Company description

Serif Biomedicine is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

The role

We are seeking a highly experienced Lipid Nanoparticle (LNP) Formulation Senior Scientist to lead the design, execution, and interpretation of advanced Design of Experiments (DOE) strategies to drive innovation in next-generation LNP formulations. This role will play a central role in shaping formulation and delivery strategies for nucleic acid therapeutics within a dynamic and collaborative research environment.

The successful candidate will not only develop, optimize, and characterize LNP systems, but also lead the design and establishment of a high-throughput LNP screening platform spanning in vitro systems and small and large animal models. This includes defining experimental frameworks, selecting and implementing appropriate assays, and building scalable workflows to accelerate candidate evaluation and selection.

As a senior scientific contributor, this individual will be expected to operate with a high degree of independence, influence cross-functional program direction, and identify innovative solutions to advance platform capabilities. The role also includes mentoring junior scientists and contributing to the broader scientific strategy through internal leadership and external scientific engagement.

Key responsibilities

• Drive the development, optimization, and implementation of a high-throughput LNP screening platform across small and large animal models, including experimental design, assay selection, and data analysis pipelines.
• Independently define scientific strategies and experimental roadmaps aligned with program goals.
• Serve as a scientific lead for one or more programs, influencing cross-functional decisions across biology, formulation, and translational teams.
• Identify technical gaps and proactively propose innovative solutions to improve platform capabilities and throughput.
• Mentor junior scientists and contribute to building a strong, collaborative scientific culture.
• Communicate findings clearly to internal stakeholders and external partners; contribute to publications, patents, and regulatory documentation.
• Stay at the forefront of LNP delivery technologies and emerging screening methodologies, integrating new approaches where appropriate.

Professional experience and qualifications

• PhD or MS in Chemistry, Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related field and 5+ years of industry experience 
• Proven track record of independently leading research projects and delivering impactful results.
• Demonstrated experience in nanoparticle/LNP design, screening, and in vivo evaluation, preferably including large animal models.
• Experience in developing or scaling high-throughput screening platforms is strongly preferred.
• Strong understanding of experimental design, statistics, and data interpretation.
• Evidence of scientific leadership (e.g., mentoring, leading collaborations, publications, patents).
• Excellent communication and cross-functional collaboration skills.
• Strong hands-on experience with LNP formulations, including formulation development and optimization

What We Offer

• Opportunity to work at the forefront of LNP formulation innovation
• Collaborative, science-driven culture with high impact research
• Competitive compensation and benefits package

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE Change the World list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company annual list of the World Most Innovative Companies. Learn more about Flagship https://url.us.m.mimecastprotect.com/s/xLXBCqxk3LTk9pwcZf3CEkjif?domain=flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

Company Description: 

In today’s healthcare system, disease diagnosis often relies on invasive procedures, such as biopsies, which enable direct interrogation of cellular and tissue health at the suspected source of disease. Due to their invasiveness, cost, and general inconvenience to the patient, biopsies are often conducted after onset of symptomatic disease presenting one of the largest barriers to delivering interventions early in disease progression when they are likely to be most impactful. Flagship Labs 103, Inc. is a privately held early-stage company that is building advanced technological and computational platforms to pioneer the detection of cellular dynamics from minimally invasive biospecimens that can be leveraged to connect individuals to the most effective interventions to prevent onset and progression of disease

Job Description:

We are seeking an experienced and motivated Senior Scientist to join and lead our conjugation efforts to drive FL103’s programs forward. Ideal candidates will be self-motivated, independent, and committed to the generation of high-quality data within a fast-paced and innovative research team. The Conjugation Biochemist will support ongoing bioconjugation projects in several research and development areas.

Essential Responsibilities:

• Design, synthesis, purification and analysis of oligonucleotide-conjugates on antibodies and other modalities. Develop and optimize conjugation protocols using established and novel chemistries and technologies as part of an assay development platform.
• Collaborate closely with the assay development team to guide and optimize conjugates to support FL103’s programs.
• Work as part of a cross-functional team to manage and maintain progress against multiple project timelines, deliver routine updates, and communicate progress to the team.
• Establish and maintain excellent working relationships with critical collaborative partners throughout the company to advance discovery research activities to pre-clinical development.
• Contribute to the preparation of research reports and presentations for internal project teams, leadership team, and external audiences.
• Maintain updated and well-organized lab notebooks and batch records.

