The Team

The Biohub in New York is an independent nonprofit research institute that brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine. Biohub itself supports some of the brightest, boldest engineers, data scientists, and biomedical researchers to investigate the fundamental mechanisms underlying disease and develop new technologies that will lead to actionable diagnostics and effective therapies. We are guided by our values of scholarly excellence; disruptive innovation; hands-on engineering/hacking/building; partnership and collaboration; open communication and respect; inclusiveness; and opportunity for all.

Our Vision                                                                     

• We pursue large scientific challenges that cannot be pursued in conventional environments
• We enable individual investigators to pursue their riskiest and most innovative ideas
• The technologies developed at Biohub facilitate research by scientists and clinicians at our home institutions and beyond

Diversity of thought, ideas, and perspectives are at the heart of Biohub and enable disruptive innovation and scholarly excellence. We are committed to cultivating an organization where all colleagues feel inspired and know their work makes an important contribution.

The Opportunity

The Biohub is seeking a skilled and motivated Research Associate to support innovative investigations into spatial architecture of molecular systems and its role in controlling cell state dynamics. In our newly established Synthetic Spatial Omics Laboratory, we advance next-generation spatial multi-omics platforms for understanding how cells process combinatorial signals, designing synthetic biology toolkits, and capturing cellular temporal histories with spatial resolution.

The successful candidate will contribute to projects integrating spatial multi-omics and synthetic biology to investigate molecular neighborhood reorganization in response to perturbations, engineer programmable cellular functions, and identify the molecular drivers of cell state transitions. This position offers the opportunity to develop expertise at the intersection of technology development and fundamental discovery in a highly collaborative, interdisciplinary research environment. 

What You'll Do

• Perform imaging-based multi-omics experiments (e.g., seqFISH and related approaches) to map subcellular molecular organization and cell state transitions.
• Carry out perturbation experiments to decode how molecular neighborhoods respond to combinatorial signals.
• Assist in engineering and characterizing synthetic biology systems using spatial multi-omics approaches.
• Support data processing and analysis using established computational workflows. 
• Collaborate with team members across experimental and computational disciplines.
• Contribute to preprints, publications, presentations, and open science practices as part of the research team.

What You'll Bring

• Bachelor’s or Master’s degree in Molecular Biology, Cell Biology, Biochemistry, Bioengineering or a closely related discipline.
• 1-2+ years of hands-on research experience in an academic and/or industry laboratory setting.
• Solid foundation in molecular biology techniques, including cell culture, nucleic acid workflows, and cellular functional assays.
• Working proficiency in Python, R, or comparable languages for the analysis of imaging and sequencing data.
• Strong organizational skills, attention to detail, and commitment to maintaining thorough experimental records.
• Ability to work both independently and collaboratively in a team-oriented research environment.
• Enthusiasm for learning new techniques and contributing to cutting-edge research.

Compensation

The New York City, NY  base pay range for a new hire in this role is $71,000.00 - $89,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Hybrid #LI-Onsite

The Team

Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here. 

Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine.

Our Vision

• Pursue large scientific challenges that cannot be pursued in conventional environments
• Enable individual investigators to pursue their riskiest and most innovative ideas
• Facilitate research by scientists and clinicians at our home institutions and beyond

We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.

The Laboratory of Immunogenomics at CZ Biohub NY (www.mahatlab.com) studies the non-coding regulatory genome to understand and address immune dysfunction in diseases like cancer, autoimmune disorders, and aging. We focus on enhancers—non-coding, highly cell–type–specific transcriptional regulatory elements—and their role in shaping immune responses.

