Job Title: Sample Management Associate (Contract)

Location: South San Francisco, CA 

Full-Time: Monday-Friday

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

The Role:

We are seeking a detail-oriented Sample Management Associate to join our team. The ideal candidate will be responsible for managing our sample inventory, processing sample requests, and ensuring accurate tracking and documentation using Benchling. This role is critical in supporting our research and development efforts through organized sample management. The role is temporary (6 months) and will be full time on-site Monday-Friday.

What You Will Do:

• Manage and maintain the sample inventory, including receipt, labeling, and storage of samples in accordance with company guidelines.
• Utilize Benchling to track and manage sample information, including creating, updating, and archiving sample records.
• Process sample requests from researchers and ensure timely delivery and documentation of samples.
• Collaborate with laboratory teams to maintain accurate records and resolve any discrepancies related to sample data.
• Assist in the implementation of best practices for sample management to improve workflow efficiency.
• Ensure compliance with safety and regulatory standards related to sample handling and storage.
• Participate in data audits and contribute to maintaining the integrity of the sample management system.
• Support additional projects and tasks as needed to further enhance sample management operations.

What You Will Bring:

Qualifications:

• Bachelor’s degree in Life Sciences, Biotechnology, or a related field.
• Experience with sample management, laboratory operations, or inventory management preferred.
• Proficiency in using Benchling or similar laboratory management systems.
• Strong organizational skills and attention to detail.
• Excellent communication and teamwork abilities.
• Ability to work independently and manage multiple tasks effectively in a dynamic environment.

Technical Requirements and Skills:

1. Familiarity with Benchling:
• Proficient in using Benchling for sample tracking, data entry, and inventory management.
2. Data Entry and Management:
• Strong skills in accurate data entry, maintenance, and management of sample records and databases.
3. Sample Tracking and Documentation:
• Understanding of best practices for tracking samples, managing storage conditions, and maintaining documentation.
4. Lab Techniques and Protocols:
• Basic knowledge of laboratory techniques relevant to sample handling and processing, such as pipetting, labeling, and storage requirements.

Compensation: The salary range for this position is $30 to $40 USD hourly. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. 

Job Title: Senior/Principal Scientist – Gene Therapy Vectors Innovation

Location: South San Francisco, CA

Reports to: Associate Director, Gene Therapy 

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies. 

The Role:

The Gene Therapy group at SonoThera is seeking to hire a Senior/Principal Scientist to become an integral part of the gene therapy drug development effort. We are looking for candidates who demonstrate strong managerial capabilities in high pace small biotech environment along with strong aptitude for innovation in the gene therapy vector development field. This position requires adaptability and the ability to excel in a fast-paced start-up environment. The ideal candidate will have extensive technical experience and a proven record of innovation in the field of gene therapy vectors development and manufacturing.

What You Will Do:

• Support the innovative efforts in developing gene therapy vectors
• Managing a team of 2-4 scientists ranging from Research Associate to Associate Scientist levels.
• Provide day-to-day support for vector development team operations, including but not limited to vector design generation, maintenance of research records, and management of vector and oligonucleotide inventories
• Work in close connection with project management team and manage vector development activities, leveraging advanced project management tools such as SmartSheet to ensure accurate timelines, resource allocation, and milestone delivery.
• Manage external and internal collaboration activities
• Scope open-source resources to identify technologies that address major limitations in the delivery of non-viral gene therapy vectors.
• Establish novel development and manufacturing procedures for scalable production of next-generation DNA and RNA payloads.

Qualifications:

• A PhD in biological sciences (e.g., Genetics, Biochemistry, Molecular and Cellular Biology, or a related field), with minimum 6+ years of experience in an industry setting.
• 2-4 years of experience in managing a research team in a high pace small biotech environment
• Meticulous attention to detail and effective communication of complex task details to the research team
• Demonstrated creativity and the ability to work effectively within an interdisciplinary team
• Demonstrated ability to lead and support a team with a balanced approach that is both collaborative and results driven.
• Excellent verbal and written communication skills, along with strong critical thinking and problem-solving abilities.

Technical Requirements & Skills:

• Demonstrated success in developing potent and safe gene therapy payloads for both viral and non-viral delivery, evidenced by first authorship in peer-reviewed publications, patents, and presentations at major international gene therapy conferences.
• Strong working knowledge of enzymatic and cell-based nucleic acid manufacturing processes.
• Extensive experience in literature mining and designing DNA- and RNA-based gene therapy payloads.
• Ability to efficiently coordinate the daily activities of the research team in close collaboration with the project management team.
• Proficiency in using Geneious, Benchling, and SmartSheet platforms.
• An ideal candidate will have familiarity with gene editing and high throughput screening technologies.
• Strong record-keeping and organizational skills.

