An affiliate of Colossal is seeking a Laboratory Operations Associate to support the day to day operations of the lab according to established procedures. The primary role of the Laboratory Operations Associate is to monitor performance of all tasks and materials required to ensure that maintenance of equipment and consumables inventory meets all lab operations requirements. In this hands-on position, the Lab Operations Associate will be a proactive, self-directed contributor, building their expertise in laboratory operations within a leading-edge biotechnology facility. This position reports directly to the Associate Director of Lab Operations.

This new position is based on-site out of our Dallas, TX Headquarters. 

Duties and Responsibilities:

• Receive and log in shipments, ensuring proper unpacking, documentation, box breakdown, and placement of items in designated storage locations.
• Assist with delivery and pickup of lab compressed gases and cryogenic liquids. 
• Assist with liquid/solid waste pickups and proper storage of chemical/biohazard waste. 
• Perform glassware/washing/autoclave services and preparation of buffer/media stocks.
• Assist with ordering general laboratory supplies, reagents and consumables.
• Support laboratory and facility equipment management – assist with delivery, installation, calibrations, preventative maintenance, cleaning, and decontamination of laboratory equipment; ensure proper use, care, and training of equipment by employees; help develop, implement, and maintain standard operating procedures for equipment use and care.
• Assist with all site-related safety programs in line with corporate EHS policies, including hazardous waste streams, chemical inventories and SDS databases.
• Assist in the maintenance and servicing of laboratory equipment including daily tasks to ensure instruments are working properly, schedule preventative maintenance, troubleshoot routine issues.  
• Act as a point of contact for lab-related service vendors and contractors including stockroom inventory, lab coat laundering, pipette management.
• Support general lab activities along with the operations team to promote an efficient working environment.
• Perform other duties as assigned in conjunction with the Laboratory Operations team.

Required Skills and Abilities:

• Experience with biological instrumentation.
• Hands-on experience in biology or chemistry.
• Familiarity with cellular, molecular, and microbiology techniques.
• Outstanding organizational skills and ability to prioritize multiple tasks and/or projects, inventory management and ordering. 
• Customer service oriented; works well with internal and external stakeholders.
• Demonstrated skill in problem-solving and the ability to handle operations issues in a fast-paced environment with a service-focused attitude.
• Detail oriented with specific attention to quality control and a commitment to excellence.
• Personable and articulate, with strong written and verbal communication skills. 
• Desire to be part of a team-focused environment. 
• Proficient in Microsoft Office, Google Workspace applications.
• Occasional early morning, evening and/or weekend hours may be a requirement. 
• Must be able to lift up to 50 pounds and be able to stand for multiple hours at a time. 
• Ability to travel to other laboratory locations, as needed. 

Education and Experience:

• Associate Degree with minimum of two years experience OR a Bachelor’s Degree in science field with minimum one year experience in an academic and/or commercial laboratory environment.
• Experience in equipment cleaning and maintenance, biological and chemical waste management. inventory management and ordering. 

An affiliate of Colossal is seeking a Developmental Biologist that will work to design and conduct experiments that will inform genetic engineering for avian de-extinction projects. Leveraging their expertise in genetics and developmental biology, they will work closely with bioinformaticians to identify genetic variants of interest and test the effect of those variants in an embryonic avian model.

**This position is based out of Dallas, TX. Relocation assistance is available**

Duties and Responsibilities:

• Maintain expertise and familiarity with genetics and development literature 
• Work closely with the bioinformatics team to identify genetic variants of interest
• Perform in ovo electroporations and manipulations on avian embryos
• Process, image, and analyze avian embryos of various stages using techniques such as fluorescent microscopy, whole mount skeletal staining and morphometrics
• Design, develop, and implement novel experiments, techniques, procedures, protocols, and systems in line with research program objectives for non-model birds
• Contribute to, and be responsible for, documentation, reports, presentations and publications associated with work 

Skills and Abilities:

• Experience with avian embryo manipulation, such as in ovo electroporation or embryonic tissue transplantation, OR relevant experience in other embryonic systems
• Strong working knowledge of gene regulatory networks in embryonic development
• Strong working knowledge of research methodology and study design; hypothesis testing; qualitative and quantitative data interpretation and application
• Exceptional verbal and written communication skills
• Demonstrated ability to take the initiative to move projects forward, make independent judgments, maintain accurate lab data, clearly understand and respond to experimental results, while communicating effectively 
• Ability to work independently and collaboratively, as required, in a fast-paced, matrixed, team environment consisting of internal and external team members
• Analytical and creative thinker with excellent problem-solving skills and the ability to prioritize own work and adapt to changing team priorities
• Excellent planning, organization and time management skills 
• Very high level of comfort with productivity and communication software platforms (MS Office, GSuite, Slack, digital notebooks, project management systems, etc.)

