Scientist I - RNA Therapeutic Discovery (6-month contract)

Ascidian is redefining the treatment of disease by rewriting RNA.

Ascidian Therapeutics was founded to rewrite RNA by editing and replacing human exons. We were inspired by ocean creatures, called Ascidians, who are primordial ancestors of vertebrates. To grow from larvae to adults, ascidians re-engineer their transcriptome through RNA editing via trans-splicing and alternative splicing.

In our Brighton/Boston labs, RNA biology meets today's cutting-edge genomics, computational biology, and deep-sequencing technologies to create a new class of medicines that address the underlying causes of disease. We welcome you to come join our vibrant team and help us lead the way into a new gene therapy era.

YOUR ROLE ON THE TEAM

We are seeking a Contract Scientist I with strong cell and molecular biology experience to join the RNA Therapeutic Discovery Team. In this contractor role, the selected individual will contribute to ongoing research efforts by designing and executing experiments to advance novel RNA therapeutics.. The successful candidate will be creative, detail oriented, have excellent communication skills, and be willing to work in a dynamic environment. A commitment to the collective success of the team is essential.

JOB RESPONSIBILITIES

• Design, execute, and interpret experiments to improve therapeutic performance of designer RNA molecules
• Support research activities that contribute to the company’s intellectual property portfolio
• Interpret data, generate figures, and clearly communicate findings to the team
• Maintain accurate and detailed records using ELN

SKILLS/CAPABILITIES

• Extensive hands-on experience with mammalian cell culture, particularly iPSCs and iPSC-derived cell models
• Proven expertise in working with AAV vectors, including handling, titration, and transduction in challenging cell types (e.g., iPSC-derived cells)
• Proficiency with basic molecular biology techniques: plasmid design, cloning, primer design and PCR, DNA isolation, gel electrophoresis, Sanger sequencing analysis
• Proficiency with RNA extraction and quantification by qPCR and ddPCR
• Protein extraction and western blot
• Eagerness to learn and receptive to feedback
• Demonstrated problem solving and troubleshooting skills

REQUIRED EDUCATION/EXPERIENCE

• Ph.D. in molecular/cellular biology, biochemistry, genetics, or related field with 5+ years relevant laboratory experience
• Background in RNA, muscle biology, cardiac biology, and/or neuroscience

If you feel energized by what you read here, but aren’t sure you meet every requirement, please consider applying! We believe diverse backgrounds lead to innovative thinking that enables effective treatment for millions of patients.  Above all, we’re looking for the right person with skills and talent to grow the company together all while enriching your professional and scientific experience.