POSITION SUMMARY

Mirum Pharmaceuticals is a rare disease company with a growing portfolio of innovative therapies and a robust pipeline, Mirum is committed to improving the lives of patients who often face limited treatment options and complex care journeys.

We operate with a deep sense of purpose and urgency—grounded in our values: Care. Have Fun. Be Real. Get it Done. As we continue to scale, market access plays a critical role in ensuring that innovation translates into real-world patient access.  The Senior Director of U.S. Market Access will:

• Shape and elevate U.S. market access strategy to drive optimal coverage, pricing, and patient access across the existing portfolio and future assets.
• Lead critical access decisions end-to-end—owning pricing strategy, payer positioning, and execution with a high degree of autonomy.
• Challenge the status quo by introducing differentiated, insight-driven approaches rooted in real-world payer dynamics and behavior.

This role is highly cross-functional and enterprise-facing, partnering across Commercial, Medical, Patient Services (HUB), Government Pricing, Legal/Compliance, and Supply Chain to shape and deliver meaningful access strategies. The ideal candidate blends strategic vision with operational experience, bringing deep payer expertise and a passion for rare disease patients.

JOB FUNCTIONS/RESPONSIBILITIES

• Lead the development of market access strategies that drive coverage expansion, policy optimization, and quality of access (QOA) improvements across commercial and government payers for inline and pipeline assets
• Identify key differentiators critical to payers for rare disease products in competitive environments and translate into actionable strategy
• Anticipate and shape payer dynamics in rare disease to craft clear, differentiated value narratives that resonate in competitive rare disease markets (UM criteria, specialty pharmacy distribution, generics/biosimilar pressure) for both in-line and pipeline assets
• Translate clinical and economic evidence into practical, payer-ready tools that influence coverage and reimbursement decisions
• Lead pre-launch payer engagement, value evidence planning, and access readiness to ensure optimal coverage pathways, especially in competitive markets
• Partner cross-functionally with medical and marketing to ensure evidence generation is targeted, efficient, and directly aligned to access impact.
• Engage directly with payer stakeholders to uncover actionable insights and convert them into strategic access decisions
• Align with the US Head of Payer Accounts on strategic account planning and escalation for high-impact access challenges
• Act as the enterprise voice of access, influencing key decisions across brand strategy, pricing, and commercialization planning workstreams
• Collaborate with Government Pricing on policy implications (e.g., Medicaid best price, 340B, IRA/GUARD considerations)
• Ensure compliance with all regulatory and legal requirements

QUALIFICATIONS

Education /Experience:

• Bachelor’s degree required; MBA or advanced degree preferred
• 10+ years of experience in market access, payer marketing, or reimbursement, with rare disease experience strongly preferred
• Proven success in launching and optimizing access for specialty/rare disease therapies, including pricing strategy
• Deep understanding of:
• Commercial and government payer dynamics
• Prior authorization, appeals, and reimbursement pathways
• Successful experience in leading and developing a team within the market access function  
• Demonstrated ability to lead cross-functional teams and influence senior leadership in small biotech/rare disease companies with agile working environments a plus
• Strong analytical, strategic, and communication skills
• Resilient and adaptable and proven experience in navigating complex payer dynamics with confidence

The salary range for this position is $280,000 to $315,000 USD. Compensation will be determined based on several factors including, but not limited to; skill set, years of experience, and the employee’s geographic location. Please note that the required compensation details listed in US role postings reflect the base salary only, and do not include bonus, equity, or benefits unless otherwise provided.

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POSITION SUMMARY 

The Regional Account Manager, South Central (RAM) is a key field position and will have the opportunity to run their own business within their assigned region. Reporting to the Area Business Director, West, this individual will possess experience in business ownership, leadership, analytics, and the implementation of innovative solutions. The RAM will formulate an effective regional strategy focusing on Geneticist, Endocrinology, and Metabolic Specialist as their core customers.  They will be tasked with establishing short- and long-term business tactics. It will be the responsibility of the RAM to identify key priorities within territories and create and implement business plan that is organizationally approved and fully compliant with all laws. The RAM will be accountable for improving diagnosis rates of all on label indications within their region, growing sales, and effectively partnering across the organization to ensure all goals are met.

The successful RAM will have courage, talent and dedication to seek solutions that can make a meaningful impact within territory or broader team. The ideal candidates are detail orientated, self-structured in their approach to their work, with the ability to manage relationships at all levels. The RAM will have proven presentation and partner management skills and thrive in a rapid paced and dynamic environment within a culture that relies on a patient centric and teamwork orientated approach.

