Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Vice President, Medical Affairs Oncology is a member of the Development Leadership Team reporting to the Chief Medical Officer. This senior executive leader is accountable for the end-to-end design and execution of the Medical Affairs strategy across Parabilis portfolio, including Scientific Communications, Medical Education, Evidence Generation, Key Opinion Leader (KOL) Engagement, Publication Planning, and Medical Information. This role ensures scientific excellence and cross-functional integration across all development programs and builds a scalable Medical Affairs organization capable of supporting global, multi-indication growth.

Key Responsibilities:

Strategic Leadership

• Define and execute the Medical Affairs Oncology strategy aligned with the clinical development roadmap and portfolio priorities.
• Serve as a core member of the Development Leadership Team and contribute to broader
• Development governance and portfolio decision-making.
• Support portfolio-level medical prioritization, lifecycle planning, and cross-indication strategy.

KOL Engagement & Medical Education

• Build and sustain relationships with leading KOLs, academic medical centers, and cooperative groups relevant to Parabilis’ pipeline.
• Design and oversee Medical Education programs that advance understanding of Parabilis’ science, novel mechanisms, and unmet need across tumor types.

Evidence Generation & Publication Strategy

• Lead the development and execution of a robust evidence generation strategy, including investigator-initiated studies, real-world evidence, and health outcomes research
• Oversee development and execution of a comprehensive publication plan aligned with clinical milestones and regulatory timelines
• Build global medical affairs infrastructure to support multi-program, multi-regional growth
• Drive Medical Affairs KPIs and impact metrics in support of portfolio strategy and commercial readiness

Scientific Communications & Medical Information

• Lead scientific communications strategy to accurately and compellingly convey the differentiated profile of Parabilis’ Helicon™ platform and pipeline assets
• Oversee Medical Information function, ensuring timely, accurate, and compliant responses to healthcare professional inquiries
• Oversee the creation of high-quality medical education materials, slide decks, and scientific exchange resources
• Establish scalable medical affairs infrastructure to support launch readiness across tumor types and geographies

Patient Advocacy and Patient Support

• Building trusted partnerships with advocacy organizations across Parabilis' specific tumor types
• Integrating the patient voice into MA strategy, trial design, and evidence generation
• Collaborating with patient communities on disease awareness and education
• Developing patient support programs to improve access, adherence, and trial participation ensuring all patients’ engagement is conducted with ethical rigor and full compliance

Cross-functional Partnership & Commercial Readiness

• Partner closely with Clinical Development, Regulatory Affairs, and New Product Planning to ensure scientific and medical alignment across the development and pre-commercialization continuum
• Support payer strategies by contributing to value dossiers, HEOR data packages

Compliance & Medical Governance

• Lead development and continuous improvement of Medical Affairs SOPs, governance frameworks, and compliance systems
• Ensure all Medical Affairs activities are executed in accordance with applicable regulations, industry codes, and Parabilis’ internal policies

Organizational Leadership

• Build and mentor a high-performing Medical Affairs Oncology team with deep scientific expertise and strong cross-functional collaboration skills
• Establish clear accountability, performance metrics, and a culture of scientific rigor and integrity
• Foster a culture of collaboration, scientific curiosity, and patient-centricity across the Medical Affairs team

What you’ll need to be successful:

• MD required; PharmD or PhD in a relevant biomedical discipline may be considered with commensurate experience
• 15+ years of progressive biopharmaceutical industry experience, with a minimum of 8 years in Medical Affairs with deep scientific expertise in oncology
• Demonstrated success building and leading Medical Affairs organizations, including KOL engagement, evidence generation, and scientific communications
• Experience standing up Medical Affairs capabilities in high-growth, clinical-stage biotech or pharmaceutical environments
• Strong scientific credibility, executive leadership presence, and ability to engage effectively with both internal and external stakeholders
• High emotional intelligence and track record of cross-functional influence across Development, Commercial, and Regulatory functions

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $360,000-$410,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

About Graphcore

At Graphcore, we’re building the future of AI compute.We’re a team of semiconductor, software and AI experts, with deep experience in creating the complete AI compute stack - from silicon and software to infrastructure at datacenter scale.As part of the SoftBank Group, backed by significant long-term investment, we are delivering key technology into the fast-growing SoftBank AI ecosystem.To meet the vast and exciting AI opportunity, Graphcore is expanding its teams around the world.We are bringing together the brightest minds to solve the toughest problems, in a place where everyone has the opportunity to make an impact on the company, our products and the future of artificial intelligence.

Job Summary

As a researcher at Graphcore, you will contribute to the advancement of AI research, investigating new ideas that push the limits on important AI/ML problems. Specialised hardware has been the key driver of the progress of AI over the last decade, and we believe that hardware-aware AI algorithms and AI-aware hardware developments will continue to be critical to advancing this exciting field. As such, we’re looking for candidates who are keen scientists and engineers, with the theoretical and practical skills needed for impactful AI research.

