Jobs Companies Rezotx Director/Senior Director, In Vivo Pharmacology

Über diese Director/Senior Director, In Vivo Pharmacology Stelle bei Rezotx

Rezotx · Vor Ort · San Francisco, CA
About Rezo Therapeutics
Rezo is a different kind of biopharma company. Our mission is to dramatically increase the success rate of drug development by building a disease-agnostic, fully-integrated, network biology platform that will redefine our understanding of human disease and ability to treat it.  
 
We are leveraging a unique integrated approach, combining capabilities in genetics, proteomics, structural biology and AI to generate deep biological insights and novel therapeutic approaches.
 
Located in San Francisco’s vibrant Mission Bay neighborhood, Rezo is in close proximity to UCSF, numerous urban amenities, and outdoor recreational opportunities. We recognize that realizing our mission depends as much on our people as it does on our science and are building a workplace that fosters collaboration, respect, and diversity where contributing to your team’s success is valued as highly as individual achievements.  If you’re passionate about team science and breaking down barriers to progress in drug development, please consider joining us! 

The Opportunity
Rezo is seeking an experienced Director/Senior Director of In Vivo Pharmacology to lead the strategy, design, execution, and interpretation of in vivo pharmacology studies across our oncology portfolio.

The successful candidate will bring deep expertise in oncology models, PK/PD-driven study design, translational pharmacology, and cross-functional drug discovery. They will work closely with biology, medicinal chemistry, DMPK, and external CRO partners to generate robust, decision-driving in vivo data packages.

This is an opportunity to build and shape the in vivo pharmacology function at a growing oncology biotech, with direct impact on program strategy and portfolio progression.

Key Responsibilities:

  • Lead the in vivo pharmacology strategy for Rezo’s small-molecule oncology programs, including study design, model selection, dose/schedule optimization, PK/PD integration, efficacy assessment, and translational interpretation.
  • Design and oversee in vivo studies in CDX, PDX, syngeneic, as appropriate for each program and mechanism.
  • Develop pharmacology plans that support development candidate nomination, IND-readiness, and early clinical translational strategy.
  • Integrate tumor efficacy, exposure, pharmacodynamic biomarkers, tolerability, and mechanism-of-action data to guide compound prioritization and program decisions.
  • Mentor and potentially manage scientists as the organization grows.
  • Qualifications:

    • PhD in pharmacology, cancer biology, molecular biology, physiology, translational medicine, or a related discipline, with typically 10+ years of relevant industry experience in oncology drug discovery or translational pharmacology.
    • Deep expertise in in vivo pharmacology for small-molecule oncology drug discovery.
    • Strong track record designing and interpreting efficacy, PK/PD, dose-response, dose-scheduling, and mechanism-of-action studies in oncology models.
    • Hands-on experience with rodent oncology models and a strong understanding of the strengths, limitations, and translational relevance of CDX, PDX, and syngeneic models.
    • Demonstrated ability to integrate in vivo pharmacology with medicinal chemistry, DMPK, and biomarker strategy.
    • Experience advancing programs from discovery through development candidate nomination.
    • Strong CRO management experience, including protocol design, study oversight, data QC, troubleshooting, and vendor accountability.
    • Ability to operate at both strategic and detailed execution levels in a small-company setting.

    Compensation at Rezo
    The expected starting salary range for this position based in San Francisco, California for Director/Senior Director is $195,000-$290,000. Actual starting salary will be determined based on multiple job-related factors including candidate’s skills, education, and experience, the level at which they are hired, market demand, business needs, and internal parity. This role is eligible for participation in our Annual Discretionary Bonus Plan (based on individual and company performance) and our Equity Incentive Plan, subject to the terms of those plans and associated policies. This position is also eligible for the benefits detailed below.

    Benefits at Rezo
    Medical (HMO or PPO), dental, and vision insurance
    Discretionary time off policy
    Company holidays (including summer and winter shutdown)
    401(k) retirement savings program
    Commuter / Mass Transit Benefit Program
    Healthcare Flexible Spending Account (FSA)
    Dependent care Flexible Spending Account (FSA)
    Parental leave
    Competitive compensation
    Flexible work schedule
     
    EEOC
    At Rezo we value a diverse, equitable, inclusive workplace and provide equal employment opportunity to all persons without regard to race, color, sex, gender identity, gender expression, religion, age, national origin, ancestry, citizenship, physical or mental disability, medical condition, family care status, marital status, domestic partner status, sexual orientation, genetic information, military or veteran status, or any other basis protected by federal, state or local laws.  This statement covers all facets of employment and is especially important when it comes to growing our team.  
     