Qualifications:

• DVM/PHD in developmental biology, biological sciences, veterinary medicine, bioengineering, molecular biology, genetics, or any science related field is required
• 2+ years of experience in developmental biology strongly preferred
• 2+ years of experience working with avian eggs and embryos strongly preferred

An affiliate of Colossal is seeking a motivated and detail-oriented Research Associate to join our interdisciplinary team at the intersection of molecular and developmental biology. This role offers the opportunity to work closely with scientists developing cutting-edge approaches to drive novel applications in the modification of phenotypes in avians. The ideal candidate will bring strong technical skills in molecular biology, excellent problem-solving abilities, and a collaborative mindset to help drive innovation in species de-extinction and conservation.

This position is based in Dallas, TX. Relocation assistance is available. 

Duties and Responsibilities

• Collaborate with developmental biologists to analyze gene expression and function across different developmental stages.
• Perform molecular cloning, construct design, and plasmid preparation to support the development team.
• Screen constructs in developing avian embryos to quantify expression patterns. 
• Produce transfection reagents to aid experimental workflows.
• Analyze and interpret experimental data, providing recommendations to guide project direction.
• Participate in meetings, generate reports, and present findings to ensure alignment with project milestones.
• Maintain accurate, detailed laboratory records and demonstrate strong organizational skills.

Required Skills and Qualifications

• Hands-on experience in molecular cloning, plasmid construction, and plasmid preparation (mini-, midi-, and maxi-prep).
• Skilled in PCR primer design and PCR optimization/troubleshooting.
• Strong organizational skills with the ability to manage multiple projects simultaneously and meet deadlines.
• Excellent written and oral communication skills, with demonstrated problem-solving abilities.
• Bachelor’s degree (B.S./B.A.) in molecular biology, or a related life science field with 1 or more years of hands-on research experience in industry or academic research labs.

Preferred Skills and Abilities

• Experience handling vertebrate embryos. 
• Experience with transfection reagents (i.e. lipofectamine or electroporation) 
• Experience with synthesis and packaging of mRNA
• Familiarity with high-throughput automation platforms for molecular biology workflows.

The Research Associate provides hands-on experimental support for base editing workflows (ABE/CBE) across genome engineering programs. This role is responsible for executing experiments, generating high-quality data, and supporting workflow optimization within the Genome Engineering Technology (GET) team. The position works closely with the Base Editing Manager and cross-functional partners to advance genome editing strategies for species restoration. This is an individual contributor role that reports to the Base Editing Manager.

This position will be based on-site in Dallas, TX. Relocation assistance is available. 

Duties and Responsibilities:

• Execute base editing experiments (ABE, CBE) in mammalian cell systems
• Perform cell culture, including transfection, passaging, and cryopreservation
• Prepare and handle base editing reagents, including guides and plasmids
• Conduct nucleic acid extractions and downstream editing outcome analyses (e.g., PCR, sequencing, flow cytometry)
• Support optimization of editing efficiency, specificity, and delivery methods
• Maintain accurate experimental records in Benchling (ELN)
• Assist with reagent inventory management and lab organization
• Collaborate with genome engineering teams to support project execution
• Troubleshoot experimental workflows and contribute to protocol improvements

Required Skills and Abilities:

• Experience with mammalian cell culture and cell-based assays
• Proficiency in molecular biology techniques (PCR, DNA/RNA handling, cloning)
• Familiarity with genome editing technologies (CRISPR, base editing preferred)
• Experience with flow cytometry or cell characterization methods is a plus
• Strong attention to detail and commitment to high-quality documentation
• Ability to manage multiple priorities and work in a fast-paced environment
• Strong communication and collaboration skills

Education and Experience:

• Bachelor’s or Master’s degree in Molecular Biology, Genetics, Bioengineering, or related field
• 1 or more years of relevant laboratory experience (industry or academic)
• Hands-on experience with cell culture and molecular biology required

Colossal Biosciences is seeking an experienced Clinical Veterinarian to help build and lead clinical veterinary operations across a rapidly expanding portfolio of animal programs. This role is designed for a veterinarian who thrives in a start-up environment and is excited not only to deliver exceptional clinical care, but also to design, implement, and operationalize the systems, protocols, and facilities that underpin a world-class animal health program.

The Clinical Veterinarian will provide comprehensive medical oversight for a wide variety of species, including restored species, and will play a foundational role in shaping Colossal’s long-term animal health infrastructure. This position requires strong expertise in anesthesia, surgery, emergency response, preventative medicine, and clinical systems development, along with the ability to build scalable veterinary programs in a dynamic and evolving organization.

This position reports directly to the Chief Animal Officer. Strong preference for the individual to be based on-site in Dallas, TX.

Key Responsibilities:

 Clinical Veterinary Care & Case Leadership

• Provide comprehensive medical care across a diverse portfolio of species, including restored species.
• Perform physical examinations, diagnostic evaluations, and therapeutic interventions.
• Develop case management plans for acute, chronic, and emergent conditions.
• Lead emergency and critical care response as needed, including field-based situations.
• Maintain accurate and compliant medical records within established record-keeping systems.
• Develop and oversee preventative medicine programs and whole-population health strategies.