We are looking for researchers with experience of AI in low-power, edge and embodied scenarios such as robotics, autonomous driving and augmented/virtual reality. We are interested in the training and deployment of multimodal AI models in these contexts, covering areas such as world models, real-time computer vision, generating and reasoning over audio/video streams.

The Team

Graphcore Research participates in both fundamental and applied research, to characterise the computational requirements of machine intelligence and to demonstrate how hardware can drive the next generation of innovative AI models. We publish at leading AI/ML conferences (NeurIPS, ICML, ICLR) as well as specialist workshops, and collaborate with other research teams and organisations across the world.

We pride ourselves on being a supportive and collaborative team, where we organise around our individual research interests to solve problems together in domains such as efficient compute, model scaling and distributed training and inference of AI models for multiple modalities and applications, including for sequence- and graph-based data. We’re based across London, Cambridge and Bristol, with projects and discussions that involve all our locations.

Perhaps the best way to get an idea of what we’re all about is to read one of our papers or an article on our blog. If you’re excited to work at the cutting edge of AI supported by new hardware and want to develop your skills in this area, we’d love to hear from you!

Responsibilities and Duties

• Generate AI/ML ideas, design experiments, implement them & evaluate results.
• Prepare, submit & present your work to AI conferences and workshops.
• Collaborate with researchers, silicon and software engineers at Graphcore to help define, build and test Graphcore’s next generation of AI hardware.

About you:

Essential:

• Master’s, PhD or equivalent experience in a technical discipline (e.g., Maths, Statistics, Computer Science, Physics, Chemistry, Biomedical Engineering).
• Experience in embodied AI, world models or robotics.
• Python programming in a modern deep learning framework, e.g. PyTorch or JAX.
• Familiar with deep learning fundamentals: models, optimisation, evaluation and scaling.
• Capable of designing, executing and reporting from ML experiments.
• Mathematics skills to support the above: calculus, probability theory and linear algebra.
• Experience submitting papers to international scientific conferences or workshops.

Desirable:

• Lower-level programming for hardware efficiency, e.g. C++/CUDA/Triton.
• Practical familiarity with hardware capabilities for deep learning – threads, caches, vector & matrix engines, data dependencies, bus widths and throttling.
• Practical familiarity with software stacks for deep learning – compilation, kernel fusion, XLA/ATen ops, streams, and asynchronous execution.
• Conference or workshop submissions in the fields of embodied AI, world models, or robotics.

Benefits

In addition to a competitive salary, Graphcore offers flexible working, a generous annual leave policy, private medical insurance and health cash plan, a dental plan, pension (matched up to 5%), life assurance and income protection. We have a generous parental leave policy and an employee assistance programme (which includes health, mental wellbeing, and bereavement support). We offer a range of healthy food and snacks at our central Bristol office and have our own barista bar! We welcome people of different backgrounds and experiences; we’re committed to building an inclusive work environment that makes Graphcore a great home for everyone. We offer an equal opportunity process and understand that there are visible and invisible differences in all of us. We can provide a flexible approach to interview and encourage you to chat to us if you require any reasonable adjustments.

Applicants for this position must hold the right to work in the UK. Unfortunately at this time, we are unable to provide visa sponsorship or support for visa applications

About Every Cure:   

Every Cure is an AI-driven nonprofit, biotech organization on a mission to save and improve lives by repurposing existing medicines for diseases with significant unmet need. We are working to create a world where every drug is used to treat every disease it possibly can, so that no patient suffers when an existing treatment could help them. We are filling a gap left by the current biomedical system, which doesn’t systematically pursue new uses for old drugs. Through artificial intelligence technologies, collaboration with healthcare professionals, and patient advocacy, Every Cure is dedicated to unlocking the full potential of existing medicines to treat every disease and every patient we possibly can. Inspired by Every Cure’s co-founders' work repurposing drugs for Castleman disease and other rare diseases, Every Cure is advancing repurposed treatments for neglected diseases and has been featured in The New Yorker,  New York Times, USA Today, Good Morning America and other news media. Led by a talented leadership team and an outstanding Board of Directors, Every Cure is supported through funding from leading philanthropic organizations like Chan Zuckerberg Initiative, TED’s Audacious Project, and ARPA-H. 

 Our approach:  

• AI-Powered Identification: We use advanced artificial intelligence to analyze the world’s biomedical knowledge and identify FDA-approved drugs that can be repurposed for untreated conditions. This cutting-edge technology enables us to explore new therapeutic possibilities efficiently.  
• Open-Source Commitment: We are dedicated to making our predictive pipeline open-source, fostering collaboration and transparency within the scientific community and unlocking the potential for discovering new treatments.  
• High-Impact Focus: We prioritize drug repurposing opportunities that will relieve the most suffering and have the greatest impact possible.  
• Rigorous Validation: Promising opportunities are thoroughly validated through laboratory and clinical studies to confirm their efficacy and safety before advancing to broader application.  
• Strategic Marketing and Access: We disseminate information about effective repurposed treatments through multiple channels and are committed to ensuring that new cures are accessible to all patients.

