Tango Therapeutics
Tango is a team of passionate problem solvers. Our discovery efforts begin and end with patients. We are driven by urgency and compassion, empowered by collaboration, courage and a culture of excellence – determined to push boundaries with innovative science and bold decisions.
Together, we will discover transformative drugs for people with cancer by leveraging the classic principles of synthetic lethality in innovative ways. Our approaches are uncovering novel vulnerabilities in cancers with specific tumor suppressor gene loss and undruggable oncogenes, as well as discovering drug targets that reverse the ability of cancer cells to avoid immune destruction.
We’re a team. And we’re all in for exciting science and changing lives.
If you share our passion for discovering transformative cancer medicines and our deep commitment to making a difference for people with cancer and their families, please explore our current opportunities.
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Scientific Director, Medical Information & Medical Communications
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Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
In this newly created role, the Scientific Director, Medical Information & Medical Communications will serve as a senior individual contributor within Medical Affairs, responsible for owning the medical information foundation and scientific narrative across Tango’s pipeline.
This role will be central to ensuring Tango is prepared to support increasing external engagement, regulatory interactions, congress presence, publications, and future commercialization. This is an exciting opportunity to shape foundational capability during a period of significant clinical and organizational inflection.
Your Role
Medical Information Strategy & Operations
- Lead the end-to-end medical information strategy, including oversight of external MI vendors and call center operations
- Ensure timely, accurate, compliant, and evidence-based responses to external inquiries
- Develop, maintain, and govern medical information content, including SRLs, CRLs, FAQs, and response guidance
- Own medical information SOPs, KPIs, quality metrics, audit readiness, and inspection preparedness
- Ensure alignment with pharmacovigilance, regulatory, and compliance requirements
Scientific Narrative & Medical Communications
- Develop and maintain Tango’s core scientific platform and data narrative across indications and development stages
- Translate complex clinical, nonclinical, and mechanistic data into clear and compelling content for internal and external audiences
- Ensure consistency of scientific messaging across medical information, field materials, congress assets, and internal communications
Publications, Congress, & Content Governance
- Partner with Medical Affairs and Clinical teams to support publication planning and execution
- Oversee development of scientific materials for major medical congresses
- Provide medical information support at congresses, as appropriate
- Participate in the Medical Review process to ensure scientific accuracy, compliance, and data integrity
Cross-Functional Collaboration
- Collaborate closely with Medical Affairs leadership, Clinical Development, Regulatory Affairs, Corporate Communications, and Commercial (as appropriate and compliant)
- Ensure alignment between scientific communications, medical strategy, and enterprise objectives
- Perform additional duties as required to support Medical Affairs goals
What You Bring
- Advanced scientific degree required (PharmD, PhD, or MD strongly preferred)
- 7–10+ years of experience in Medical Affairs, Medical Information, or Scientific/Medical Communications
- Oncology experience strongly preferred; experience in GI malignancies, NSCLC, or precision oncology highly valued
- Experience in clinical-stage and/or pre-commercial biotech environments
- Exceptional scientific writing, editing, and data-positioning skills
- Strong understanding of clinical development, regulatory pathways, and medical affairs operations
- Demonstrated ability to manage vendors, agencies, and cross-functional stakeholders
- Experience with Veeva MedComms and PromoMats preferred
- Ability to operate effectively through ambiguity in a resource-constrained environment
- Excellent written and oral communication skills
Work Environment
- This role may be remote, with periodic travel to Tango offices and scientific meetings
- Approximately 10–20% travel
#LI-Remote
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
Ready to apply?
Apply to Tango Therapeutics
Senior Medical Science Liaison (Texas/U.S. Oncology)
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Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.
The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.
This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.
Your role
Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)
Scientific Exchange & External Engagement
- Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
- Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
- Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC
Clinical Development & Trial Execution Support
- Support Tango-sponsored clinical trials, with emphasis on:
- Site identification and activation
- Enrollment support and investigator engagement
- Ongoing scientific dialogue to enhance trial conduct
- Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
- Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution
Insight Generation & Strategic Contribution
- Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
- Trial design and execution
- Competitive landscape
- Future evidence needs
- Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
- Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve
Advisory Boards, Congresses & Scientific Presence
- Support planning and execution of advisory boards, investigator meetings, and other scientific forums
- Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
- Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution
Cross-Functional Collaboration & Compliance
- Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
- Serve as a scientific resource to internal stakeholders
- Uphold the highest standards of compliance, scientific integrity, and ethical engagement
What You Bring
Education & Experience
- 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
- Experience in PDAC, GI malignancies, or NSCLC strongly preferred
- Prior experience supporting clinical-stage or pre-launch oncology assets highly valued
Skills & Attributes
- Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
- Demonstrated strength in insight generation, synthesis, and communication
- Comfortable operating in a fast-moving, high-accountability biotech environment
- Excellent collaboration skills across matrixed teams
- Strong understanding of U.S. clinical research and healthcare environments
Compliance & Technical Requirements
- Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
- Commitment to compliant, ethical scientific exchange
- Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)
Work Environment
- Field-based role in Texas, with residence required within assigned territory
- ~ 50% domestic travel expected, with significant time spent with external scientific partners
Why Join Tango Medical Affairs?
- Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
- Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
- Expand and establish Tango as a credible clinical scientific leader in precision oncology
- Work in a lean, collaborative environment where your scientific judgment and execution matter
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
#LI-Remote
Ready to apply?
Apply to Tango Therapeutics
Senior Medical Science Liaison (Northeast/U.S. Oncology)
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Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.
The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.
This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.
Your role
Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)
Scientific Exchange & External Engagement
- Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
- Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
- Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC
Clinical Development & Trial Execution Support
- Support Tango-sponsored clinical trials, with emphasis on:
- Site identification and activation
- Enrollment support and investigator engagement
- Ongoing scientific dialogue to enhance trial conduct
- Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
- Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution
Insight Generation & Strategic Contribution
- Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
- Trial design and execution
- Competitive landscape
- Future evidence needs
- Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
- Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve
Advisory Boards, Congresses & Scientific Presence
- Support planning and execution of advisory boards, investigator meetings, and other scientific forums
- Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
- Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution
Cross-Functional Collaboration & Compliance
- Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
- Serve as a scientific resource to internal stakeholders
- Uphold the highest standards of compliance, scientific integrity, and ethical engagement
What You Bring
Education & Experience
- 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
- Experience in PDAC, GI malignancies, or NSCLC strongly preferred
- Prior experience supporting clinical-stage or pre-launch oncology assets highly valued
Skills & Attributes
- Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
- Demonstrated strength in insight generation, synthesis, and communication
- Comfortable operating in a fast-moving, high-accountability biotech environment
- Excellent collaboration skills across matrixed teams
- Strong understanding of U.S. clinical research and healthcare environments
Compliance & Technical Requirements
- Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
- Commitment to compliant, ethical scientific exchange
- Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)
Work Environment
- Field-based role in the Northeast (Boston/New York), with residence required within assigned territory
- ~ 50% domestic travel expected, with significant time spent with external scientific partners
Why Join Tango Medical Affairs?
- Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
- Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
- Expand and establish Tango as a credible clinical scientific leader in precision oncology
- Work in a lean, collaborative environment where your scientific judgment and execution matter
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
#LI-Remote
Ready to apply?
Apply to Tango Therapeutics
Senior Medical Science Liaison (California/U.S. Oncology)
Share this job
Company Overview
Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer.
Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer.
This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing.
The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts.
Summary
The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development.
The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs.
This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters.
Your role
Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC)
Scientific Exchange & External Engagement
- Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC
- Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy
- Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC
Clinical Development & Trial Execution Support
- Support Tango-sponsored clinical trials, with emphasis on:
- Site identification and activation
- Enrollment support and investigator engagement
- Ongoing scientific dialogue to enhance trial conduct
- Act as a Medical Affairs bridge between investigators and internal Clinical Development and Clinical Operations teams
- Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution
Insight Generation & Strategic Contribution
- Capture and synthesize high-quality, hypothesis-driven insights from the field related to:
- Trial design and execution
- Competitive landscape
- Future evidence needs
- Translate insights into actionable feedback that informs Medical Strategy, Clinical Development, and future regulatory and commercialization readiness
- Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve
Advisory Boards, Congresses & Scientific Presence
- Support planning and execution of advisory boards, investigator meetings, and other scientific forums
- Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology
- Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution
Cross-Functional Collaboration & Compliance
- Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners
- Serve as a scientific resource to internal stakeholders
- Uphold the highest standards of compliance, scientific integrity, and ethical engagement
What You Bring
Education & Experience
- 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.
- Experience in PDAC, GI malignancies, or NSCLC strongly preferred
- Prior experience supporting clinical-stage or pre-launch oncology assets highly valued
Skills & Attributes
- Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data
- Demonstrated strength in insight generation, synthesis, and communication
- Comfortable operating in a fast-moving, high-accountability biotech environment
- Excellent collaboration skills across matrixed teams
- Strong understanding of U.S. clinical research and healthcare environments
Compliance & Technical Requirements
- Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards
- Commitment to compliant, ethical scientific exchange
- Proficiency in standard business and field tools (CRM, MS Office, virtual engagement platforms)
Work Environment
- Field-based role in California, with residence required within assigned territory
- ~ 50% domestic travel expected, with significant time spent with external scientific partners
Why Join Tango Medical Affairs?
- Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development
- Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways
- Expand and establish Tango as a credible clinical scientific leader in precision oncology
- Work in a lean, collaborative environment where your scientific judgment and execution matter
We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
#LI-Remote
Ready to apply?
Apply to Tango Therapeutics