Benefits:  

We offer our employees a comprehensive benefits package.  

At SonoThera, we'll give you the tools to feel healthy, happy and secure.  

🏋🏻 Access to a 24-hour onsite gym  

💝 Comprehensive medical, dental, and vision  

💰 Equity and ownership in a fast-growing company  

🚗 Commuting stipend based on your geographical location  

🏦 401(k) Match: SonoThera offers a company match  

🏝 All full-time employees are eligible for our flexible time off policy  

Compensation: The salary range for this position is $150,000.00 to $206,000.00 USD annually. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location. 

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.  

Job Title: Scientist I - Analytical Chemistry (Contract)

Location: South San Francisco, CA (local candidates only)

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

The Role:

The Gene Therapy group at SonoThera is seeking to hire a Scientist I (temporary) to become an integral part of the gene therapy drug development effort. We seek candidates who think critically and have the desire and ability to learn new techniques. This position requires adaptability and an ability to perform at a high level in a fast-paced environment. The ideal candidate will leverage their mass spectrometry and chromatography expertise to develop assays in support of SonoThera’s gene therapy programs. This is a 7-month full-time contract role.

What You Will Do:

• Develop targeted proteomic assays to support drug product characterization
• Use LC-MS QQQ/QTrap for MRM/SRM analysis (Shimadzu, Agilent, Waters, ExionLC AE, Sciex), including method development, routine instrument maintenance, and troubleshooting
• Analyze quantitative proteomics data using proteomics analysis software (Skyline, SciexOS) and bioinformatics tools for protein and peptide quantification
• Research literature and external sources to identify new techniques and procedures

What You Will Bring:

• Ph.D. with 0-3 years, M.S. with 6+ years, or B.S. with 8+ years of industry experience in analytical chemistry, chemical biology, biochemistry or a related field
• Creativity and the ability to work within an interdisciplinary team to achieve technical and corporate milestones
• Strong verbal and written communication, critical thinking, and problem-solving skills
• Familiarity with ELNs (ie: Benchling)
• Strong record-keeping and organizational skills
• Working knowledge with recombinant protein downstream purification and characterization (nice to have)
• Familiarity with Olink-based proteomics, MSD, Western blot, metabolomics and unbiased proteomics analysis (nice to have)

Compensation: The hourly range for this position is $50 to $60 USD. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location. 

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

Job Title: Executive Assistant
Location: South San Francisco, CA
Reports to: CEO
Full/Part-Time: Full-Time, on-site Monday-Thursday
Regular/Temporary: Regular

About SonoThera:
SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

The Role:

SonoThera is seeking an exceptional Executive Assistant to serve as a trusted right hand to the CEO and a critical partner in enabling executive effectiveness. This role is central to how the CEO operates day-to-day—owning time management with precision, orchestrating complex schedules and travel, and ensuring flawless execution across internal and external engagements, including board and investor interactions.
The ideal candidate operates with exceptional judgment, discretion, and attention to detail. They are highly proactive and anticipate needs before they arise, seamlessly managing competing priorities in a fast-paced, high-performance environment. This individual is calm under pressure, communicates with clarity and professionalism, and takes pride in delivering work at an exceptionally high standard. They are deeply reliable, solutions-oriented, and capable of representing the CEO and the company with polish and credibility.

What You Will Do:

• Serve as a trusted partner to the CEO, proactively managing priorities, time, and focus to maximize effectiveness
• Own and orchestrate complex calendars for the CEO and select members of the leadership team, ensuring alignment across internal priorities and external commitments
• Coordinate and execute domestic and international travel with precision, including detailed itineraries and seamless logistics
• Lead end-to-end planning and execution of meetings and events, including executive staff meetings, board meetings, investor interactions, and key internal forums
• Anticipate needs and ensure the CEO and leadership team are well-prepared for all meetings and commitments
• Track key action items and follow through to ensure timely execution across leadership priorities
• Facilitate coordination across teams to support effective communication and execution
• Provide high-impact administrative and operational support on special projects as needed

Qualifications:

• Bachelor’s degree and 5+ years of experience providing high-level executive support in a fastpaced,
  high-performance environment
• Proven experience supporting C-level executives, ideally in a startup, biotech, or life sciences
  setting
• Exceptional organizational and prioritization skills, with the ability to manage multiple,
  competing demands with precision and efficiency
• Demonstrated ability to anticipate needs, exercise sound judgment, and operate with a high
  degree of autonomy
• Strong execution skills with the flexibility to adapt quickly in a dynamic, evolving environment
• Excellent written and verbal communication skills, with a high level of professionalism and
  attention to detail
• High degree of discretion, integrity, and ability to handle sensitive and confidential information
• Advanced proficiency in Microsoft Office (Outlook, Teams, PowerPoint, Excel, Word)
• Resourceful, solutions-oriented mindset with a focus on continuous improvement and operational
  excellence
• Collaborative team player with a positive, polished, and professional presence

Preferred Qualifications:

• Experience supporting board meetings and investor communications
• Prior experience in a high-growth or venture-backed company
• Notary Public certification

Benefits:  

We offer our employees a comprehensive benefits package.  