Applicants must reside in the state specified at the top of this job posting. Residency in that state is a requirement for consideration and must be maintained for the duration of employment.

The Head of Clinical Development leads Every Cure’s clinical research and development function, serving as both strategic architect and working clinical lead on priority programs. They manage a diverse portfolio of drug repurposing initiatives including Every Cure-sponsored interventional trials (with full sponsor IND accountability and REMS complexity where applicable), collaborative investigator-sponsored trials, and Every Cure-led patient registries, natural history studies, and other real-world studies. They collaborate directly with computational and data science teams to translate AI-driven repurposing hypotheses into clinically testable programs and represent the organization to external partners and stakeholders. This role owns sponsor compliance under ICH E6(R3) including maintenance of the clinical QMS and SOP infrastructure regardless of CRO engagement  and oversees regulatory strategy and dissemination. The HCD supports Every Cure’s CSO and engages directly with external stakeholders including CROs, clinical trial technology vendors, academic investigators, patient advocacy organizations, the IRB of record, and FDA. The HCD helps build and lead a lean internal clinical development team, modeling the working-leader norm expected in a small, mission-driven organization.

How you will make an impact: 

Strategic Leadership of Clinical Development and Medical Affairs

• Set the direction for Every Cure’s clinical research and development, ensuring alignment with the organization’s mission to repurpose FDA-approved drugs for high-impact unmet needs, while personally leading or co-leading priority programs.
• Lead the execution of organizational goals through operational planning and cross-functional integration, personally owning project timelines, quality standards, and accountability metrics for priority programs rather than delegating all execution.
• Provide expert counsel to the CSO, President and Scientific Advisory Council on medical strategy, program development, and organizational growth.

Research and Clinical Development Oversight

• Design, author, and review key study documents (protocols, statistical analysis plans, informed consent documents, clinical study reports, investigator brochures) for Every Cure-sponsored clinical trials, patient registries, natural history studies, and real-world evidence assessments. Own study design decisions end-to-end, from scientific rationale through data integrity and analysis.
• Serve as sponsor medical lead and/or medical monitor on Every Cure-sponsored IND-holding studies (delegating per-study where appropriate), ensuring all research activities are ethically sound, methodologically rigorous, and regulatory compliant under FDA 21 CFR Part 312, ICH E6(R3), and ICH E9 principles.
• Translate complex medical findings into strategic decisions regarding program continuation, optimization, or sunsetting, based on efficacy, feasibility, and patient impact.
• Responsible for compliance and oversight of the Human Subjects Research program at Every Cure, including IRB (Advarra) submissions and amendments, sponsor safety reporting (IND safety reports, DSURs), SAE adjudication, signal detection, and REMS program participation where applicable (e.g., lenalidomide).

Portfolio Strategy and Program Management

• Partner on strategic prioritization and dynamic management of Every Cure’s diverse portfolio of drug repurposing opportunities, applying a risk-adjusted, impact-oriented lens to maximize outcomes.
• Direct the progression of programs through clinical and dissemination stages, using insights from AI models and external scientific inputs. Personally lead CRO and clinical technology vendor selection, contracting input, and ongoing governance (joint steering committees, KPIs, oversight plans) for highest-priority programs.
• Develop and manage resource allocation frameworks across disease areas and therapeutic modalities, ensuring optimal investment of time, talent, and funding toward the most promising interventions.

Leadership and Team Development

• Build, mentor, and lead a lean, high-performing team of clinical research and medical professionals united around a shared vision of maximizing patient impact through drug repurposing, modeling a working-leader norm in which senior leaders contribute directly alongside their teams.
• Define roles, responsibilities, and performance standards for the clinical team while fostering a culture of excellence, integrity, psychological safety, and cross-functional collaboration.
• Promote continuous learning and growth through coaching, training programs, and development opportunities that build both individual capability and team effectiveness.

Stakeholder Engagement, Compliance, and Dissemination

• Act as medical spokesperson and lead regulatory interface for Every Cure in public, scientific, and regulatory forums (including FDA pre-IND and Type B/C meetings), promoting the organization’s mission and sharing results from preclinical and clinical programs.
• Cultivate and manage partnerships with CROs, patient advocacy groups, academic institutions, and regulatory agencies to ensure successful execution and wide-scale impact of therapeutic programs.
• Guide the regulatory approval and post-study dissemination strategies to ensure timely and effective translation of research into therapies accessible to patients, including peer-reviewed publications, policy briefs, and healthcare provider outreach.
• Partner with the Impact lead to provide input and perspective on dissemination and to engage with key stakeholders to ensure medicines reach patients.

