Summary:

The Director, Business Operations (Global QC) will lead the strategic design, implementation, and continuous optimization of global operational frameworks supporting Vaxcyte’s Quality Control (QC) and supporting Analytical interfaces. This role ensures that analytical inputs and QC operations are scalable, compliant, efficient, and aligned with corporate and regulatory expectations as the organization advances from development through commercial readiness.

The Director will serve as the central business operations leader for the Global Quality Control, partnering with leaders in Analytical Development, Analytical Science & Technology, Stability, Process Development, Manufacturing Science and Technology (MS&T), and Quality. This individual will drive governance, process standardization, infrastructure development, and cross-functional coordination to enable timely, compliant, and uninterrupted supply of Vaxcyte’s innovative vaccines.

Essential Functions:

Operational Excellence & Strategy
•    Lead the design and execution of operational strategies that translate Vaxcyte’s global vision into efficient, compliant, and scalable QC and analytical business operations.
•    Develop and maintain a global QC operations strategy, ensuring alignment with clinical and commercial objectives.
•    Implement continuous improvement frameworks (e.g., Plan-Do-Check-Act) to enhance efficiency, scalability, and compliance across analytical and QC processes.
•    Define and monitor key performance indicators (KPIs) that assess operational performance, quality, delivery timelines, and cost efficiency across the global analytics network.
•    Partner with cross-functional leaders to ensure analytical and QC infrastructure, systems, and processes are integrated into overall business objectives.
•    Lead initiatives that improve operational automation, data visibility, and process robustness.

Governance & Compliance
•    Establish and maintain robust governance frameworks for QC and analytical operations in alignment with global cGMP regulations and internal quality standards.
•    Define, visualize, and formalize QC business processes using RASCI principles, ensuring clear ownership and accountability across the analytical network.
•    Review and enhance the Quality Management System (QMS) infrastructure to close gaps, harmonize SOPs, and strengthen procedural consistency.
•    Ensure data integrity principles are embedded in all operational practices, compliant with Vaxcyte’s DI policies and global standards.
•    Support global inspection readiness and lead preparations for regulatory inspections, partner audits, and customer reviews.
•    Collaborate with Quality to ensure analytical operations and contract testing laboratories meet all compliance requirements.

Infrastructure & Systems Leadership
•    Oversee the development and validation of business systems, data management platforms, and documentation practices across global analytical and QC sites.
•    Ensure that contract and in-house laboratories maintain robust equipment qualification, calibration, and maintenance programs to support reliable analytical testing.
•    Lead network and site planning activities, including external partnerships and outsourcing strategies with CDMOs and CROs.
•    Develop business cases for laboratory expansion, outsourcing scenarios, and infrastructure investments to support strategic growth.

Capability Building & Team Leadership
•    Collaborate and mentor a global team of QC operations professionals to ensure scientific, technical, and operational excellence.
•    Drive training programs that enhance technical proficiency, compliance culture, and cross-functional understanding within the analytics organization.
•    Foster a culture of innovation, learning, and continuous improvement across the analytical network.
•    Collaborate closely with functional heads across Analytical Development, Analytical Science and Technology, Stability, and Manufacturing to harmonize operational practices.
•    Represent Global Analytics and QC Operations in governance bodies, steering committees, and cross-functional business forums.

Requirements: 

•    Bachelor’s or Master’s degree (or higher) in Biotechnology, Pharmaceutical Sciences, Engineering, or related field.
•    12+ years of progressive experience in Quality Control, Analytical Operations, or Technical Operations within a biotechnology or pharmaceutical company.
•    Demonstrated leadership in developing and managing operational systems in GMP-regulated environments.
•    Strong understanding of cGMP, global regulatory requirements, and analytical testing operations.
•    Proven ability to design and implement business processes, governance models, and performance management systems.
•    Experience with vendor management and collaboration with CDMOs/CROs on analytical testing and QC operations.
•    Exceptional communication, negotiation, and relationship-building skills with internal and external stakeholders.
•    Strong analytical, organizational, and problem-solving skills; adept at data-driven decision-making.
•    Demonstrated passion for process improvement, operational efficiency, and automation

Summary:

We are seeking an experienced and dynamic leader to join Vaxcyte as Vice President, Manufacturing Operations & Managing Director for Vaxcyte Switzerland GmbH. This role will lead a high-performing operations organization in Switzerland, supporting late-stage development, commercial readiness, and long-term growth. The role will oversee critical capital projects, scale clinical and commercial supply capabilities, and provide strategic and operational leadership across a network of Contract Manufacturing Organizations (CMOs) in Europe to ensure reliable, compliant product supply. This position is accountable for both strategic and operational leadership of GMP activities. Strategically, the role will evolve the manufacturing network, strengthen key external partnerships, and ensure alignment with corporate objectives. Operationally, it will drive site performance, scale capabilities, and deliver program milestones. The role oversees Engineering & Facilities, Manufacturing, Sourcing, and Supply Chain, with dotted-line leadership for MSAT and Quality Control in Visp.

Partnering closely with Process Development, Quality Assurance, and Regulatory, this role will drive facility performance and network execution while developing a deep understanding of program drivers and translating these into actionable plans across internal teams and CMOs. This role is critical to ensure timely, compliant, and uninterrupted supply of Vaxcyte’s therapies. Strong GxP knowledge and deep expertise in biologics manufacturing, engineering, and organizational leadership are required.