At SonoThera, we'll give you the tools to feel healthy, happy and secure.  

🏋🏻 Access to a 24-hour onsite gym  

💝 Comprehensive medical, dental, and vision  

💰 Equity and ownership in a fast-growing company  

🚗 Commuting stipend based on your geographical location  

🏦 401(k) Match: SonoThera offers a company match  

🏝 All full-time employees are eligible for our flexible time off policy  

Compensation: The salary range for this position is $115,000.00 to $150,000.00 USD annually.. This salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location. 

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. 

Job Title: Oligo Synthesis and Purification Intern

Location: South San Francisco, CA (local candidates only)

Reports to: Scientist, Nucleic Acid Chemistry

Regular/Temporary: Temporary (Summer Internship)

Full/Part-Time (if part-time, number of hours each week): Monday-Friday

Internship Duration (10-12 weeks): Start Date (May/June) – End Date (August/September)

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

Program Overview

The Summer Internship Program provides hands-on experience designed to complement academic learning. Over the course of the program, interns will gain exposure to real-world projects, collaborate with cross-functional teams, and receive structured mentorship and feedback. We are seeking a highly motivated Summer Intern to join our team, where you will assist in the synthesis and purification of oligonucleotides. This hands-on role will offer the opportunity to gain practical experience in laboratory techniques related to oligo synthesis and purification, contributing directly to our research and development efforts. Applicants must be authorized to work in the United States without the need for current or future visa sponsorship.

Role Summary

The Oligo Synthesis and Purification Intern will play a key part in supporting the team’s goal of producing high-quality oligonucleotides for research and production purposes. As a summer intern, you will work closely with experienced scientists and technicians in the lab, learning essential techniques and ensuring the quality of synthesized products. Your work will directly interface with team members in oligo synthesis, quality control, and laboratory operations, contributing to efficient project execution and deadlines. 

Key Responsibilities

Learning Objectives

By the end of this internship, the Oligo Synthesis and Purification Intern will:

• Assist in the preparation, synthesis, and purification of oligonucleotides under the guidance of scientists. 
• Conduct quality control testing to ensure the purity and integrity of synthesized products.
• Maintain detailed lab records, including experimental setups, results, and observations.
• Participate in troubleshooting and optimizing oligo synthesis and purification processes. 
• Support lab organization, inventory management, and general housekeeping tasks to maintain a productive work environment. 
• Gain exposure to laboratory instrumentation such as oligo synthesizers, HPLC, and other purification tools. 

Qualifications

• Currently enrolled or anticipated to graduate within 1 year from a graduate degree program (Bachelor’s or Master's) in biochemistry, chemistry, chemical biology, or a related field. Recent graduates (within 18 months of post-degree) are also encouraged to apply.
• No prior professional experience is required, but laboratory experience or coursework related to chemistry is preferred.
• Strong academic background with demonstrated interest in chemistry and laboratory work.
• Ability to work effectively in ateam environment and collaborate with others to achieve common goals. 

Technical Requirements and Skills

• Basic understanding of oligonucleotide synthesis and purification techniques principles.
• Familiarity with laboratory equipment such as automated synthesizers, and HPLC systems.
• Good attention to detail and accuracy when performing laboratory tasks.
• Strong organizational and record-keeping skills to ensure compliance with protocols and maintain lab safety.
• Ability to communicate effectively, both orally and in writing, to report results and share observations with team members.
• A proactive and enthusiastic attitude towards learning new techniques and problem-solving in the laboratory.

Compensation: The is a paid internship. Hourly pay is based on current degree level

• Pursuing Bachelor’s degree: $27.00 per hour
• Pursuing Master’s (MS) degree: $30.00 per hour

Compensation is determined based on verified academic enrollment at the time of hire.

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.  