Required Qualifications:

• Ph.D. in Biochemistry, Chemistry, or related scientific discipline
• 5+ years of bioconjugation-related industrial experience, preferably in designing, preparing, and validating oligonucleotide conjugates.
• Understanding project timelines and deliverables and plans/coordinate project work accordingly with departmental, functional, and external stakeholders.
• Strong problem-solving skills and a proactive attitude towards exploring new approaches.
• Demonstrates strong written and verbal communication skills, with the ability to clearly present complex scientific data to cross‑functional and senior leadership teams.
• Hands-on expertise with current and cutting-edge bioconjugation techniques for antibodies, proteins, peptides, and other biomolecules.
• Demonstrated hands‑on experience in analytical characterization of conjugates with a strong analytical mindset.  Proficiency in purification techniques such as RP-HPLC, FPLC, SEC, and IEX.
• Able to work independently or in cross-functional team settings with minimal supervision.
• Adaptable and flexible, able to navigate shifting priorities and handle day‑to‑day challenges with professionalism and confidence in fast‑moving environments.
• Self‑motivated with strong interpersonal, organizational, and communication skills, and able to take a hands‑on approach in a dynamic, fast‑paced, and collaborative environment.

About Flagship Pioneering

Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000, Flagship has originated and fostered more than 100 scientific ventures, resulting in more than $90 billion in aggregate value. Many of the companies Flagship has founded have addressed humanity’s most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.  Flagship has been recognized twice on FORTUNE’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies, and has been twice named to Fast Company’s annual list of the World’s Most Innovative Companies. Learn more about Flagship at www.flagshippioneering.com

Flagship Pioneering is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL103 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL103's good faith estimate as of the date of publication and may be modified in the future.

What if… you could pioneer a new approach to designing life’s most essential molecules?

FL116, backed by Flagship Pioneering, is an early-stage biotechnology company transforming the way biomolecules are synthesized. Our innovative platform has the potential to transform how critical research, diagnostic, and therapeutic molecules are manufactured. We are seeking passionate problem solvers ready to make a profound impact on biotechnology and therapeutic innovation.

Position Summary

We are seeking a motivated, detail-oriented, and intellectually curious Research Associate or Senior Research Associate to join our Chemical Biology team. This role is centered on applying chemistry to solve complex biological problems, interrogating and controlling enzyme-driven biomolecular synthesis through a mechanistic and molecular lens.

You will execute high-throughput experiments to probe enzyme–substrate interactions, characterize biomolecule products, and contribute to the development of robust, scalable assays that power our platform. The ideal candidate appreciates the dynamic chemical nature of biological systems and is excited to manipulate and measure biology at the molecular level.

This is an exciting opportunity to build deep expertise at the interface of chemistry and biology within a fast-paced, collaborative startup environment. You are a hands-on experimentalist who thrives in execution-focused, pipeline-driven work and is eager to grow alongside a rapidly evolving technology platform.

Key Responsibilities

• Execute high-throughput experiments to characterize enzyme–substrate and enzyme–product interactions, with a focus on understanding underlying chemical mechanisms
• Apply chemical principles to modulate and interrogate protein function, reactivity, and biomolecular synthesis pathways
• Perform biomolecular product characterization using analytical and separation techniques (e.g., gel electrophoresis, TapeStation, HPLC, plate-based assays)
• Support the development, optimization, and scaling of biochemical and enzymatic assays with an emphasis on quantitative, reproducible readouts
• Generate, analyze, and interpret experimental datasets to extract mechanistic insight and inform pipeline progression
• Collaborate closely with cross-functional teams, including Enzyme Science and Assay Development, to integrate chemical insight into broader platform workflows
• Maintain rigorous experimental documentation and contribute to protocol development and knowledge sharing across the team