We develop and utilize genomic technologies, including bulk and single-cell nascent RNA sequencing, genome editing, immune engineering, and CRISPR-based functional screens in patient biopsies, organoid systems, and mouse models. Through computational analysis integrating machine learning and AI, we map enhancer–gene networks and identify disease-driving elements. Our goal is to advanc

The Opportunity

We seek a Postdoctoral Fellow to investigate how transcription factors regulate gene expression programs in cancer and how disease-associated mutations in transcription factors disrupt these programs to drive malignant phenotypes. Many cancer-linked alterations affect transcription factor binding, chromatin engagement, and transcriptional output, yet the downstream regulatory mechanisms and disease consequences remain incompletely understood. This project aims to define the molecular functions of transcription factors in normal and diseased states, map how mutations alter chromatin and transcriptional regulation, and utilize machine learning to predict and test novel mutant-TF-specific functions.

What You'll Do

Transcription Factor Mechanism Discovery

-   Define how transcription factors control gene expression, chromatin accessibility, and regulatory element activity in cancer-relevant cellular contexts.

-   Map transcription factor occupancy, chromatin state, and nascent transcription using GRO-seq/ PRO-seq, CUT&RUN, ATAC-seq, DNA methylation profiling.

-   Integrate transcription factor binding data with enhancer activity, promoter usage, and transcriptional outputs to identify direct regulatory targets and core gene networks.

-   Apply CRISPR editing to test candidate genes, regulatory elements, and pathways.

Mutation-Driven Regulatory Analysis

-   Determine how cancer-associated mutations in transcription factors alter DNA binding, cofactor recruitment, chromatin remodeling, and transcriptional control.

-   Compare wild-type and mutant transcription factor function across genomic, epigenomic, and transcriptional assays to identify mutation-specific regulatory defects.

-   Characterize the mutated-TF-associated co-factors, transcription factor, chromatin remodeling through protein-protein interactions.

-   Dissect how these changes impact oncogenic pathways, lineage identity, cellular plasticity, and disease progression.

AI/ML-Guided Functional Discovery

-   Collaborate closely with AI/ML scientists to apply protein language models and related computational approaches to transcription factors and their disease-associated variants.

-   Use these models to predict potential novel molecular functions, protein-protein interaction partners, and mutation-associated cellular phenotypes.

-   Design and execute experimental strategies to test model-derived predictions in laboratory settings, using genomic, molecular, and functional assays to validate predicted mechanisms and disease-relevant consequences.

-   Help establish an iterative framework in which computational predictions inform experiments, and experimental results refine downstream modeling and hypothesis generation.

Genomic Library Preparation

-   Lead and optimize genomic library preparation workflows for chromatin and transcription-focused assays, with strong emphasis on GRO-seq/PRO-seq, CUT&RUN, ATAC-seq, DNA methylation assays, and RNA-seq.

-   Generate high-quality sequencing libraries from cell lines, engineered models, and primary samples, ensuring rigorous experimental design, QC, and reproducibility.

-   Support comparative profiling across perturbation conditions, mutant backgrounds, and treatment states to reveal context-specific transcription factor biology.

Molecular and Cell Biology Validation

-   Perform core molecular biology methods, including tissue culture, organoid and patient sample processing, ChIP, gel electrophoresis, cloning, FACS, and ELISA etc., to validate mechanistic hypotheses.

-   Use genome engineering and perturbation approaches, including CRISPR-based editing and CRISPR screening, to test the functional consequences of transcription factor mutations and candidate regulatory dependencies.

-   Validate key findings through orthogonal assays in relevant cellular models.

Pathway Integration and Disease Modeling

-   Identify critical downstream effectors, co-factors, and candidate therapeutic vulnerabilities emerging from mutant transcription factor activity.

-   Contribute to the development of mechanistic frameworks explaining how transcription factor dysfunction gives rise to disease.

What You'll Bring

Essential 

• PhD in Molecular Biology, Cancer Biology, Genetics, Genomics, or a related field.
  Strong hands-on experience in genomic library preparation, particularly for chromatin and transcription-focused assays such as GRO-seq/PRO-seq, CUT&RUN, ATAC-seq, DNA methylation profiling.
• Expertise in basic molecular biology techniques, mammalian cell culture, engineered cell models, and/or primary samples.
• Experience with functional perturbation methods such as CRISPR editing, CRISPR screening, or other genetic manipulation approaches.
• Demonstrated work and publication in transcription factor biology, gene regulation, epigenomics, or cancer mechanisms, reflecting independent experimental work and mechanistic biological insight.