What you bring to the team:

Education 

• MD or MD/PhD preferred; PhD DO, or PharmD acceptable

Work Experience (Two-Tier: Head of / VP)

• Minimum for Head of Clinical Development: 8+ years of clinical development experience post-MD (or equivalent), including service as clinical lead on at least one sponsor-held Phase 2 trial from protocol through database lock.
• Demonstrated leadership experience recruiting, mentoring, and managing cross-functional clinical teams, with explicit willingness and proven ability to work hands-on alongside direct reports in a small-organization setting.
• Expertise in drug development, clinical trial design (including interventional trials in rare or ultra-rare populations), and clinical decision-making.
• Sponsor-side experience running Phase 2 trials (distinct from CRO or academic investigator experience).
• Experience working across more than one therapeutic research area.
• Experience with small-sample trial designs and natural history or registry data.
• Proven leadership in driving strategic initiatives and cross-functional collaboration to advance scientific and organizational goals.

Preferred for Vice President designation:

• 12+ years of clinical development experience, including prior functional leadership at a sponsor (Executive Director, Head of, or VP level); multiple sponsor-held INDs led through Phase 2 or beyond; direct experience with REMS programs, risk-based monitoring, or similarly complex regulatory programs; and prior responsibility for building or scaling a clinical QMS under ICH E6(R3) or predecessor standards.

Skills 

• Proficiency in clinical research, real-world evidence assessments, evidence generation, patient registry design, clinical trial execution, and sponsor-side pharmacovigilance.
• Working knowledge of FDA IND regulations (21 CFR Part 312), ICH E6(R3) Good Clinical Practice, ICH E9 statistical principles, 21 CFR Part 11 for electronic records, and REMS program requirements; familiarity with EU CTR a plus.
• Exceptional communication and presentation abilities.
• Demonstrated ability to foster and sustain a collaborative, cross-functional culture grounded in shared organizational mission and values.
• Able to partner effectively with computational and data science teams and critically evaluate AI/ML-driven repurposing hypotheses for clinical translatability.
• Strategic thinker with a focus on urgency, efficiency, and impact.
• Passionate about Every Cure’s mission and values.
• Highly adaptable, thriving in a fast-paced, start-up environment.
• Explicit willingness to be hands-on: comfort authoring and reviewing key clinical documents (protocols, SOPs, CSRs), directly managing vendor/CRO relationships, and working alongside junior staff rather than exclusively through delegation. Candidates seeking a purely oversight or figurehead role are not a fit for this position.

Compensations & Benefits: 

• Your paycheck: Competitive salary based on experience, ranging from $250,000 - $275,000 annually. 
• Health and wellness: Comprehensive plans with medical, dental, and vision coverage, plus a Flexible Spending Account (FSA) for eligible healthcare expenses. 
• Future nest egg: A 403(b)-retirement plan with an employer match of 3.5% helps you save for your future. 
• Relax and recharge: Generous time off, including paid time off and paid holidays. 
• We have you covered: Comprehensive paid leave for family and medical needs, ensuring you have the support you need during important times. 

This role is based in Cambridge, MA, with an expectation of minimum 3 days per week in office.  

Every Cure is an Equal Opportunity Employer. We celebrate diversity and are committed to creating an inclusive environment for all employees. We provide equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, genetics, or any other characteristic protected by federal, state, or local laws.

Your Impact at LILA

Lila Sciences is seeking a relentless executor and strategic operator to spearhead our Instrument Development initiatives and lead our Virtual Lab Team. As the Director of Instrument Development Acceleration, you will be responsible for getting instruments online, fast, reliably, and at scale. The role is for someone who thrives in high-throughput environments and measures success in instruments shipped.

What You'll Be Building

• Set clear expectations, remove obstacles quickly, and keep the team focused on delivery over deliberation.
• Own the rapid design and development of laboratory instruments across the full lifecycle, from concept to operational in the lab, at high volume.
• Architect and implement integration frameworks connecting virtual laboratory environments with physical instrumentation and robotic systems.
• Maintain rigorous hardware-software integration standards, system performance benchmarks, and quality assurance processes without letting them become bottlenecks.
• Make pragmatic technical decisions across software, hardware, and systems integration that keep momentum, escalating only what truly needs escalation.
• Work tightly with AI researchers, software engineers, and robotics teams to drive fast, efficient system integration and deployment.
• Communicate clearly and concisely on status, blockers, and decisions to stakeholders at all levels.
• Build and refine lean development practices that prioritize speed, system reliability, and repeatable quality assurance.

What You’ll Need to Succeed

• Bachelor's or Master's degree in Computer Science, Engineering, Biomedical Engineering, or a related field. Ph.D. is a plus but not required.
• At least 10 years in engineering or technical leadership, with a proven record of delivering complex systems at scale and on time.
• Strong hands-on coding ability in C++, Python, or Java, with deep experience in hardware-software integration.
• Proven ability to lead complex systems integration across software, hardware, and robotic platforms.
• A problem-solver who makes decisions with imperfect information and keeps moving.
• Clear, direct communicator who can align engineers and stakeholders without unnecessary overhead.

Bonus Points For

• Experience with agile or lean development methodologies in high-throughput environments.
• Hands-on knowledge of AI, robotics, and simulation technologies as applied to laboratory instrumentation and automation.
• Experience with system monitoring, performance optimization, and QA in hardware-software environments.
• Track record of scaling teams and processes during periods of rapid growth.

