What You Will Contribute To Altos 

The Mass Spectrometry Hub sits within the Institute of Technology, where we have access to an array of cutting edge instrumentation. Together we are a team with a wide variety of skills and experiences that tackle exciting challenges across all of Altos. The Scientist /  Senior Scientist, Metabolomics Group Lead is responsible for end-to-end management of metabolomics and lipidomics projects, from experimental design through sample preparation, measurement, data processing and data delivery. This role partners cross-functionally with scientific and bioinformatics teams to ensure robust, reproducible data generation, maintain operational excellence of LC-MS platforms, and drive projects to successful and timely completion.

Responsibilities

• Collaborate with cross-functional scientists to define project objectives, assess feasibility, and establish clear deliverables and timelines
  
  
• Execute and supervise sample preparation workflows for steady-state metabolomics and lipidomics
  
  
• Operate, maintain, and troubleshoot LC-MS instrumentation (e.g., Thermo Exploris 240, SCIEX 7500, Vanquish HPLC) to ensure optimal performance and minimal downtime
  
  
• Optimize and adapt extraction protocols to support analysis of diverse and challenging biological samples
  
  
• Process and analyze raw datasets with software (e.g. Skyline, Compound Discoverer), and coordinate with bioinformatics teams to ensure accurate data processing, quality control, and efficient project execution
  
  
• Maintain accurate and up-to-date project tracking and documentation in systems, such as Benchling, and shared project management tools
  
  
• Communicate project status, timelines, and risks effectively to internal stakeholders and leadership
  
  

Who You Are 

Minimum Qualifications

• PhD (or equivalent experience) in metabolomics, lipidomics, analytical chemistry, biochemistry, or a related discipline.
• >6 years of hands-on experience with both HRAM and LRMS preferably with Orbitrap Exploris and SCIEX triple quadrupole mass spectrometry platforms.
• Strong experimental design and problem-solving skills, with experience performing sample preparation of cells, tissues, and biofluids.
• Demonstrated experience with mentoring and project management, including managing collaborations with scientists with diverse training backgrounds

Ideal candidates would satisfy two or more of the following preferred qualifications

• Experience developing new methods for analysis of metabolites/lipids of interest
• Prior experience in Metabolite Identification and trapping in the context of drug metabolism
• Experience performing large-scale discovery studies of > 1,000 samples
• Experience designing and interpreting complex isotope tracing experiments (e.g., metabolic flux analysis)
• Experience integrating metabolomics/lipidomics with other omics, including proteomics and transcriptomics  

Salary Range: Redwood City, California

Scientist II: $156,800- $201,000

Senior Scientist : $172,400- $221,000

This is an on- site role

Equal Opportunity Employment

We value collaboration and scientific excellence.

We believe that diverse perspectives and a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.

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