Preferred

• Familiarity with computational biology methods and genomic data analyses.
• Experience studying transcription factors, chromatin regulators, or gene regulatory mechanisms in cancer or other disease contexts.
• Familiarity with comparing wild-type and mutant protein function using genomic and molecular assays.
• Interest in collaborative, interdisciplinary research at the interface of transcription, epigenetics, and disease biology.

Compensation

The New York, NY base pay for a new hire in this role is Postdoctoral Fellow = $93,000.00. This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Onsite

The Team

Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research ev

Our Immune Cell Reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here. 

Our work brings together three powerhouse universities - Columbia University, The Rockefeller University, and Yale University - into a single collaborative technology and discovery engine.

Our Vision

• Pursue large scientific challenges that cannot be pursued in conventional environments
• Enable individual investigators to pursue their riskiest and most innovative ideas
• Facilitate research by scientists and clinicians at our home institutions and beyond

We are a team of passionate individuals powered by technology, guided by scientific research, and driven by collaboration, working toward a mission to cure or prevent all disease.

The Opportunity

We are seeking a highly motivated Postdoctoral Fellow to lead development of pooled functional genomics technologies at scale, with emphasis on CRISPR technologies (CRISPRi, CRISPRa, CRISPRoff, and CRISPR base editing) in iPSC-derived immune cells and primary immune cells.

The role involves designing, optimizing, and validating new pooled CRISPR workflows and driving projects that provide new insights for immune system reprogramming and training foundational AI models. This position offers the opportunity to develop and own an independent research project—with potential to publish and present findings—while contributing to the team's broader collaborative efforts.

This is a wet lab-based, hands-on position that specifically requires experience with functional genomics method development and high-volume human cell culture. It offers the opportunity to develop and implement assays, conduct perturbation experiments, oversee data generation, and participate in follow-up discovery collaborations.

This role is ideal for a recent PhD with a proven track record in functional genomics and human cell culture (particularly iPSC culture) who excels at multitasking genomics projects and developing cutting-edge CRISPR genomics technologies. You will join a highly collaborative team at the forefront of massive-scale perturbation technologies and AI model development to predict how to reprogram the immune system to prevent, identify, and treat human disease.

This researcher will be based at our Satellite site in NYC integrated with a team specializing in advanced functional genomics technologies, particularly massive-scale pooled CRISPR screens and single-cell profiling, to understand immune cell regulation. The team sits at the intersection of next-generation wet-lab genomics technologies and AI model development.

What You'll Do

Essential 

• Massive-scale Perturb-seq: Design, optimize, scale, and carry out large-scale Perturb-seq experiments in iPSC-derived immune cells and immortalized cell lines.
• Assay development: Design, optimize, and validate CRISPR functional genomics technologies to obtain higher quality, more complex data about cell-state regulation in human cells.
• Immune cell engineering: Culture and differentiate iPSCs into immune cell types such as T-cells and macrophages.
• Data generation: Partner with AI researchers to process and interpret large-scale single-cell datasets.
• Collaboration and dissemination: Collaborate across disciplines to understand systems-level reprogramming of human immune cells.

Nice to have - 

• Experience with CRISPR screening in iPSCs and primary immune cells.
• Experience analyzing large-scale genomics datasets.
• Working knowledge of R or Python and single-cell analysis tools.
• Experience with cytokine or small molecule immune cell assays.

What You'll Bring

• PhD in molecular biology, systems biology, genetics, biomedical engineering, or related field
• Proven expertise and demonstrated success in large-scale functional genomics assays and method development
• Experience designing and executing pooled CRISPR screens and/or compound perturbation assays
• Excellent communication skills and proven ability to work in a collaborative team environment
• Ability to independently design rigorous experiments, troubleshoot complex workflows, and drive projects to completion.
• Collaborative mindset and strong scientific communication skills.

