Summary:

Vaxcyte is seeking an Associate Scientist II (Contract), Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment.

Essential Functions:

• Perform and optimize multi-step syntheses of protein-polysaccharide conjugates.
• Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
• Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency.
• Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility.
• Assist with troubleshooting of synthesis, purification, and analytical procedures.
• Track inventory of critical reagents and assist with ordering as needed.
• Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members.
• Present experimental results and progress updates at group meetings.
• Contribute to laboratory protocols, reports, and other documentation supporting process development.
• Collaborate effectively with team members and contribute to cross-functional activities.

Requirements: 

• BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience.
• Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable.
• Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE.
• Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable.
• Strong attention to detail, organizational skills, and record-keeping abilities.
• Effective communication skills, both verbal and written.
• Ability to work both independently and collaboratively in a fast-paced environment.
• Enthusiasm for learning new skills and applying them to challenges outside of current expertise.
• Commitment to integrity, professionalism, and safety in all aspects of work.

Summary:

Vaxcyte is seeking Senior Associate Scientist (Contract), Conjugation Development, who will support the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on analysis of vendor-supplied materials in a capacity similar to a Quality Control Lab, as well as supporting the Conjugation Development team as needed. This is lab-based, full-time position that requires strict adhesion to protocols and documentation standards. The ideal candidate has strong organizational skills, clear communication, a high level of attention to detail, and experience working in a QC environment.

Essential Functions:

• Conduct analyses of vendor-supplied samples using colorimetric assays, gel electrophoresis, and liquid chromatography while strictly adhering to established SOPs
• Support lab operations
• Track shipping details for vendor-supplied samples.
• Review analytical assay data for adherence to SOPs and accuracy.
• Maintain organized records of review status of notebook entries and analytical data.
• Contribute to reports, certificates, and other documentation supporting process development.
• Collaborate effectively with team members and contribute to cross-functional activities.

Requirements: 

• BS degree in Chemistry, Biochemistry, or related field with minimum 5 years of industry experience, or MS degree with minimum 3 years of industry experience.
• At least 2 years of experience in an analytical development or quality control role.
• Prior experience running colorimetric assays is required.
• Prior experience with HPLC is required.
• Prior experience with SDS-PAGE is required.
• Excellent attention to detail, organizational skills, and record-keeping abilities.
• Ability to work both independently and collaboratively in a fast-paced environment.
• Commitment to integrity, professionalism, and safety in all aspects of work.

Summary:

Vaxcyte is seeking an Associate Scientist II (Contract), Conjugation Development, who will contribute to the development of a robust process for generating the company’s proprietary pneumococcal conjugate vaccine. This role will focus on the synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. The successful candidate will apply a strong foundation in analytical chemistry and laboratory techniques to optimize and troubleshoot processes, while also supporting related areas such as analytical development and stability studies. This position requires strong organizational skills, clear communication, and the ability to work in a fast-paced, cross-functional environment.

Essential Functions:

• Perform and optimize multi-step syntheses of protein-polysaccharide conjugates.
• Purify polysaccharides and conjugates using methods including dialysis, size-exclusion chromatography, and tangential flow filtration (TFF).
• Analyze polysaccharides and conjugates using methods such as colorimetric assays, HPLC assays, SEC-MALS, and SDS-PAGE, and contribute to method bridging studies and qualification to ensure robustness and consistency.
• Maintain accurate, well-organized experimental records and support data verification and analysis to enable process optimization and reproducibility.
• Assist with troubleshooting of synthesis, purification, and analytical procedures.
• Track inventory of critical reagents and assist with ordering as needed.
• Support maintenance of assigned lab instruments, perform general lab duties, and contribute to training new team members.
• Present experimental results and progress updates at group meetings.
• Contribute to laboratory protocols, reports, and other documentation supporting process development.
• Collaborate effectively with team members and contribute to cross-functional activities.

Requirements: 

• BS degree in Chemistry, Biochemistry, or related field with minimum 2 years of industry experience, or MS degree with minimum 1 years of industry experience.
• Experience with laboratory-scale protein purification methods such as dialysis, diafiltration, and size-exclusion chromatography; experience with TFF is desirable.
• Working knowledge of analytical methods including colorimetric assays, HPLC, SEC, and SDS-PAGE.
• Hands-on experience with protein conjugation reactions or chemical modification of polysaccharides is desirable.
• Strong attention to detail, organizational skills, and record-keeping abilities.
• Effective communication skills, both verbal and written.
• Ability to work both independently and collaboratively in a fast-paced environment.
• Enthusiasm for learning new skills and applying them to challenges outside of current expertise.
• Commitment to integrity, professionalism, and safety in all aspects of work.

Summary:

Vaxcyte is seeking an energetic and talented individual to join the Drug Product (DP) Process Development team within the broader Process Development organization. The primary responsibility of the incumbent will be to provide technical and engineering support across DP process development activities, spanning late-stage clinical supply, process characterization, tech transfer, and commercial readiness (PPQ) of Vaxcyte’s lead programs. The role requires close collaboration with internal cross-functional partners (Formulation, Analytical Development, MSAT, Quality) as well as external contract development and manufacturing organizations (CDMOs) supporting Vaxcyte’s fill/finish operations.