    If you are wondering if you’ll belong at Rezo, or are worried that you don’t meet 100% of the qualifications for this role, take a chance on us and yourself — please apply!
     
    SF Fair Chance Ordinance
    Pursuant to the San Francisco Fair Chance Ordinance, Rezo considers qualified applicants with arrest and conviction records for employment.
    Bereit, sich bei Rezotx zu bewerben?
    Bei Rezotx bewerben

    Ähnliche Jobs

    Rezotx
    Associate Director/Director, Medicinal Chemistry
    Rezotx
    ⚡ Früh bewerben San Francisco, CA Vor Ort $160,000–$240,000
    ● Neu 👁 Gesehen ✓ Beworben vor 1 Mon.
    Rezotx
    Staff/Senior Staff, Bioinformatics Data Scientist
    Rezotx
    ⚡ Früh bewerben San Francisco, CA Vor Ort $180,000–$260,000
    ● Neu 👁 Gesehen ✓ Beworben vor 1 Mon.
    Socure
    Head of FCRA Operations and Compliance
    Socure
    ⚡ Früh bewerben Hybrid - US Hybrid $220,000–$275,000
    ● Neu 👁 Gesehen ✓ Beworben vor 5 Std.
    Socure
    Senior Product Manager - Document Verification
    Socure
    ⚡ Früh bewerben Hybrid - US Hybrid $170,000–$205,000
    ● Neu 👁 Gesehen ✓ Beworben vor 5 Std.
    Socure
    Senior Product Manager, Core Fraud Services
    Socure
    ⚡ Früh bewerben Hybrid - Seattle, WA Hybrid $170,000–$220,000
    ● Neu 👁 Gesehen ✓ Beworben vor 5 Std.
    Redwood Materials
    Infrastructure Software Engineer, Energy Storage
    Redwood Materials
    ⚡ Früh bewerben San Francisco, California, Uni... Vor Ort $180,000–$237,500
    ● Neu 👁 Gesehen ✓ Beworben vor 6 Std.
    Stitch Fix
    Lead Engineer - Product Catalog Team
    Stitch Fix
    ⚡ Früh bewerben Remote, USA · standortgebunden $111,800–$186,000
    ● Neu 👁 Gesehen ✓ Beworben vor 6 Std.
    Stitch Fix
    ML Platform Engineer
    Stitch Fix
    ⚡ Früh bewerben Remote, USA · standortgebunden $136,000–$167,000
    ● Neu 👁 Gesehen ✓ Beworben vor 6 Std.
    Redwood Materials
    Business Operations Associate
    Redwood Materials
    ⚡ Früh bewerben San Francisco, California, Uni... Vor Ort
    ● Neu 👁 Gesehen ✓ Beworben vor 7 Std.

    Registrieren für Vorschläge, die auf die von Ihnen geöffneten Jobs und gespeicherten Suchen zugeschnitten sind.

    Mehr Jobs bei Rezotx

    Alle Jobs bei Rezotx ansehen →

    Jetzt bewerben
    🤖

    Moment — langsam

    JobsRadar wurde für echte Menschen gebaut, die eine schwere Zeit bei der Jobsuche haben — nicht für automatisierte Anfragen. Sie klicken viel zu schnell und sind jetzt vorübergehend blockiert.

    Kommen Sie später wieder. Wenn Sie wirklich auf Jobsuche sind, stehen wir hinter Ihnen — verhalten Sie sich einfach wie ein Mensch.

    Catch your next role the second it’s posted.

    Create a free account and we’ll watch the boards for you — the instant a job matches your search, it lands in your inbox or Telegram. No digging, no refreshing.

    Create free account

    Free forever · takes 30 seconds · already have one?

    Verschaffe dir einen Vorsprung bei der Jobsuche.

    Tritt unserem Telegram-Kanal bei für das, was dir hilft, die Stelle zu bekommen — Gehaltsbenchmarks, den wöchentlichen Marktpuls und neue Feature-Drops. Kein Spam, nur Signal.

    Dem Kanal beitreten — kostenlos