required (MS Word, MS Excel, MS PowerPoint, MS Project and applicable operational tools).
  
• Working knowledge of GCP, FDA, and ICH Guidelines.

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