Due to the high number of Drug Substances (up to 31) within the DP and the aluminum-containing adjuvant system, this is arguably one of the most complex Drug Products in clinical and commercial development today, offering the right candidate an incredible opportunity to make a significant impact on the product, the company, and the industry. The successful candidate will be hands-on, detail-oriented, and comfortable operating in a fast-paced environment with fluid priorities. The role is predominantly lab- and office-based at Vaxcyte’s San Carlos headquarters, with opportunities to contribute to studies executed at both internal and external (CDMO) sites.

Essential Functions: 
•    Support the development, characterization, and qualification of robust Drug Product processes for late-stage clinical and commercial manufacturing.
•    Execute bench- and pilot-scale process development studies using down-scaled models, including compounding/mixing, sterile filtration (filter selection and sizing), fill/finish, hold time, and container/closure evaluations. 
•    Perform in-process sample testing and analysis of DP intermediates and finished product to support process monitoring, process characterization, and release.
•    Maintain accurate and timely data entry and documentation in Benchling (ELN) in accordance with Good Documentation Practices (GDP), ensuring accuracy, completeness, and compliance with established standards and regulatory requirements.
•    Analyze experimental and manufacturing data using statistical tools (e.g., JMP), identify trends, and summarize findings in technical reports and presentations.
•    Perform routine lab upkeep and housekeeping to ensure laboratory cleanliness standards are met and conduct regular inventory monitoring and reconciliation.
•    Work within a team environment and provide support as necessary to further the team’s initiatives.

Requirements: 
•    BS in Chemical Engineering, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
•    Experience in, or exposure to, early- and/or late-stage clinical fill/finish manufacturing under GMP regulations preferred.
•    Working knowledge of Drug Product unit operations, such as compounding/mixing, sterile filtration, aseptic fill, and container/closure systems (vials, PFS, cartridges).
•    Experience supporting technology transfer, scale-up/scale-down, process characterization, or CDMO-based manufacturing activities is preferred.
•    Familiarity with statistical analysis tools (e.g., JMP, Minitab) is preferred.
•    Experience using electronic lab notebook (ELN) systems, preferably Benchling, is a plus.
•    Strong interpersonal and communication skills, both verbal and written, with the ability to work effectively with internal cross-functional teams.
•    Ability to work independently and collaboratively in a fast-paced, cross-functional environment, managing multiple priorities simultaneously.
•    Ability to execute, document, and interpret drug product process development and characterization experiments, adhering to scientifically sound practices.
•    Strong technical writing, data analysis, and communication skills.

Reports to: Engineer I, Drug Product Process Development

Location: San Carlos, CA

Expected Contract Length: 12 months

Hourly Range: 51/hr. – 56/hr. 

Summary:

The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is looking for a Senior Associate Scientist (contract) with experience in microbial fermentation and upstream processing to join the Upstream Polysaccharide Process Development team. The candidate will be responsible for collaboration on experimental design and execution of experiments to further develop and optimize upstream processes for polysaccharide manufacturing using microorganisms. The successful candidate will have practical laboratory experience related to microbial fermentation processes and eager to utilize and learn new laboratory skills. The role will require >50% time in the lab and this person will be able to independently detail experimental procedures/results in written and presentation formats. The successful candidate may interface closely with the cross-functional team, write detailed technical reports, present experimental results internally, and may potentially interface with external CMO partners.

Essential Functions:

• Support in study design, execute, and analyze experiments for upstream polysaccharide for bacterial fermentation (BSL2) and vaccine production processes.
• Execute experiments to develop the upstream process parameters (e.g., media, feed, pH, temperature, dissolved oxygen, agitation, etc.) and to enhance product yield, quality, and consistency.
• Perform microbiology related work including plating, colony selection, Gram staining and cell enumeration on microscope.
• Perform fermentation vessel assembly and script writing for process automation and execute fermentation experiment in shake-flask and lab scale bioreactors.
• Prepare media and buffer as needed for experiments.
• Operate and maintain instrumentation for bacterial fermentation and primary recovery (centrifugation, filtration, etc.) of bacterial polysaccharides utilizing aseptic techniques.
• Support analytical method execution including optical density, residual metabolites and polysaccharide concentration and other relevant analytical techniques.
• Assist in executing process development studies.
• Keep accurate and current records of research and/or project related activities in laboratory notebooks and Electronic Lab Notebook.
• Prepare and review protocol, technical reports, SOPs, and batch records.
• Present and communicate scientific data and results to internal stakeholders.
• Be an outstanding teammate and collaborate effectively with cross functional team members.
• and collaborate effectively with downstream, analytical, and manufacturing teams within Polysaccharide Development and Manufacturing team to ensure seamless technology transfer and process integration.