Anesthesia & Surgical Leadership

• Design and implement anesthetic protocols for a wide variety of species in both hospital and field environments.
• Perform and oversee sedation, induction, monitoring, and recovery.
• Operate and maintain modern anesthesia delivery and physiologic monitoring systems.
• Perform surgical procedures as appropriate to program needs.

• Establish anesthetic safety guidelines, drug formularies, and controlled substance management systems.
• Develop contingency protocols for complex or high-risk immobilizations.
• Deep experience in advanced anesthesia and peri-operative care is essential.

Program & Protocol Development (Startup Environment)

This position requires building clinical systems from the ground up. Responsibilities include:

• Designing and implementing clinical SOPs for:
• Preventative medicine
• Quarantine and biosecurity
• Anesthesia and surgical standards
• Controlled drug management
• Emergency response
• Necropsy and pathology workflows
• Establishing pharmaceutical inventory systems and DEA-compliant tracking protocols.
• Advising on veterinary hospital and clinical facility design, equipment selection, and operational workflow.
• Supporting construction planning and activation of new animal facilities.
• Creating scalable veterinary infrastructure to support program growth and species expansion.

The Clinical Veterinarian must be comfortable operating in ambiguity and transforming early-stage operations into structured, high-functioning clinical systems.

Animal Welfare, Biosecurity & Regulatory Compliance

• Lead implementation of quarantine protocols and health certification processes.
• Oversee animal transfer evaluations and regulatory documentation.
• Ensure compliance with USDA, DEA, and applicable federal and state regulations.
• Develop and monitor biosecurity and zoonotic disease prevention protocols.
• Partner with animal care teams on welfare assessments and behavioral health considerations.
• Support necropsy procedures and diagnostic sample management.

Cross-Functional Collaboration

• Partner closely with the Chief Animal Officer on strategic planning and clinical priorities.
• Collaborate with animal husbandry, research, genetics, and facilities teams.
• Coordinate with external veterinary specialists and consultants as required.
• Contribute veterinary expertise to research initiatives requiring anesthesia, sampling, or surgical intervention.
• Help establish clinical best practices that align with both conservation and research objectives.

Emergency Preparedness & Field Operations

• Be available for regular coverage during all hours including weekends and holidays
• Develop and implement emergency preparedness protocols.
• Support veterinary interventions in large-acreage and field environments.
• Lead clinical oversight during immobilizations and remote procedures.

Required Skills and Abilities:

• Entrepreneurial mindset with comfort building systems in a growth-stage organization.
• Exceptional clinical judgment and attention to detail.
• Strong organizational and protocol development capabilities.
• Clear communicator able to collaborate across scientific and operational teams.
• High emotional intelligence and ability to work within interdisciplinary environments.
• Adaptable and resilient in fast-paced, mission-driven settings.
• Familiarity with research animal oversight and regulatory frameworks.
• Experience providing medical care across a wide variety of species.
• DEA licensure (or ability to obtain).
• Strong emergency and critical care capabilities.
• Proven ability to operate independently and make sound clinical decisions in dynamic environments.
• Extensive domestic travel with some international travel (~30%)

Preferred Skills and Abilities:

• Experience in zoological, wildlife, or conservation medicine settings.
• Experience supporting novel or complex species programs.
• Experience standing up or scaling a veterinary program.
• Board certification or advanced specialty training.

Education and Experience:

• DVM or VMD from an AVMA-accredited institution.
• Minimum 10 years of exotic clinical veterinary experience.
• Demonstrated expertise in advanced anesthesia and surgical techniques.

Colossal is a breakthrough bioscience and genetic engineering company that builds radical new technologies to advance the field of genomics. Colossal creates disruptive technologies for extinct species restoration, critically endangered species protection/conservation and the repopulation of critical ecosystems that support the continuation of life on Earth.

Interested in joining us in a full-time role but there are no jobs posted that match your background and/or interest? Apply here to join our Colossal Talent Community!

Some things to know:

• After the application confirmation email gets to you, we will only reach out if/when a new role opens up that aligns to your qualifications.
• Our positions are currently located on-site in Dallas, TX.
• All applicants must be authorized to work in the United States to be eligible for hire. 
• The majority of our roles are in the biological sciences and engineering. We also hire in animal care as well as all corporate functions such as finance, human resources, information technology, legal, marketing, and operations.

In the meantime, keep an eye on our Careers Website for new job opportunities!

• Learn more about what we do and why we do it at: https://colossal.com/ 
• Learn about the de-extinction of the Woolly Mammoth here: https://colossal.com/mammoth/
• Learn about the de-extinction of the Thylacine (Tasmanian Tiger) here: https://colossal.com/thylacine/
• Learn about the de-extinction of the Dodo Bird here: https://colossal.com/dodo/
• Learn about the de-extinction of the Dire Wolf here: https://colossal.com/direwolf/
• Learn about the exciting science happening in our labs here: https://colossal.com/technology/
• Learn about our amazing conservation work here: https://colossal.com/conservation/
• Check out our page on de-extinction here: https://colossal.com/de-extinction/