You must reside in one of the following states: OK, West MO, AR, LA, EastTX

JOB FUNCTIONS/RESPONSIBILITIES

• Understands and effectively communicates complex scientific information
• Develops and implements strategic region-level business plans
• Collaborates cross-functionally with internal stakeholders (e.g., Marketing, Market Access, Medical, Operations, Compliance)
• Drives innovative, accountable, and entrepreneurial approaches to business challenges
• Demonstrates strong organizational and time management skills
• Exhibits a strong commitment to customer experience and standards of excellence
• Applies strong business acumen to inform decision-making
• Demonstrates high integrity and adherence to compliance standards
• Demonstrates adaptability and effectiveness in fast-paced, dynamic, and collaborative environments

QUALIFICATIONS

Education/Experience:

• Bachelor’s degree required; MBA or advanced degree preferred
• Minimum of 5+ years of experience in the pharmaceutical/biotech industry, including 3 years of field-based experience in account management, sales, and/or field reimbursement
• Experience in specialty, genetics, or rare disease markets strongly preferred
• Proven success in product launches, ideally with first-in-class therapies and in competitive markets
• Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and access challenges
• Experience working in ambiguous environments requiring cross-specialty coordination for patient identification
• Experience managing a large multi-state geography preferred
• Ability to travel frequently (up to 70% overnight) and maintain a valid driver’s license

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POSITION SUMMARY 

The Regional Account Manager, Ohio Valley (RAM) is a key field position and will have the opportunity to run their own business within their assigned region. Reporting to the Area Business Director, East, this individual will possess experience in business ownership, leadership, analytics, and the implementation of innovative solutions. The RAM will formulate an effective regional strategy focusing on Geneticist, Endocrinology, and Metabolic Specialist as their core customers.  They will be tasked with establishing short- and long-term business tactics. It will be the responsibility of the RAM to identify key priorities within territories and create and implement business plan that is organizationally approved and fully compliant with all laws. The RAM will be accountable for improving diagnosis rates of all on label indications within their region, growing sales, and effectively partnering across the organization to ensure all goals are met.

The successful RAM will have courage, talent and dedication to seek solutions that can make a meaningful impact within territory or broader team. The ideal candidates are detail orientated, self-structured in their approach to their work, with the ability to manage relationships at all levels. The RAM will have proven presentation and partner management skills and thrive in a rapid paced and dynamic environment within a culture that relies on a patient centric and teamwork orientated approach.

You must reside in one of the following states: MI, OH, North IN, WV

JOB FUNCTIONS/RESPONSIBILITIES

• Understands and effectively communicates complex scientific information
• Develops and implements strategic region-level business plans
• Collaborates cross-functionally with internal stakeholders (e.g., Marketing, Market Access, Medical, Operations, Compliance)
• Drives innovative, accountable, and entrepreneurial approaches to business challenges
• Demonstrates strong organizational and time management skills
• Exhibits a strong commitment to customer experience and standards of excellence
• Applies strong business acumen to inform decision-making
• Demonstrates high integrity and adherence to compliance standards
• Demonstrates adaptability and effectiveness in fast-paced, dynamic, and collaborative environments

QUALIFICATIONS

Education/Experience:

• Bachelor’s degree required; MBA or advanced degree preferred
• Minimum of 5+ years of experience in the pharmaceutical/biotech industry, including 3 years of field-based experience in account management, sales, and/or field reimbursement
• Experience in specialty, genetics, or rare disease markets strongly preferred
• Proven success in product launches, ideally with first-in-class therapies and in competitive markets
• Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and access challenges
• Experience working in ambiguous environments requiring cross-specialty coordination for patient identification
• Experience managing a large multi-state geography preferred
• Ability to travel frequently (up to 70% overnight) and maintain a valid driver’s license

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POSITION SUMMARY 

The Regional Account Manager, Mountain West (RAM) is a key field position and will have the opportunity to run their own business within their assigned region. Reporting to the Area Business Director, West, this individual will possess experience in business ownership, leadership, analytics, and the implementation of innovative solutions. The RAM will formulate an effective regional strategy focusing on Geneticist, Endocrinology, and Metabolic Specialist as their core customers.  They will be tasked with establishing short- and long-term business tactics. It will be the responsibility of the RAM to identify key priorities within territories and create and implement business plan that is organizationally approved and fully compliant with all laws. The RAM will be accountable for improving diagnosis rates of all on label indications within their region, growing sales, and effectively partnering across the organization to ensure all goals are met.