Job Title: DNA Purification Intern

Location: South San Francisco, CA (local candidates only)

Reports to: Senior Research Associate, Downstream Process Development

Temporary (Summer Internship)

Full-Time: Monday-Friday

Internship Duration (10-12 weeks): Start Date (May/June) – End Date (August/September)

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

Program Overview

The Summer Internship Program provides hands-on experience designed to complement academic learning. Over the course of the program, interns will gain exposure to real-world projects, collaborate with cross-functional teams, and receive structured mentorship and feedback.

Applicants must be authorized to work in the United States without the need for current or future visa sponsorship.

Role Summary

The DNA Purification Intern will play a key part in supporting the team’s goal of producing high-quality gene therapy vectors. The intern will work closely with experienced scientists and technicians in the lab, learning essential DNA purification techniques and contributing to maintaining the quality of manufactured products.

In this role, the intern will collaborate with members of the gene therapy and laboratory operations teams to support efficient project execution and meet critical deadlines. This DNA Purification Internship offers a valuable opportunity to gain hands-on experience in laboratory methods while directly contributing to our gene therapy drug development efforts.

Key Responsibilities

Learning Objectives

By the end of this internship, the intern will:

• Assist in downstream purification of DNA gene therapy vectors at small and large scale under the guidance. 
• Perform analytical assays to evaluate the quality of purified DNA.
• Maintain detailed lab records, including experimental setups, results, and observations.
• Participate in troubleshooting and optimizing purification processes. 
• Support lab organization, inventory management, and general housekeeping tasks to maintain a productive work environment. 

Qualifications

• Currently enrolled in undergraduate or graduate program. 
• No prior professional experience is required, but laboratory experience or coursework related to biology or chemistry is preferred. 
• Strong academic background with demonstrated interest in chemistry and laboratory work. 
• Ability to work effectively in a team environment and collaborate with others to achieve common goals. 

Technical Requirements and Skills

• Basic understanding of DNA purification techniques and principles. 
• Good attention to detail and accuracy when performing laboratory tasks. 
• Strong organizational and record-keeping skills to ensure compliance with protocols and maintain lab safety. 
• Ability to communicate effectively, both orally and in writing, to report results and share observations with team members. 
• A proactive and enthusiastic attitude towards learning new techniques and problem-solving in the laboratory. 

Compensation: The is a paid internship. Hourly pay is based on current degree level

• Pursuing Bachelor’s degree: $27.00 per hour
• Pursuing Master’s (MS) degree: $30.00 per hour

Compensation is determined based on verified academic enrollment at the time of hire.

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. 

Job Title: Cell Biology Intern

Location: South San Francisco, CA (local candidates only)

Reports to: Scientist I

Regular/Temporary: Temporary (Summer Internship)

Full/Part-Time (if part-time, number of hours each week): Monday-Friday

Internship Duration (10-12 weeks): Start Date (May/June) – End Date (August/September)

About SonoThera: 

SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.

Program Overview

The Summer Internship Program provides hands-on experience designed to complement academic learning. Over the course of the program, interns will gain exposure to real-world projects, collaborate with cross-functional teams, and receive structured mentorship and feedback. Applicants must be authorized to work in the United States without the need for current or future visa sponsorship.

Role Summary

The Cell Biology Intern will support the Gene Therapy team by contributing to key projects and initiatives. This role offers a unique opportunity to perform cell-based activity assays and to communicate experiment findings with the team. The internship will conclude with a presentation of the intern's findings and contributions. Throughout the internship, the intern will collaborate with team members, participate in team meetings, and assist with assigned deliverables while gaining insight into the broader organization.

Key Responsibilities

• Perform cell-based activity assays for evaluating efficacy of gene therapy drug candidates in a variety of in vitro cell models including immortalized, iPCS-derived, and primary cells. 
• Prepare technical reports and presentations to communicate experimental outcomes to internal teams and senior management. 
• Prepare reagents, maintain laboratory organization, maintain accurate records, and ensure timely completion of routine tasks for high-priority experiments. 

Learning Objectives

By the end of this internship, the Cell Biology intern will:

• Learn various techniques including but not limited to, western blot, cell culture, RT-qPCR, and ELISA
• Analyze samples from in vitro studies 
• Maintain and culture cell lines under aseptic conditions
• Assist in gene expression profiling of cell lines to ensure quality and reproducibility for downstream assays 

Qualifications:

• Currently enrolled in undergraduate or graduate program
• Actively pursuing a science-related degree
• Strong communication skills
• Basic proficiency in Microsoft Office/ other tools

Compensation: The is a paid internship. Hourly pay is based on current degree level

• Pursuing Bachelor’s degree: $27.00 per hour
• Pursuing Master’s (MS) degree: $30.00 per hour

Compensation is determined based on verified academic enrollment at the time of hire.

Equal Opportunity for Diversity & Inclusion  

SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.