Essential Functions:

• Provide leadership, strategic direction, and risk-based oversight to translate corporate strategy into global manufacturing execution.
• Take strong ownership of site success. Lead and manage the Vaxcyte Switzerland organization, including direct and matrixed reporting structures.
• Build and develop high-performing teams across Engineering & Facilities, Manufacturing, Sourcing, Supply Chain, MSAT, and Quality Control.
• Oversee and strategically manage CMO relationships, including participation in Joint Steering Committees (JSCs), ensuring alignment on quality, timelines, and cost.
• Oversee all CMO activities and commercial supply operations to ensure reliable, compliant delivery aligned with market needs.
• Lead capital projects, including design, construction, startup, validation, and licensing of manufacturing facilities.
• Drive facility performance, site master planning, continuous improvement, COGs reduction initiatives to support scalability and long-term growth.
• Establish and enhance manufacturing engineering and facilities capabilities supporting clinical and commercial supply.
• Develop and monitor KPIs and dashboards to track performance, risks, and progress across operations. Provide comprehensive performance reporting on the supply network to all relevant stakeholders.
• Collaborate closely with Process Development, Quality Assurance, Regulatory, and other cross-functional teams to ensure alignment and execution excellence.
• Coordinate resource planning internally and across CMOs, proactively addressing gaps, constraints, and risks.
• Serve as escalation point for critical production or supply issues, leading cross-functional response.
• Develop deep understanding of program priorities and translate into execution plans across internal teams and CMOs.
• Represent Vaxcyte in external engagements, including governmental and regional stakeholders.
• Champion operational excellence, continuous improvement, and strong GxP complian

Requirements:

MS in Science or Engineering with 20+ years of experience, or PhD with 15+ years of experience.  15+ years of leadership experience in GMP manufacturing, operations, engineering, or large-scale biologics environments. Other combinations of education and/or experience may be considered.

• Proven experience leading global manufacturing networks, including CMO oversight.
• Demonstrated success in facility startup, scale-up, and commercialization.
• Strong experience in microbial GMP manufacturing; multi-valent complex vaccines experience highly desired.
• Proven ability to build and lead high-performing, cross-functional teams.
• Experience establishing strong quality, safety, and continuous improvement cultures.
• Strong financial acumen, including capital project and budget management.
• Experience identifying and executing strategic investments.
• Ability to operate at both strategic and operational levels with strong decision-making skills.
• Excellent leadership, communication, collaboration, and stakeholder management capabilities.
• Ability to manage multiple priorities in a fast-paced environment.

Reports to: Chief Technical Operations Officer

Location: Visp, Switzerland

Compensation: The compensation package will be competitive and includes comprehensive benefits and an equity component.

Summary:

The Manager, Supply Chain Management is responsible for day‑to‑day operational execution of supply chain activities supporting Vaxcyte’s clinical, GMP, PPQ, and commercial readiness programs. This role focuses on tactical planning, execution, tracking, and issue resolution across materials, logistics, and external partners, ensuring smooth and compliant operations in support of manufacturing campaigns.

The role works closely with the Associate Director, Supply Chain, who retains end‑to‑end strategic ownership across programs, while the Manager, Supply Chain Management ensures disciplined execution, follow‑through, and operational stability.

Essential Functions:

Operational Supply Chain Execution

• Execute approved supply chain strategies and plans across GMP, PPQ, and clinical/commercial readiness activities.
• Manage day‑to‑day material planning, ordering, and tracking to ensure on‑time availability aligned with manufacturing schedules.
• Support execution of supply activities across multiple programs, with a focus on operational readiness and delivery.
• Manage and coordinate Critical Raw Materials and Customer‑Supplied Materials provided to Lonza.

Materials, Logistics & Vendor Coordination

• Coordinate shipments and storage with the Logistics Team.
• Track material movements, inventories, and material status, proactively escalating risks or delays, particularly for Critical Raw Materials.
• Act as the primary operational interface between Supply Chain and Procurement / Buyer, ensuring alignment between ordered materials, delivery timelines, and campaign execution needs.

CDMO & External Partner Support

• Support operational interfaces with CDMOs, primarily Lonza.
• Participate in recurring Lonza‑related forums (e.g. VIBEX, MINT material ordering, allocation, and operational alignment meetings).
• Follow up on action items, timelines, and required documentation to enable smooth execution.
• Support deviation‑related activities by coordinating information flow between Supply Chain, Quality, and Operations.

Tracking, Reporting & Documentation

• Maintain operational trackers, dashboards, and status updates related to materials, shipments, and readiness.
• Own the accuracy and maintenance of campaign progression data, including OMP‑related tracking, ensuring consistency across Supply Chain, Manufacturing, and Lonza‑reported data.
• Support preparation of weekly and recurring campaign updates by providing validated execution‑level data.

Issue Resolution & Continuous Improvement

• Act as a first line of response for operational issues related to materials, logistics, and execution.
• Escalate issues with clear data, options, and recommendations to the Associate Director.
• Identify opportunities to improve execution efficiency, tracking, and operational robustness.

Requirements: 

Bachelor’s degree in Supply Chain, Operations, Engineering, Life Sciences, or a related field with 7+ years of experience in Supply Chain Operations, Manufacturing Support, or a related role. Other combinations of education and/or experience may be considered.

• Experience working in a regulated biotech, pharmaceutical, or life sciences environment.
• Strong ability to work in a cross‑functional, matrix organization.
• Hands‑on experience with material planning, logistics coordination, and operational execution.
• Strong analytical, organizational, and follow‑through skills.
• Proficiency with ERP systems, SharePoint, and MS Office tools.
• Fluent in English.
• Fluency in German highly preferred; other European languages an advantage.