The successful RAM will have courage, talent and dedication to seek solutions that can make a meaningful impact within territory or broader team. The ideal candidates are detail orientated, self-structured in their approach to their work, with the ability to manage relationships at all levels. The RAM will have proven presentation and partner management skills and thrive in a rapid paced and dynamic environment within a culture that relies on a patient centric and teamwork orientated approach.

You must reside in one of the following states: CO, ID, MT, WY, KS, SD, ND, NE, AZ, UT

JOB FUNCTIONS/RESPONSIBILITIES

• Understands and effectively communicates complex scientific information
• Develops and implements strategic region-level business plans
• Collaborates cross-functionally with internal stakeholders (e.g., Marketing, Market Access, Medical, Operations, Compliance)
• Drives innovative, accountable, and entrepreneurial approaches to business challenges
• Demonstrates strong organizational and time management skills
• Exhibits a strong commitment to customer experience and standards of excellence
• Applies strong business acumen to inform decision-making
• Demonstrates high integrity and adherence to compliance standards
• Demonstrates adaptability and effectiveness in fast-paced, dynamic, and collaborative environments

QUALIFICATIONS

Education/Experience:

• Bachelor’s degree required; MBA or advanced degree preferred
• Minimum of 5+ years of experience in the pharmaceutical/biotech industry, including 3 years of field-based experience in account management, sales, and/or field reimbursement
• Experience in specialty, genetics, or rare disease markets strongly preferred
• Proven success in product launches, ideally with first-in-class therapies and in competitive markets
• Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and access challenges
• Experience working in ambiguous environments requiring cross-specialty coordination for patient identification
• Experience managing a large multi-state geography preferred
• Ability to travel frequently (up to 70% overnight) and maintain a valid driver’s license

#LI-REMOTE

POSITION SUMMARY 

The Regional Account Manager, Carolinas (RAM) is a key field position and will have the opportunity to run their own business within their assigned region. Reporting to the Area Business Director, East, this individual will possess experience in business ownership, leadership, analytics, and the implementation of innovative solutions. The RAM will formulate an effective regional strategy focusing on Geneticist, Endocrinology, and Metabolic Specialist as their core customers.  They will be tasked with establishing short- and long-term business tactics. It will be the responsibility of the RAM to identify key priorities within territories and create and implement business plan that is organizationally approved and fully compliant with all laws. The RAM will be accountable for improving diagnosis rates of all on label indications within their region, growing sales, and effectively partnering across the organization to ensure all goals are met.

The successful RAM will have courage, talent and dedication to seek solutions that can make a meaningful impact within territory or broader team. The ideal candidates are detail orientated, self-structured in their approach to their work, with the ability to manage relationships at all levels. The RAM will have proven presentation and partner management skills and thrive in a rapid paced and dynamic environment within a culture that relies on a patient centric and teamwork orientated approach.

You must reside in one of the following states: South NC, SC, GA

JOB FUNCTIONS/RESPONSIBILITIES

• Understands and effectively communicates complex scientific information
• Develops and implements strategic region-level business plans
• Collaborates cross-functionally with internal stakeholders (e.g., Marketing, Market Access, Medical, Operations, Compliance)
• Drives innovative, accountable, and entrepreneurial approaches to business challenges
• Demonstrates strong organizational and time management skills
• Exhibits a strong commitment to customer experience and standards of excellence
• Applies strong business acumen to inform decision-making
• Demonstrates high integrity and adherence to compliance standards
• Demonstrates adaptability and effectiveness in fast-paced, dynamic, and collaborative environments

QUALIFICATIONS

Education/Experience:

• Bachelor’s degree required; MBA or advanced degree preferred
• Minimum of 5+ years of experience in the pharmaceutical/biotech industry, including 3 years of field-based experience in account management, sales, and/or field reimbursement
• Experience in specialty, genetics, or rare disease markets strongly preferred
• Proven success in product launches, ideally with first-in-class therapies and in competitive markets
• Experience navigating complex rare disease patient journeys, including diagnosis, referral pathways, and access challenges
• Experience working in ambiguous environments requiring cross-specialty coordination for patient identification
• Experience managing a large multi-state geography preferred
• Ability to travel frequently (up to 70% overnight) and maintain a valid driver’s license

#LI-REMOTE