What You Will Contribute To Altos

An exciting opportunity is available for a Scientist II to join the Larrieu group at Altos Labs, Cambridge Institute of Science (Cambridge, UK). At Altos, the Larrieu lab is exploring both fundamental questions and translational opportunities. We are seeking a very highly motivated, versatile, creative, and collaborative individual, who is passionate and dedicated about employing their expertise to unravel the deep biology of cell health and resilience. This includes the elucidation of the mechanism of action of specific interventions that can reverse, halt or mitigate the effects of ageing on cell health. 

Responsibilities

• Elucidate processes that contribute to the age-related erosion of cell/tissue resilience.
• Engage in ground-breaking and innovative science and in Altos scientific activities.
• Develop project-specific experimental strategies, techniques, and procedures including new assays and pipelines to support translational projects.
• Lead, design and execute in vitro and in vivo experiments for identification and validation of targets with therapeutic potential
• Develop and implement biochemical and cellular assays to support screening and characterization of potential candidate therapies
• Collaborate widely across Altos to multiply efforts, gain insight into the centrality of the nuclear envelope in ageing and identify potential new therapeutic avenues          
• Collaborate with multidisciplinary teams including chemists, pharmacologists, and bioinformaticians to advance drug discovery projects.
• Present data to a variety of audiences including senior executives through entry-level employees.

Who You Are

Minimum Qualifications

• PhD in life sciences with 3-5 years of relevant postdoc/industry experience
• Extensive experience in mammalian cell culture (including primary cells).
• Strong background in molecular and cell biology with experience in assay development and validation, to support pre-clinical studies.
• Experience in small rodent handling, with an ability to independently design and coordinate the execution of complex in vivo studies, including drug administration, tissue harvest and processing.
• Strong sense of collective ownership of projects within the group and Altos.
• Critical, visionary, and creative thinking with an ability to formulate scientific questions, design strategies, and implement plans effectively.
• Strong organizational skills to manage multiple tasks simultaneously, prioritize workloads, and meet deadlines.
• High level of rigor and precision in experimental procedures, data recording, and documentation.
• Problem-solving skills to identify potential issues, test, and develop innovative solutions.
• Excellent writing and communication skills
• Ability to maintain cooperative working relationships with a broad range of people, including staff colleagues, lab members and the community

Preferred Qualifications 

• Understanding of in vivo delivery systems such as AAV, LNP, lentivirus etc.
• Biochemistry skills, including biochemical and enzymatic assay development
• Some proficiency in R and Python to support data analysis
• Prior industry experience

The salary range for Cambridge, UK:

• Scientist II, Biological Sciences: £61,400 - £80,800

Exact compensation may vary based on skills, experience, and location.

#LI-NN1

For UK applicants, before submitting your application:

- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice)
- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

What You Will Contribute To Altos

In this role you will support a dynamic research discovery team focused on science related to cellular rejuvenation and aging in human health. Primary job responsibilities involve utilization of advanced cellular assays using human induced pluripotent stem cell (iPSC) models. You will use your knowledge of research laboratory operations and scientific communication to drive experimental outcomes to support emerging therapeutic hypotheses.

Responsibilities:

• Execute and conduct research and development experimentation within a tissue culture laboratory setting where you support multiple research projects and coordinate with multiple project teams.
• Proactively evaluate research activities to determine where new information, methods, or collaborations could positively impact projects and improve efficiency of processes.
• Develop and implement innovative laboratory techniques and systems needed to meet the lab’s research goals, and provides technical training and mentorship on these methodologies. 
• Offers strong sound theoretical knowledge with the ability to independently troubleshoot processes and challenges using first-hand experience.
• Interprets experimental results, innovates new approaches, and prepares findings for supporting Altos research projects including opportunities to publish and present in peer reviewed journals and conferences.
• Function as the subject matter expert, training facilitator, and scheduling coordinator for highly specialized in vitro culture assay workflows.

Who You Are:

• Bachelor’s or Master’s degree plus at least five years of hands-on experimental laboratory experience performing mammalian tissue culture techniques (industry or academia).
• Demonstrated proficiency in the following methodologies, with a commitment to continuous advancement and optimization:
• Mammalian cell culture techniques (aseptic technique, viability, passaging, transfections)
• High throughput 96 and 384 well plate set-up for downstream analysis
• IF sample preparation, flow cytometry preparation
• RT-qPCR, RNA/DNA isolation, immunoblot
• iPSC experience 
• Fluency with spreadsheets and statistical data analysis
• Excellent electronic lab notebook (ELN) record keeping skills and/or familiarity operating within the standards of a GMP/GLP environment.
• Proven ability to set functional independent goals based on experimental needs and succinctly and accurately communicate scientific results within a multidisciplinary project team.
• Effective team communication via written documents, slide decks, and meeting participation. 

The salary range for Redwood City

• Senior Research Associate: $109,200 - $140,000

Exact compensation may vary based on skills, experience, and location.

#LI-NN1

For UK applicants, before submitting your application:

- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (bit.ly/eu_uk_privacy_notice)
- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

Senior Administrative Project Coordinator  / Administrative Project Coordinator 

What You Will Contribute to Altos

An exciting opportunity is available for an experienced Administrative Project Coordinator to join Altos Labs. The position requires advanced organisational, administrative, and analytical skills/support. Duties and tasks are complex in nature where considerable judgment, independent action and a high degree of initiative are required in resolving problems and making recommendations. Work is performed under limited supervision as part of a small team that provides operational support across the Cambridge Institute. 

The responsibilities of the role are split across administrative support for leaders and their teams; Project management and operational support and coordination for Cambridge-based Discovery Science/ IoC/ IoT/ Corporate Function teams; and operational support and project management for initiatives at the Cambridge Institute. The position requires the ability to work with insight, tact, confidentiality, and diplomacy to deal effectively with individuals at all levels.