Your Impact at LILA

Role will lead development and validation of novel mammalian cell based pooled assays. The role will span proof of concept to automated screens to generate highly multiplexed and high dimensional datasets. The role will partner across cell biology, protein design and nucleic acid teams to support biologic development programs with the rapid determination of binding, stability, function, and immunogenicity of a variety of biologics.

What You'll Be Building

• Build next-generation mammalian display based binding, stability, function, and immunogenicity assays.
• Implement state-of-the art multiomic, single cell and in situ sequencing workflows to create novel highly multiplexed assays.
• Partner with protein design, nucleic acid, protein and automation teams to apply these workflows to the development of biologics.
• Closed-Loop Experimentation and Execution: partner closely with engineering and automation to design and exercise platforms for automated, high-throughput experimentation and data-rich workflows. Collaborate with AI team to run iterative experiments in real time, enabling fast optimization and discovery cycles.
• Collaborate, Lead & communicate: Work with cell biologists, synthetic biologists, automation engineers, protein design scientists and data scientists to document systems, share insights, and refine best practices in autonomous science. Mentor junior scientists, align milestones with internal/external collaborators, contribute to IP and publications, and present findings across the org.

What You’ll Need to Succeed

• Ph.D. in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, Immunology, or related field (or M.S./B.S. with 5–8+ years relevant industry experience).
• Expertise with the development and/or application of mammalian display or similar pooled mammalian (perturb-seq, MPRA, etc.) systems
• Expertise with designing, executing and analyzing single cell, in situ or multiomic sequencing based experiments
• Experience designing novel single cell, in situ or multiomic sequencing based techniques
• Experience designing, executing and analyzing flow cytometry and sorting based experiments
• Experience creating highly complex libraries of defined sequences in mammalian cells
• Experience designing, executing and analyzing NGS based experiments

Bonus Points For

• Experience with antibody or cell therapy development
• Imaging experience
• Experience with optical pooled screening or image-based cell sorting
• Experience with encapsulation/droplet/bead/microwell based antibody or cell screening

Your Impact at LILA

We are seeking a (Senior) Research Associate to join our Life Sciences team. This role will focus on formulating lipid nanoparticles (LNPs), functionalizing them with targeting ligands, and characterizing the resulting targeted LNPs (tLNPs). The ideal candidate will have hands-on expertise in LNP formulation and characterization, bioconjugation, protein characterization, and automation technologies. Your work will unlock new understandings in the delivery space by enabling a high-throughput closed-loop screening cascade for tLNPs. This position will work closely with others across the protein, cell biology, automation, chemistry machine learning, and data science teams to help establish high-throughput next-generation tools for targeted nucleic acid delivery.

What You'll Be Building

• Design, execute, and characterize (DLS, ribogreen, TNS, etc.) LNP formulations across multiple scales and mixing modalities
• Develop and refine high-throughput ligand conjugation and purification methods, employing automation and robotics to increase throughput
• Collaborate with cell assay and antibody specialists to screen hits across a variety of tissue targets in in vivo models
• Collaborate with chemists, biologists, engineers, and data scientists to document systems, share insights, and refine best practices in autonomous flow chemistry
• Write, implement, and maintain Standard Operating Procedures (SOPs) for both existing and new lab processes

What You’ll Need to Succeed

• MSc in Chemical Engineering, Biomedical Engineering, Pharmaceutical Sciences, or a related field with 3+ years, or BSc with 5+ years, of hands-on experience in targeted LNP production, or related experience. Industry experience strongly preferred
• Strong working knowledge of bioanalytical techniques (e.g., DLS, fluorescence spectroscopy, electrophoresis, in vitro assays)
• Experience with protein and antibody design and characterization
• Familiarity with automation and high-throughput workflows
• Excellent troubleshooting, communication and collaboration skills, with a proven ability to work effectively across interdisciplinary teams

Your Impact at LILA

What You'll Be Building

• Lead and build a high-performing team of senior scientists, scientists, and research associates focused on nucleic acid delivery technology development.
• Drive the discovery and engineering of targeted lipid nanoparticle systems for delivery of nucleic acid therapeutics.
• Design and evaluate targeting ligands, conjugation strategies, and nanoparticle architectures that enable tissue- and cell-specific delivery.
• Develop and implement innovative biological assays and screening platforms to evaluate delivery efficiency, biodistribution, cellular uptake, and functional nucleic acid expression or editing.
• Leverage the Lila AI platform and AI Science Factory to accelerate design–build–test–learn cycles through AI-driven experimental design and robotics-enabled experimentation.
• Collaborate closely with formulation scientists to integrate biological targeting strategies with lipid chemistry and nanoparticle formulation optimization.
• Explore and evaluate next-generation delivery modalities that extend beyond traditional LNPs.
• Establish strategic scientific direction for nucleic acid delivery research and ensure alignment with company-wide therapeutic goals.
• Foster a culture of innovation, collaboration, and scientific rigor, mentoring team members and developing future leaders in the field.