Compensation

The New York City, NY base pay range for a new hire in this role is $93,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Hybrid #LI-Onsite

The Team

The Opportunity

The Biohub invites exceptional scientists to apply for a Group Leader (Principal Investigator-equivalent) position. We seek researchers who pursue fundamental questions in immunology, including—though not limited to—experts in systems immunology, immune engineering, and functional or molecular immunology, with a particular emphasis on cellular subtypes associated with immune regulation in cancer and/or neuroinflammation. Ideal candidates will aim to uncover the core principles and dynamic behaviors that govern immune system function in both health and disease. We especially welcome applicants who integrate quantitative, high-throughput, and systems approaches to address broad immunological questions and principles, rather than those focused primarily on tool or method development. The overarching mission is to reveal the fundamental principles governing the function and development of the human immune system, including via regulatory, signaling, and cell-cell molecular interaction network analysis. The goal will be to identify mechanisms that can help reprogram the immune system’s function to monitor organ specific health conditions, modulate cell trafficking, and restore normal immune function in human disease conditions.

The Biohub in New York fosters a vibrant environment where fundamental discovery and cross-disciplinary collaboration are encouraged. We particularly welcome scientists eager to collaborate across biology, computation, and engineering to generate transformative insights into immune biology. The successful candidate will join a highly collaborative environment of both intramural investigators at the Biohub network and extramural investigators at our partner institutes, Columbia University, Yale University and The Rockefeller University. The successful candidate will have access to world-class resources within the Biohub and across partner campuses. Candidates are expected to establish an independent, creative and innovative research program, as well as demonstrate a commitment to collaboration. The Biohub will offer a competitive package with full funding for research personnel, lab operational costs, and essential equipment.

Applicants must hold a Ph.D., M.D., or equivalent degree in immunology or a related field, and have a strong foundation in quantitative or mechanistic approaches to biological research. Applicants should have a record of at least five years of postdoctoral or equivalent research experience demonstrating creativity, independence, and impactful contributions in research aligned with the themes described above.

Applicants are required to provide a cover letter and a 3-page research statement.

What You'll Do

• Lead an innovative, rigorous, and highly collaborative research program aligned with the mission of Biohub, focused on advancing fundamental understanding of the immune system.
• Develop a transformative research vision and provide technical guidance and mentorship to team members.
• Play a key role in our collaborative efforts to engineer immune cells to detect, prevent, and cure organ-specific diseased states by leveraging your expertise in immunology.
• Engage with colleagues throughout the Biohub to uphold our values of scholarly excellence, innovation, open communication, collaboration, partnership, and opportunity.
• Communicate progress and results with colleagues and the leadership team.
• Publish and disseminate impactful findings and the products of your research as preprints (medRxiv, bioRxiv) and/or software repositories (e.g., GitHub).
• Collaborate with the Biohub team to patent and license technologies resulting from your research.

What You'll Bring

• PhD or MD or equivalent degree in immunology or a related field.
• A minimum of 5 years post-doctoral experience with a strong foundation in immunology.
• An innovative research plan aimed at revealing the fundamental principles that govern the immune system. 
• Demonstrated publication track record in top tier journals on topics related to the scientific goals of this position.
• Demonstrated leadership, track record of innovation, and ability to work collaboratively.
• Supervisory or mentoring experience is a plus but not required for early-career applicants, but expected for more senior candidates.
• Demonstrating a creative vision to establish a highly innovative and impactful research program.
• Outstanding interpersonal and communication skills.
• Demonstrated commitment to open science and highly aligned with the mission and values of Biohub.

Compensation

The New York City, NY base pay range for a new hire in this role is $153,000.00 - $185,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

Interviews will begin starting April 15th 2026 and will continue until the position has been filled.