As part of a small team, the role holder will need to work seamlessly with colleagues across Altos (often globally) and with the Cambridge Admin Team to ensure there is effective support and coverage for the smooth running of the Cambridge site.

Responsibilities

Vice President Administrative Support (25%)

• Provide administrative support for a number of senior leaders (VP/ PI) and limited support for their laboratory teams
• Manage calendar and coordinate scheduling, including lab meetings, internal and external meetings, team offsites/ retreats, conferences, professional engagements, and travel.
• Coordinate domestic and international travel arrangements and prepare travel itineraries.
• Assist with the logistics of the recruitment and onboarding process in partnership with hiring managers and Talent Acquisition Team.
• Process and track reimbursements from multiple sources.

Functional Operational Support, Coordination and Project Management (35%)

Working in close collaboration with the local team to provide support for Cambridge-based functional colleagues (e.g. IoC, IoT, EHS). Example responsibilities may include: 

Local IoC Team

• Administrative and operational support and planning for the Cambridge-based IoC team including coordination of team meetings (Wednesday group meetings, BioML meetings, IoC all-hands follow up in CI), supporting coordination of cross-site meetings (cTRC, cPRC, CSVL), Hackathon planning, team offsites/ retreats, conferences, travel and expenses.
• Provide limited administrative support for the Senior Director, AI/ML Genomics such as complex meeting arrangements.
• Assist with the logistics of the recruitment and onboarding process for new local IoC team members, in partnership with hiring managers and Talent Acquisition Team ON/ offboarding, interview scheduling, placement student recruitment.
• Support local IoC team on tracking and co-ordination of budgets, travel and expenses questions and coordination
• Organise IoC team events at CI (new starters, birthdays, leavers, etc)
• Act as conduit for general Altos and general CI admin comms into IoC teams (e.g. chasing to sign policies, coordinating local events, facilitating Reflections, etc)
• Directing IoC team members to the right people and sources of information company wide
• Act as primary point of contact for IoC visitors to CI and facilitate onsite setup and preparation for CI Leadership Team retreats

Local IoT Team:

• Administrative and operational support and planning for the Cambridge-based IoT team including coordination of team meetings, internal and external meetings, team offsites/ retreats/ events, conferences, travel and expenses.
• Provide limited administrative support for the Chief of Science Operations such as complex meeting arrangements.
• Assist with the logistics of the recruitment and onboarding process for new local IoT team members, in partnership with hiring managers and Talent Acquisition Team. 
• Support local IoT team on tracking and co-ordination of budgets
• Projects - project/process management support for IoT projects including scheduling and tracking actions.

Corporate Functions:

• EHS - Working closely with the Director, Environment, Health & Safety to support CI EHS deliverables and projects/ programmes. Provision of secretariat support for CI Health & Safety Committee.
• Project/process management support for local delivery of corporate projects such as launches, events and communications.
• Events - support for local and Altos-wide corporate events, including seminars, cross-institute meetings and events 
• Communications - assist with local deployment of global / local communications. 

Cambridge Site Operational Support and Project Management (40%)

Collaborating with colleagues locally and across Altos to ensure smooth running of the facility, events and activities, which may include:

• A broad range of office management deliverables including local communications - slack, email, posters, newsletter etc, office supplies, purchase orders for vendors, advising/ helping colleagues with operational processes such as travel booking or expenses claims.

• Support for site committees/ meetings as required, including drafting agendas, taking effective minutes, documenting and tracking actions.
• Events - responsible for supporting organisation and delivery of Cambridge quarterly social events (including the holiday party), cultural events, fortnightly CI Connect and other ad hoc events during the year.
• Provide local operational support for Altos-Wide/ Functional All Hands and Town Hall meetings ensuring they run smoothly including diarising, room bookings, co-ordination of Facilities and IT requirements and support, rehearsal/ testing co-ordination, timely local reminders and supporting those speaking at the site.
• Coordination of internal and external visitors to the site, including sensitive visitor process, organising logistics and arranging transport and accommodation required. Advising on timing of visits and travel requirements, supporting visitor itinerary planning and meetings/ seminars planned.

• Collaborate with administration colleagues across Altos and Cambridge Administration Team on effective processes and procedures, process improvements, operational initiatives, site-wide events and institute activities.
• Work closely with the Social Committee to generate ideas and collect feedback on Cambridge events.
• Maintain a roster of external suppliers for events, onboard new vendors as required, manage bookings and briefing vendors on requirements.
• Plan events and track spend against budget.

Who You Are

Minimum Qualifications

• 5+ years of relevant experience working in similar role(s)
• Exceptional organisational and time management skills with the ability to prioritise a diverse range of tasks and multiple stakeholders
• Excellent verbal and written communications skills. Able to interact professionally across the organisation and with external stakeholders and vendors.
• Strong computer skills, including advanced knowledge of Google Workspace and Microsoft Office Suite (Word, Excel, Outlook) and a willingness to learn new software/ adopt AI tools.
• Experience of project management and delivery, able to drive longer-term project deliverables alongside day-to-day work.
• Ability to pick up new processes and technology quickly and create/ build processes to optimise efficiency and continuous improvements.
• Strong organisation and multitasking skills with a sense of urgency.
• High level of discretion and confidentiality when handling sensitive information.
• Approaches new challenges and high-pressure situations with a positive attitude and calm demeanor
• Proactive and resourceful with strong attention to detail.
• A positive, can-do attitude with the ability to work independently and as part of a team

Senior Admin Project Administrator

Hiring Range: £47,100- £62,000

Admin Project Administrator

Hiring Range: £42,600- £56,000

Level will depend on experience