What You’ll Need to Succeed

• PhD in molecular biology, bioengineering, chemical biology, biomedical engineering, pharmacology, or a related discipline with 8–10+ years of relevant industry or academic experience, or a BS/MS with 12–15+ years of experience in nucleic acid delivery or genetic medicine.
• Demonstrated expertise in lipid nanoparticle technologies, nucleic acid delivery systems, or related genetic medicine platforms.
• Strong track record of scientific leadership and mentorship, including managing multidisciplinary research teams.
• Experience designing and executing in vitro and in vivo assays to measure delivery efficiency, biodistribution, and functional activity of nucleic acid therapeutics.
• Deep understanding of the biological mechanisms underlying delivery, including cellular uptake, endosomal escape, tissue targeting, and intracellular trafficking.
• Experience collaborating across disciplines including formulation chemistry, molecular biology, protein engineering, and pharmacology.
• Track record of impactful scientific contributions demonstrated through publications, patents, or therapeutic development programs.
• Excellent communication and strategic thinking skills with the ability to translate complex scientific ideas into actionable research programs.

Bonus Points For

• Direct experience developing targeted LNP systems or ligand-directed nanoparticle delivery technologies.
• Expertise in RNA therapeutics, gene editing systems (e.g., CRISPR/Cas), siRNA, mRNA, or DNA therapeutics.
• Experience integrating AI-driven discovery tools, high-throughput experimentation, or automated laboratory platforms into biological research.
• Experience working in highly collaborative environments spanning biology, chemistry, computational science, and engineering.
• Demonstrated ability to translate early discovery concepts into therapeutically relevant delivery platforms.
• Entrepreneurial mindset with a passion for pushing the boundaries of AI-enabled scientific discovery.

About the Role:

Stylus Medicine is seeking an intellectually curious and collaborative Senior Scientist, who will lead the development of upstream microbial fermentation processes as part of our CMC Tech Ops team. This role will be responsible for process definition, development, characterization, scale-up and tech transfer from bench scale to pilot. Working closely with the Research, Preclinical, and Formulation teams, this is a special opportunity to advance the development of transformative in vivo genetic medicines.

Key Responsibilities & Accountabilities:

• Develop scalable production processes for nucleic acids and recombinant proteins
• Leverage expertise in fermentation and mammalian cell culture to design, optimize, scale-up and characterize production processes
• Independently utilize multivariate design of experiment (DoE) approaches to improve productivity and optimize parameters for product quality
• Drive fermentation platform development and new technology implementation to improve process performance, generation of predictive process models, and enhance process control and robustness
• Design and implement in-process analytics to improve productivity while reducing process and product derived impurities
• Maintain and troubleshoot equipment to ensure consistency and continuity of operations
• Document, analyze and present experimental results internally and externally
• Partner with CDMOs and provide technology transfer support to facilitate scale up
• Interface with cross-functional teams to ensure programs are on track and stakeholders’ needs are met
• Maintain accurate and reliable record keeping including database management, batch records, notebooks, and all other pertinent documentation

Qualifications & Skills:

• PhD in Chemical/Biomedical Engineering, Biochemistry, Pharmaceutical Sciences, or related discipline with >4 years of experience, or BS/MS with >8 years of experience in biopharmaceutical or biotechnology development, including experience in developing scalable fermentation processes for producing plasmid DNA and/or recombinant products
• In-depth experience and knowledge in fermentation process development, optimization, and process scale-up / scale-down model development
• Familiarity with strain engineering and biocatalysis
• Familiarity with performing operations in a cleanroom environment, applying controls to ensure aseptic processing
• Demonstrated ability to coach and mentor junior researchers
• Independently motivated and good problem-solving ability
• Attention to detail and accuracy in developing, reviewing, and following protocols, SOPs, batch records and technology transfer documents is a must
• Demonstrated ability to work collaboratively across teams to meet project deliverables and timelines
• Strong communication, decision-making and organizational skills
• Proficiency with statistical analysis software (e.g., JMP) is highly desired
• Prior experience partnering with external CDMOs and conducting tech transfers preferred

Pay Range: $155,000 - $170,000

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As an MSAT Associate Director, you will report to the Executive Director of MSAT to support manufacturing of Sana’s stem cell-derived pancreatic islet cell program for persons with type 1 diabetes (SC451). You will lead an MSAT team responsible for the pancreatic cell maturation and aggregation process to generate DP at an external manufacturing partner. You will define and execute the technology transfer strategy in alignment with program timelines. Your team will provide technical coverage at the external manufacturing partner throughout the phase I manufacturing campaign including people-in-plant, executed batch record review, investigations, and batch summaries. You will collaborate with internal partners across Quality, External Manufacturing, and Supply Chain to complete batch disposition. You will draft applicable CMC sections of regulatory documents (IND module 3).  You will provide your team members with technical guidance and mentorship.   