Qualifications

• B.S. or M.S. in Chemistry, Chemical Biology, Biochemistry, Biotechnology, or a related discipline with a strong foundation in chemical principles applied to biological systems
• 2+ years of relevant laboratory experience (industry or academic)
• Hands-on experience applying chemistry to biological systems, including enzymatic assays, biomolecule manipulation, or reaction-based workflows
• Strong foundation in protein chemistry, enzymology, or biomolecular interactions
• Proficiency in core laboratory techniques including pipetting, gel electrophoresis, and quantitative assay execution
• Demonstrated ability to generate high-quality, reproducible data and perform rigorous data analysis
• Experience working in fast-paced, collaborative laboratory environments

Preferred Qualifications

• Experience with analytical and separation techniques such as HPLC, capillary electrophoresis, TLC, or plate-based detection systems
• Exposure to bioorthogonal chemistry, chemical modification of biomolecules, or mechanistic enzymology
• Familiarity with nucleic acid or protein characterization platforms (e.g., TapeStation or similar technologies)
• Experience contributing to assay development, optimization, or high-throughput workflows
• Experience preparing samples for NMR
• Familiarity with automation platforms for high throughput screening

Who You Are

Innovative Pioneer: You are excited by the opportunity to explore new scientific frontiers and apply chemical thinking to unlock biological complexity.

Collaborative Contributor: You work effectively across teams, communicate clearly, and value shared success in a highly interdisciplinary environment.

Inventive Problem Solver: You approach challenges with curiosity and creativity, using first-principles thinking to develop elegant experimental solutions.

Mission-Driven Individual: You are motivated by the opportunity to fundamentally change how biomolecules are synthesized and to impact human health and biotechnology.

Motivated Learner & Emerging Professional: You are eager to deepen your expertise in chemical biology, take ownership of your work, and grow into a highly capable scientist within a startup environment.

Values and Behaviors:

Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $81,000 - $107,250. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL116 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL116's good faith estimate as of the date of publication and may be modified in the future.

Company description

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases. It was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

The role

We are seeking a motivated Associate Scientist to support the development, preparation, and characterization of Lipid Nanoparticle (LNP) formulations. This role is highly hands-on and focused on formulating, screening, and analyzing LNPs to support discovery and development programs. The ideal candidate works well in a fast-paced, team-oriented environment and is eager to deepen their expertise in formulation science.

Key responsibilities

• Prepare and formulate LNPs using established protocols and evolving methods
• Execute formulation experiments to support optimization and screening efforts
• Perform LNP characterization and analytics, including particle size, PDI, encapsulation efficiency, and stability testing
• Accurately document experimental procedures, results, and observations in laboratory records
• Analyze and summarize experimental data and communicate findings to project teams
• Collaborate closely with scientists across formulation, analytics, and biology functions
• Support routine laboratory operations, including reagent preparation, equipment upkeep, and inventory management

Professional experience and qualifications

• BS or MS in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, or a related field and 8+ years of industry experience
• Hands-on experience with LNP formulations or lipid-based delivery systems
• Familiarity with LNP analytical techniques (e.g., DLS, encapsulation assays, basic stability studies)
• Strong attention to detail and ability to follow experimental protocols
• Ability to work effectively as part of a team in a fast-paced environment
• Good written and verbal communication skills

What We Offer

• Opportunity to work at the forefront of LNP formulation innovation
• Collaborative, science-driven culture with high impact research
• Competitive compensation and benefits package

LOCATION: Cambridge, MA

ABOUT FLAGSHIP PIONEERING

Flagship Pioneering invents and builds platform companies, each with the potential for multiple products that transform human health, sustainability and beyond. Since its launch in 2000, Flagship has originated more than 100 companies. Many of these companies have addressed humanity most urgent challenges: vaccinating billions of people against COVID-19, curing intractable diseases, improving human health, preempting illness, and feeding the world by improving the resiliency and sustainability of agriculture.

Flagship has been recognized twice on FORTUNE Change the World list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Company annual list of the World Most Innovative Companies. Learn more about Flagship https://url.us.m.mimecastprotect.com/s/xLXBCqxk3LTk9pwcZf3CEkjif?domain=flagshippioneering.com.

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $96,000 - $126,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on Serif Biomedicine's good faith estimate as of the date of publication and may be modified in the future.