#LI-Hybrid 

The Team

Our immune cell reprogramming team integrates foundational research on immunology and disease biology with AI-modeling to develop engineered cells that harness our own immune system to detect and treat early signs of age-related diseases, like cancer, Alzheimer’s, and Parkinson’s. These technologies will enable precise, context-dependent therapeutic responses only when and where it is needed. You can learn more about our work here. 

The Opportunity

Biohub NY seeks to recruit an outstanding scientist to serve as Group Leader (equivalent to a Principal Investigator in academia), leading our Immune Cell Reprogramming research program.

The Group Leader will build, lead, and oversee a small research team focused on elucidating immune cell mechanisms in disease at the cellular and molecular levels, with the ultimate goal of developing novel immunotherapies. The program should include a strong research emphasis on T cell exhaustion, including strategies to understand, prevent, and/or reverse this process.

The successful candidate will join a vibrant, deeply interdisciplinary community of scientists working at the intersection of immunology, cell engineering, and translational medicine—representing one of the largest and most collaborative ecosystems of its kind.

Ideal candidates will demonstrate a strong track record of scientific achievement, along with a commitment to collaboration in a highly interdisciplinary environment.

Applicants are required to provide a cover letter and a 3-page research statement.

What You'll Do

• Identify, recruit, manage and mentor cell reprogramming lab members working under his/her supervision.
• Lead and actively participate in an innovative, vigorous, and collaborative research program aligned with the mission of CZ Biohub NY with the goal of elucidating the molecular and cellular mechanisms underlying cellular changes in chronic infection, cancer, or aging. 
• Play a collaborative role in our collective efforts to bioengineer immune cells for the detection and prevention of diseased states both within the Biohub NY and across the ecosystem of Biohubs and CZI activities. 
• Demonstrating outstanding productivity based on a compelling record of scientific publication, collaboration, and IP generation.
• Play a collaborative role in our collective efforts to elucidate critical immune cell mechanisms governing tissue residency and detection of aberrant cell states, with the aim of detecting and preventing diseased states.
• Develop a transformative research vision and providing technical guidance and mentorship to team members.
• Engage with colleagues throughout the Biohub and Biohubs ecosystem to uphold our values of scholarly excellence, innovation, open communication, hands-on collaboration, partnership, and research opportunities.
• Clearly communicate progress and results to colleagues and to the leadership team.
• Publish and disseminate impactful findings and the products of your research as preprints (medRxiv, bioRxiv) and/or software repositories (e.g., GitHub) and embrace the OpenScience policy of the Biohub network.
• Collaborate with the CZ Biohub team to patent and license technologies resulting from your research.

What You'll Bring

• PhD or MD with relevant research experience.
• An exceptional publication record demonstrating both the candidate’s creativity and productivity
• A minimum of 3 years post-doctoral experience or clinical training
• Demonstrated leadership, track record of innovation, and ability to work collaboratively.
• Supervisory or mentoring experience is a plus but not required for early-career applicants, but expected for more senior candidates.
• A creative vision to carry out or continue an innovative and impactful research program.
• Outstanding interpersonal and communication skills.
• Demonstrated commitment to open science and highly aligned with the mission and values of  CZ Biohub values.

Compensation

The New York City, NY base pay range for a new hire in this role is $153,000.00 - $185,000.00. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process. 

Better Together

As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.

Benefits for the Whole You 

We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible. 

• Provides a generous employer match on employee 401(k) contributions to support planning for the future.
• Annual benefit for employees that can be used most meaningfully for them and their families, such as housing, student loan repayment, childcare, commuter costs, or other life needs.
• Life of Service Gifts are awarded to employees to “live the mission” and support the causes closest to them.
• Paid time off to volunteer at an organization of your choice. 
• Funding for select family-forming benefits. 
• Relocation support for employees who need assistance moving.

If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.

#LI-Hybrid #LI-Onsite