We are looking for a Reagent Manufacturing Associate II, Oncology to join our growing reagent manufacturing team in support of clinical patient testing in our high throughput CLIA lab. The Reagent Manufacturing Associate II will be responsible for assisting with the manufacturing, assembly, and qualification of reagents in support of clinical laboratory operations at BillionToOne. The selected candidate will also be responsible for assisting in the troubleshooting of reagent manufacturing activities, management of sufficient reagent inventory, and operation of high-throughput automated equipment to support operations. . This position requires an individual with excellent attention to detail, effective written and verbal communication skills, the ability to multitask, and the ability to work both independently and as part of a highly collaborative team environment. The role is a full-time onsite position in Menlo Park, CA and reports to Senior Process Engineer II, Oncology. 

Shift Hours: Monday - Friday, 9am - 5pm

Responsibilities:

• Manufacture medium and high complexity reagents in a molecular manufacturing lab according to established SOPs.
• Operation of robotic laboratory equipment and traditional lab equipment (micropipettes, liquid handlers, thermal cyclers, centrifuges, sealers, sonicator, etc.)
• Use of traditional molecular biology processes and techniques (small volume pipetting, plating, quantitation, visual inspection)
• Maintaining thorough, accurate and detailed documentation of all work produced, including deviations
• Inventory management
• Collaborate with Research and Development for the scale-up and implementation of new reagent formulations.
• Participate in reagent troubleshooting and quality monitoring
• Lab maintenance such as labware cleaning and equipment maintenance as needed
• Daily completion of assigned tasks to keep manufacturing on track
• Reagent manufacturing will primarily be operating out of Menlo Park but may require some flexibility to work out of the Union City location

Requirements:

• Bachelor’s degree or equivalent degree in biology, chemistry, or clinical related sciences
• At least one year of experience with molecular biology techniques in a research or clinical laboratory
• Excellent attention to detail
• Effective written and verbal communication skills
• The ability to multitask and work independently
• Patience and flexibility
• Previous clinical laboratory experience is preferred

Nice-to-Haves:

• Start-up experience
• Experience in a cell-free DNA setting
• Experience developing training programs and performing knowledge transfer.
• Strong communication skills (verbal and written).
• Ability to effectively work in a team environment and build strong working relationships.
• High degree of initiative and self-motivation.

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Free UNITY Complete NIPT testing for employees & spouses
• Supplemental fertility benefits coverage
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Free daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $105,218 per year, including a base pay range of $80,388 - $91,107 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

BillionToOne is seeking a Clinical Laboratory General Supervisor (GS) to support our Oncology product, Northstar, in a high-complexity CLIA laboratory environment. This role provides general supervision of personnel and daily laboratory operations, ensuring regulatory compliance, quality, and operational excellence across end-to-end cancer blood sample processing.

This is a hands-on leadership role in a fast-growing, high-throughput molecular diagnostics lab. The General Supervisor will serve as a key operational leader and first point of escalation for CLS and CLA, partnering closely with the Technical Supervisor, Laboratory Director, and Quality team.

This is an onsite position supporting the Monday–Friday Mid Shift (11:30 AM – 8:00 PM), with a planned transition to a PM shift (3:00 PM – 11:30 PM) later this year.

Responsibilities:

• General Supervision & Leadership
  • Serve as a designated CLIA General Supervisor for high-complexity testing in accordance with 42 CFR Part 493 and CAP accreditation standards
  • Provide day-to-day supervision of laboratory personnel, including CLSs and CLAs, during the pre-analytic, analytic, and post-analytic phases of testing
  • Act as the primary escalation point for technical, operational, and personnel issues during assigned shifts
  • Oversee staffing, scheduling, shift handoffs, and workload distribution to ensure operational continuity
• Laboratory Operations & Testing
  • Perform and oversee high-complexity molecular oncology assays, supporting diagnostic testing for patient care
  • Ensure proper instrument operation, calibration, maintenance, and troubleshooting
  • Review, interpret, and verify test results and quality control data
  • Identify, investigate, and resolve deviations that may impact test performance or result integrity
• Quality & Compliance
  • Ensure compliance with CLIA, CAP, state, and local regulatory requirements
  • Perform, review, and document quality control, corrective actions, and preventive maintenance
  • Participate in inspection readiness, audits, and regulatory responses
  • Lead or support SOP development, review, and biennial updates
• Training & Continuous Improvement
  • Lead training, onboarding, and competency assessments for new and existing laboratory staff
  • Provide hands-on and theoretical training for new assays, processes, and instrumentation
  • Support process improvement initiatives, including assay validation, tech transfer, and troubleshooting
  • Partner cross-functionally with Quality, R&D, and Operations to drive continuous improvement

Qualifications:

• Active California Clinical Laboratory Scientist (CLS) license (or CGMBS/generalist license) meeting CLIA requirements for high-complexity testing
• Bachelor’s degree in chemical, biological, physical, clinical laboratory science, or a related field
• Minimum 4 years of clinical laboratory experience, including molecular and/or high-complexity testing
• Meets CLIA General Supervisor qualifications under 42 CFR 493.1461, including appropriate education, training, and experience
• Demonstrated hands-on experience with molecular biology techniques (e.g., DNA extraction, PCR, automated liquid handlers)
• Strong working knowledge of LIMS, quality systems, and laboratory documentation
• Proficiency with Google Docs, Excel, Word, and basic statistical analysis
• Excellent attention to detail, organizational skills, and ability to perform under time-sensitive conditions
• Strong written and verbal communication skills and a collaborative leadership style

Nice-To-Haves:

• Prior experience serving as a CLIA General Supervisor
• Startup or high-growth laboratory experience
• Background in medical genetics or oncology diagnostics
• Experience working with cell-free DNA (cfDNA) or next-generation sequencing workflows

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage 
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of $217,805 per year, including a base pay range of $158,401 - $179,521 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

We are looking for a detail oriented Accessioner (Part-Time) to be responsible for assisting with the day-to-day laboratory preparation and equipment maintenance in the Clinical Laboratory. The Accessioner will also be responsible for the accessioning of clinical specimens, performing quality assurance procedures, and complying with all local, state, and federal laboratory requirements. The nature of the work performed by an Accessioner requires excellent attention to detail, effective written and verbal communication skills, the ability to multitask, and the ability to work both independently and in a team environment.

This is a part time position (24 hours/week maximum) with Saturday 8am-4:30pm required. 

Responsibilities:

• Perform sample accessioning procedures according to the laboratory’s standard operating procedures
• Prepare documents for equipment and personnel records
• Perform and document routine maintenance of equipment
• Prepare other clinical documentation as required and assigned
• Clean labware, equipment, and benches
• Prepare reagents required for testing
• Write and review controlled documents as assigned

Qualifications:

• Bachelor’s degree or equivalent in biology-adjacent field, or student currently pursuing biology degree
• Able to integrate and apply feedback in a professional manner
• Strong attention to detail
• Able to manage daily specimen processing needs with high emphasis on quality
• Able to analyze and problem solve basic issues that impact test performance
• Able to proactively communicate consistently, clearly, and honestly

Nice-To-Haves:

• Clinical Laboratory experience or equivalent high complexity and volume laboratory experience
• Laboratory experience within the last year preferred

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Daily on-site lunches provided from top eateries
• Latest and greatest hardware (laptop, lab equipment, facilities)
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of (1) competitive base pay and (2) the opportunity for professional growth.

For this position, the base pay rate is $21.12 per hour.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

We are looking for a driven Clinical Laboratory Scientist (with California Clinical Laboratory Scientist License) to perform Northstar. You will join our growing superstar CLIA team responsible for end-to-end processing of cancer blood samples in a high complexity, high-growth CLIA setting. The Clinical Laboratory Scientist is an onsite position.

Shift Hours: Tues - Sat PM (1:30-10 PM)

• Weekday PM, 20%
• Weekend PM, 25%

Responsibilities:

• Performs clinical laboratory assays to provide data for diagnosis, treatment, and prevention of disease
• Performs quality control studies to ensure the accuracy of clinical data
• Verifies instrument performance by checking and calibrating specific lab instruments and documents data
• Organizes and contributes to R&D to CLIA tech transfer and troubleshooting, training, and validations

Qualifications:

• Bachelor's degree in the chemical, physical or biological sciences
• 1-2 years of CLS experience in a clinical setting
• A current California Clinical Laboratory Scientist License that meets requirements for Testing Personnel under CLIA regulations (42 CFR, part 493) (ASCP, CGMBS or generalist license is required)
• Hands-on training and experience with manual molecular biology protocols, including DNA extraction and PCR
• Advanced knowledge of Google Docs, Word, Excel, basic statistics and familiarity with LIMS systems
• Strong attention to detail and ability to work flexibly and well under given timeframes
• Self-starter and dynamic team player with excellent verbal and written skills

Nice-To-Haves:

• Start-up experience
• Knowledge of cancer biology
• Experience in a cell-free DNA setting

Benefits And Perks:

• Working alongside brilliant, kind, passionate and dedicated colleagues, in an empowering environment, toward a global vision, striving for a future in which transformative molecular diagnostics can help millions of patients
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered up to 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Supplemental fertility benefits coverage 
• Retirement savings program including a 4% Company match
• Increase paid time off with increased tenure
• Latest and greatest hardware (laptop, lab equipment, facilities)
• Daily on-site lunches provided from top eateries
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

"}" data-sheets-userformat="{"2":769,"3":{"1":0},"11":4,"12":0}">At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based on experience and salary/equity options split that the candidate chooses), (2) generous equity options offering, (3) corporate bonus program, on top of (4) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave, etc.).

For this position, we offer a total compensation package of up to $156,194 per year, including an hourly rate of $59.14 - $67.29 per hour. Compensation is commensurate with experience and leveling.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.