What you’ll do

• Lead a team of 1-2 individuals supporting phase I manufacturing of a PSC-derived pancreatic islet cell therapy product
• Partner with CDMO technical team to achieve phase I manufacturing readiness and address manufacturing challenges
• Oversee people-in-plant, manufacturing operator training, technical documentation, and process execution
• Draft CMC sections for regulatory filings (IND module 3) and other technical documents
• Collaborate with Quality to close deviations, analyze manufacturing trends, and recommend process improvements
• Lead investigations and troubleshoot process execution challenges by applying root cause analysis
• Perform comparability studies in collaboration with Research and PD teams to assess technology transfer success
• Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment
• Innate ability to assess talent that will help grow the organization and add to Sana’s culture

What we’re looking for

• BSc. in Chemical, Biological, or Biomedical Engineering plus 8 yrs or equivalent combination of education and work experience
• >3 year experience supporting early phase cell therapy manufacturing including technology transfers
• Well versed with cGMP requirements and experience working in a regulated environment, including as person-in-plan and/or GMP operator/supervisor
• Experience operating perfusion bioreactors and with fill/finish unit operations
• Knowledge of PSC culture and differentiation biology to pancreatic islets
• Experience managing a team of >2 direct reports
• Detail-oriented with good problem-solving, technical writing and verbal communication skills
• Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects
• Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment

What will separate you from the crowd

• Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials including PBS bioreactor
• Familiarity with cell therapy drug product development, including stability studies
• Working knowledge of statistical design of experiments (DoE) and RCA
• Experience working in grade B / ISO 7 cleanroom
• Knowledge of single-use technologies applicable to cell therapies
• Experience with process closure and automation
• Understanding of analytical methods such as flow cytometry
• Familiar with data analysis tools such as R, Python, JMP and FlowJo software

What you should know

• Travel to the manufacturing site ~25% of the time (Texas)
• Some weekend work required
• Lift up to 25 lbs
• Work within a cleanroom environment
• The base pay range for this position at commencement of employment is expected to be between $170,000 and $210,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

About the role  

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who want to challenge the status quo, and who lead with the desire to work on novel ideas. You will join the Beta Islet Team at the Cambridge location to optimize 3D expansion and differentiation in stem cell (SC)-islet differentiation. As a Senior Scientist, you will execute optimization experiments critical to scaling up our differentiation process. The ideal candidate should have ample experience handling bioreactors and performing directed PSC differentiation in 3D. The ability to work in a highly collaborative environment and learn from each other will be essential to your success.

What you’ll do

• Execute routine 2D and 3D PSC expansion, passaging and directed SC-islet differentiation
• Design optimization experiments with the goal to achieve a highly scalable and robust 3D SC-islet differentiation process that is compliant to manufacturing standards
• Optimize the differentiation protocol to achieve highly pure on-target populations
• Hands-on experience with closed systems (tube welder, sealer, single-use assemblies)
• Expertise in controlled bioreactor setup, operation, automation, and process control (DO, pH, perfusion, agitation)
• Collaborate and communicate findings with other team members
• Maintain excellent scientific documentation and contribute to SOP development
• Assure compliance with all relevant lab safety and biosafety regulations
• Demonstrate Sana’s core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen)
• Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team member
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor, and excellent problem-solving skills across a fast-paced performance-driven environment
• Innate ability to assess talent that will help grow the organization and add to Sana’s culture

What we’re looking for

• PhD in Stem cell biology, biochemical/biomedical Engineering or related fields with 3-5 years of direct cell therapy industry experience
• Significantly experienced and knowledgeable in operating various types of bioreactors for suspension culture.
• Experienced with bioreactor control software, process development tools, or DOE-base optimization is preferred
• Significantly experienced in operating a closed system for cell culture
• Significantly experienced in Flow cytometry, Immunofluorescent staining,
• Proficient with standard flow cytometry and imaging software (e.g. FACSDiva, FlowJo, ImageJ, Halo, etc.) 

What will separate you from the crowd   

• Knowledge or direct experience in directed stem cell differentiation toward pancreatic islet lineage
• Proven ability to optimize differentiation yield and reproducibility across platforms
• Passion for GMP transition, automation, and continuous process improvement
• Strong cross-functional collaboration skills and enthusiasm for advancing cell therapies to the clinic
• Significant experience in operating large bioreactors (15L+) for cell therapy purposes
• Expertise in controlled bioreactor setup, operation, automation, and process control (DO, pH, perfusion, agitation)
• Proven ability to optimize differentiation yield and reproducibility across platforms

What you should know

• The base pay range for this position at commencement of employment is expected to be between $160,000 and $190,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas. As an MSAT Director, you will report to the Executive Director of MSAT and support manufacturing of Sana’s stem cell-derived pancreatic islet cell program for persons with type 1 diabetes (SC451). You will lead an MSAT team responsible for the PSC seed train and differentiation to beta cells at an external partner. You will define and execute the technology transfer strategy in alignment with program timelines and provide your team with technical mentorship. Your team will provide technical coverage at an external manufacturing partner throughout the phase I manufacturing campaign including people-in-plant, executed batch record review, investigations, and batch summaries. You will collaborate with internal partners across Quality, External Manufacturing, and Supply Chain to complete batch disposition. You will draft applicable CMC sections of regulatory documents (IND module 3). 

