Why Join Us?

As a member of the Parabilis Medicines team, you will be a part of an organization dedicated to creating extraordinary medicines for diseases with urgent unmet needs, harnessing our proprietary peptide platform to transform treatment possibilities for patients. Parabilis is a clinical-stage biopharmaceutical company dedicated to unlocking high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities.

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and ARON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

We are seeking an experienced leader in vivarium and in vivo operations to oversee our research animal facilities and in vivo study support. In this Associate Director role, you will be accountable for daily operations, resource planning, budgets, technical training and compliance with IACUC, AAALAC and institutional policies. 

You will manage animal procurement, housing, husbandry services and technicalsupport across discovery and pre‑clinicalstudies, collaborating with program leaders and CRO partnersto align operationalsupport with scientific objectives. A key aspect of this role is developing and coaching a high‑performing technical team while driving operational excellence and continuous improvement to uphold the highest standards of animal welfare.

Key abilities of this role include:

• Provide strategic and operational leadership for vivarium operations, ensuring high-quality husbandry, facility maintenance, and resource planning.
• Serve as institutional lead for IACUC protocols and animal use compliance; prepare and lead facility audits and inspections.
• Oversee procurement and inventory of animals and supplies and maintain accurate records of census and environmental conditions.
• Develop and manage the vivarium operating budget, forecasting resource needs and supporting capital planning. 
• Provide oversight and coordination of in vivo hands on training and SOP adherence for a cross functional group of hybrid scientists; remain willing to perform hands on work as needed and lead the integration of new skills and techniques as our portfolio and programs expand. 
• Coordinate study scheduling and operational support across in vivo pharmacology programs and CRO partners; represent in vivo operations in cross-functional meetings.
• Drive process improvement, SOP development and emergency preparedness; ensure compliance with AAALAC and institutional policies.
• Provide subject matter expertise in in vivo study execution, facility operations, and support program teams by troubleshooting logistics.

What you’ll need to be successful:

• Bachelor’s or master’s degree in biological sciences, animal science or related discipline; 10+ years of vivarium/in vivo experience including 5+ years in a leadership role; advanced degree (M.S., DVM or Ph.D.) and AALAS/CMAR certification are preferred.
• Demonstrated success managing vivarium operations, including budgets, resource forecasting, animal procurement and facility maintenance.
• In depth knowledge of AAALAC and IACUC regulations and experience serving as institutional lead for animal use protocols and facility audits.
• Proven ability to supervise, mentor, and develop technical staff and maintain high standards of animal welfare and safety.
• Strong operational planning, problem-solving and process improvement skills, with experience developing SOPs and emergency plans. 
• Excellent communication and interpersonal skills and ability to collaborate across cross functional program teams and with CRO partners.
• Ability to thrive in a fast paced, collaborative environment, work on site and participate in weekend or holiday coverage as needed.

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $165,000-$200,000, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

Why Join Us?

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. 

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead asset, zolucatetide (FOG-001), is a first-in-class, clinically validated direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in millions of cancer cases annually, including in colorectal cancer, desmoid tumors, hepatocellular carcinoma and a range of other Wnt/β-catenin-driven tumors. In Phase 1 clinical trials, zolucatetide produced the first-ever clinical evidence that it can directly inhibit this interaction, once previously considered “undruggable” despite its role across multiple cancer types. Parabilis is also advancing investigational degraders of ERG and AR^ON into clinical development for the treatment of prostate cancer, as well as progressing other preclinical programs. Backed by a recent $305 million Series F financing, Parabilis is entering an exciting phase of growth and execution.

What’s the opportunity?

The Senior Associate Scientist will play a hands-on role in discovery and translational biology, leading assay development and generating mechanistic insights to support oncology programs from lead optimization through biomarker development. This individual will partner cross-functionally to deliver high-quality, decision-driving data and contribute to advancing novel targets.

• Design, develop, and optimize multiplexed cell-based and high-throughput assays to ensure robust, reproducible, and scalable data generation
• Improve assay throughput and efficiency through automation or semi-automation, proactively identifying risks and refining experimental strategies
• Drive mechanistic understanding of novel oncology targets through hypothesis-driven experimentation (e.g., CRISPR, knockdown, tool compounds, rescue strategies)
• Integrate internal data, literature, and public datasets to inform experimental design, interpret results, and refine scientific hypotheses
• Contribute to biomarker discovery efforts and support translational strategy development
• Collaborate cross-functionally with chemistry, DMPK, in vivo pharmacology, and data science teams to advance programs from hit-to-lead through IND-enabling studies
• Support assay transfer to CROs, including data review, troubleshooting, and performance tracking
• Present findings clearly to project teams and maintain rigorous documentation, including ELN entries and SOP development

What you’ll need to be successful:

• Education & Experience:
  • Bachelor’s degree with 5+ years or Master’s degree with 4+ years of industry experience in a relevant field
  • Experience in discovery biology, with exposure to oncology or related therapeutic areas preferred
• Technical Expertise:
  • Strong hands-on experience developing and executing cell-based and high-throughput assays, including automation
  • Quantitative approach to assay design and data quality (controls, reproducibility, robustness metrics)
  • Experience designing and executing experiments independently and generating actionable insights from complex datasets
  • Familiarity with a subset of the following:
    • CRISPR/Cas9, gene editing/knockdown, overexpression systems
    • qPCR/RT-qPCR, Western blotting, flow cytometry
    • Reporter assays (e.g., luciferase, NanoBRET), protein–protein interaction assays
    • Mammalian cell culture and functional assays (e.g., proliferation, apoptosis)
    • High-throughput screening formats (e.g., 384-well)
    • Omics approaches (e.g., RNA-seq, proteomics) preferred
    • Automation platforms, ELN systems (e.g., Dotmatics), and SOP authorship
  • Core Capabilities:
    • Strong experimental rigor and data-driven decision-making
    • Ability to manage multiple projects and priorities in a fast-paced environment
    • Effective cross-functional collaboration and clear scientific communication
    • Ownership mindset with ability to independently drive workstreams
  • Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovative use of AI is a strong plus
  • Able to work on-site and attend in-person meetings

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary range for this position is $88,000–$108,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.

As an equal opportunity employer, Parabilis Medicines values an inclusive workplace and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive    |     Cambridge, MA 02140    |    www.parabilismed.com

Why Join Us?

Parabilis Medicines is a clinical-stage biopharmaceutical company dedicated to creating extraordinary medicines that unlock high-impact protein targets long-considered undruggable. The company has developed a new class of stabilized, cell-penetrant alpha-helical peptides – Helicons™ – capable of modulating intracellular proteins that are inaccessible to traditional drug modalities. 

Headquartered in Cambridge, Mass., Parabilis is advancing a focused pipeline of multiple first-in-class therapies across both rare and common cancers. Its lead candidate, FOG-001, is the first direct inhibitor of the interaction between β-catenin and the T-cell factor (TCF) family of transcription factors, implicated in colorectal cancer, desmoid tumors, and a range of other Wnt/β-catenin-driven tumors. Parabilis is also advancing investigational degraders of ERG and ARON for the treatment of prostate cancer, as well as other preclinical programs. 

What’s the opportunity?

We are seeking an experienced industry nonclinical pharmacology leader with a demonstrated track record of advancing oncology programs from discovery through IND submission. This role will serve as the nonclinical pharmacology lead on one or more oncology programs, accountable for nonclinical pharmacology strategy, including translational planning and IND-enabling study design, and contributing to regulatory pharmacology content. You will be expected to meaningfully contribute to regulatory filings and identify translational forward approaches that target early clinical development goals.

Your leadership experience and history of working in a highly matrixed cross functional environment will be key in continuing to move oncology programs forward in a collaborative and scientifically rigorous environment. You will work within the existing pharmacology team framework and report directly to the Head of Pharmacology. Success in this role will require excellent communication, scientific thought leadership, a desire to work in a fast paced team environment and an eagerness to grow as a drug hunter.

Key abilities of this role include:

• Lead nonclinical pharmacology strategy for assigned oncology programs from late discovery through IND submission
• Design, oversee, interpret, and communicate in vivo PK/PD and efficacy studies (internally and via CRO partnerships)
• Contribute to IND-enabling study design and author or co-author relevant pharmacology sections of regulatory submissions
• Integrate pharmacology data with DMPK, safety, and biomarker findings to inform development decisions
• Clearly present data and strategy updates to senior leadership and governance teams
• Inspire and mentor junior pharmacology team members

What you’ll need to be successful:

• PhD. in Pharmacology, Biology, or related field with 8+ years post-degree experience with a minimum of 2+ years of program leadership and people management experience
• Experience supporting first-in-class or novel mechanism oncology programs
• Experience working with small molecules, peptides, degraders (e.g., PROTACs), or biologics
• Demonstrated success advancing at least one oncology program to development candidate nomination; experience contributing to an IND submission required
• Strong expertise in in vivo pharmacology, PK/PD modeling concepts, and mechanistic biomarker strategy
• Proven ability to independently design and interpret studies that support program milestones
• Demonstrated ability to utilize AI tools for day-to-day work; baseline proficiency is expected, and advanced or innovated use of AI is a strong plus
• Able to work on-site and attend in-person meetings
• Enthusiastic and innovative mindset with the ability to thrive in a dynamic, fast-pasted, and highly collaborative environment
• Excellent communication, organization, multi-tasking, flexibility, and team skills.

Core Values

Parabilis is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent.We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused.We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In.We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

The base salary target for this position is $165,000 - $200,000 per year, depending on experience, qualifications, and internal practices. Parabilis’s total compensation package also includes an annual target bonus, equity, and a comprehensive suite of competitive benefits designed to support our employees’ overall well-being.