What you’ll do

• Lead a team of 2-4 individuals supporting Phase I manufacturing of a PSC-derived pancreatic islet cell therapy product
• Partner with CDMO technical team to achieve manufacturing readiness and address technical challenges
• Oversee people-in-plant, manufacturing operator training, technical documentation, and process execution
• Author CMC sections for regulatory filings (IND module 3) and other technical documents
• Collaborate with Quality to close deviations, analyze manufacturing trends, and recommend process improvements
• Lead investigations and troubleshoot process execution challenges including root cause analysis
• Perform comparability studies in collaboration with Research and PD teams to assess technology transfer success
• Engage in crucial conversations by providing and receiving feedback supporting the growth and development of team members
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment
• Innate ability to assess talent that will help grow the organization and add to Sana’s culture

What we’re looking for

• BSc. in Chemical, Biological, or Biomedical Engineering plus 10 yrs or equivalent combination of education and work experience
• >5 year experience supporting early phase cell therapy manufacturing including technology transfers
• Well versed with cGMP requirements and working in a regulated environment, including experience as person-in-plan and/or GMP operator
• Knowledge of PSC culture and differentiation biology to pancreatic islets
• Experience managing a team of >3 direct reports
• Detail-oriented with good problem-solving, technical writing and verbal communication skills
• Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects
• Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment

What will separate you from the crowd

• Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials including cryopreservation
• Working knowledge of statistical design of experiments (DoE) and RCA
• Experience working in grade B / ISO 7 cleanroom
• Understanding of analytical methods such as flow cytometry
• Experience with cell therapy process closure and automation
• Knowledge of single-use technologies as applicable to cell therapies
• Familiar with data analysis tools such as R, Python, JMP and FlowJo software

What you should know

• Travel to the manufacturing site ~25% of the time (Canada)
• Some weekend work required
• Lift up to 25 lbs
• Work within a cleanroom environment
• The base pay range for this position at commencement of employment is expected to be between $200,000 and $250,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience

About the role

Sana Biotechnology is growing, and we are hiring new team members who believe in the potential of engineered cells as medicines, who are passionate about delivering the possible to patients, and who lead with the desire to work on novel ideas.  As an MSAT Engineer, you will report to the Executive Director of MSAT and support manufacturing of Sana’s stem cell-derived pancreatic islet cell program for persons with type 1 diabetes (SC451).  You will support technology transfers to external manufacturing partners.  This will include authoring sections of process descriptions and master batch records.  You will travel to the manufacturing partner to train operators and provide in-suite support as person-in-plant during phase 1 clinical manufacturing.  You will participate in investigations leveraging RCA tools. You will compile run summaries, track process performance indicators, and periodically update stakeholders on manufacturing progress.

What you’ll do

• Support technology transfers and author technical documents including reports, standard operating procedures, master batch records, and work instructions
• Travel to external manufacturing partners to serve as person-in-plant, train manufacturing operators, and oversee process execution
• Review executed batch records, collaborate with QA to close process deviations, analyze manufacturing trends, and recommend improvements
• Support investigations to troubleshoot process execution challenges including root cause analysis
• Collaborate with Research and PD teams to learn and document the process, and execute studies in the PD lab
• Demonstrate ability to engage and effectively influence team members across multidisciplinary teams while prioritizing multiple projects and meeting deadlines
• Drive curiosity, scientific rigor and excellent problem-solving skills across a fast-paced performance driven environment

What we’re looking for

• Bsc. in Chemical, Biological, or Biomedical Engineering plus 4 yrs or MSc plus 2 yrs or equivalent combination of education and work experience
• >1 year experience supporting early phase cell therapy manufacturing
• Well versed with cGMP requirements and working in a regulated environment, including experience as person-in-plan and/or GMP operator
• Detail-oriented with good problem-solving, technical writing and verbal communication skills
• Ability to effectively work in multidisciplinary teams, meet deadlines, and prioritize multiple projects
• Aptitude for working in a self-driven, performance/results-oriented, fast-paced matrix environment

What will separate you from the crowd

• Knowledge of PSC culture and differentiation biology to pancreatic islets
• Experience with key cell therapy equipment and unit operations to support phase 1 clinical trials
• Working knowledge of statistical design of experiments (DoE) and RCA
• Experience working in grade B / ISO 7 cleanroom
• Understanding of analytical methods such as flow cytometry
• Excellent technical writing skills, including drafting technology transfer packages
• Familiar with data analysis tools such as R, Python, JMP and FlowJo software

What you should know

• Travel to the manufacturing site up to 50% of the time (Texas and Canada)
• Work in a laboratory environment ~25% of the time
• Some weekend work required
• Lift up to 25 lbs
• Work within a cleanroom environment
• The base pay range for this position at commencement of employment is expected to be between $120,000 and $150,000/year; however, base pay offered may vary depending on multiple individualized factors, including market location, job-related knowledge, skills, and experience