Requirements: 

• MSc in Chemical/Biochemical Engineering, Biotechnology, or similar degree with a minimum of 3 years of relevant industry experience, or BSc with a minimum of 5 years of relevant industry experience.
• Experience in handling microorganisms with proper aseptic techniques to perform upstream processing related work in flasks/bioreactors.
• Hands-on experience and theoretical understanding of key processing operations such as microbial culture, fermentation process, microbial media, and process optimization and relevant analytical technologies; experience with depth filtration, continuous centrifugation is a plus.
• Develop and optimize scripts for instrumentation, including Ambr® systems, to enhance efficiency and automate processes, leveraging programming languages such as Python or R is a plus.
• Experience with Design of Experiments (DoE) principles and DoE software.
• Process characterization experience is a plus.
• Cell banking expertise, colony selection and genetic analysis of recombinant strains is a plus.
• Proficiency with computer programs such as Microsoft Excel, Word, PowerPoint, Visio and JMP.
• Working knowledge of GMP requirements.
• Proven ability to succeed in a cross-functional team environment, effectively managing multiple projects and contributing to team outcomes.
• Strong interpersonal skills, with excellent written and verbal communication abilities.

Summary:

The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation), and Drug Product. These Process Development teams are supported by Analytical Development and Formulation Development teams. Vaxcyte is seeking an Associate Engineer II with experience or strong foundational knowledge in vaccine or biologics process development and manufacturing to join the Polysaccharide Clinical Manufacturing/Process Development team.

The candidate will provide technical support for manufacturing activities in collaboration with CDMO partners, while also contributing to process development and process validation efforts. The position requires laboratory presence (>50%) and the ability to independently execute and document experiments, analyze data, and communicate results through technical reports and presentations. The successful candidate will collaborate cross-functionally and may interface with external CDMO partners to support manufacturing campaigns and process transfers.

Essential Functions:

• Provide remote manufacturing (MFG) oversight to support batch execution, ensuring adherence to process parameters and GMP requirements
• Participate in deviation investigations, root cause analysis, and implementation of corrective and preventive actions (CAPAs)
• Provide technical support for MFG and process development through data analysis, MFG document reviews, and supporting lab scale studies
• Perform in-process sample testing to support monitoring of MFG process performance and understanding
• Manage sample inventory, including tracking, storage, and organization of manufacturing samples
• Maintain accurate and timely documentation in electronic lab notebook (ELN) systems
• Analyze manufacturing and experimental data using statistical tools (e.g., JMP) and summarize findings in technical reports
• Collaborate with cross-functional teams including Process Development, Manufacturing, Analytical Development, and Quality
• Prepare and present technical data to internal stakeholders and support interactions with CDMO partners

Requirements: 

• BS in Chemical Engineering, Biochemistry, or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
• Experience or exposure to GMP manufacturing environments and process development activities
• Hands-on experience with in-process analytical techniques, including colorimetric and enzymatic assays
• Familiarity with upstream and downstream processing technologies, such as fermentation, UF/DF, depth filtration, and chromatography
• Experience supporting technology transfer, scale-up, or CDMO-based manufacturing is preferred
• Understanding of deviation investigations and root cause analysis methodologies
• Familiarity with statistical analysis tools (e.g., JMP) is preferred
• Experience using electronic lab notebook (ELN) systems is a plus
• Strong technical writing, data analysis, and communication skills

Summary:

We are seeking a highly motivated and detail-oriented Senior Associate Scientist (Contract) to join our Polysaccharide team. Primary responsibility for the incumbent will be to support analytical testing and characterization of polysaccharide-based drug candidates. This individual will execute and optimize a variety of biochemical and chromatographic assays, contribute to method development initiatives, and ensure high-quality data generation in support of research and development programs.  

This role requires strong hands-on experience in HPLC-based techniques, biochemical assays, and analytical software platforms, along with a commitment to data integrity, documentation excellence, and cross-functional collaboration.

Essential Functions: 

Analytical Testing & Characterization

• Perform in-house assays for polysaccharide manufacturing, including in-process testing, process development and process characterization study sample analysis, including:
• HPLC-based assays (e.g., HPLC-RI, HPAEC-PAD, etc.)
• Spectrophotometric-based assays (e.g., UV/Vis, Lowry, PicoGreen, Anthrone, etc.)
• Enzyme- and/or Immuno assays (e.g., ELISA, MSD platforms)
• Nephelometry (e.g. Turbidity analysis)
• Metabolite Analysis (e.g. sugars)
• LC-MS-based assay
• Prepare samples, reagents, standards, and controls according to established protocols.
• Troubleshoot instrumentation and assay performance issues to ensure reliable data output.

Method Development & Optimization

• Assist in developing, qualifying, and optimizing analytical methods for sample preparation, testing, and characterization.
• Support method transfer, robustness evaluation, and documentation updates.
• Proactively recommend improvements to increase assay sensitivity, reproducibility, and throughput.

Data Analysis & Reporting

• Utilize data analysis software platforms such as Empower and Chromeleon for HPLC data acquisition and analysis, and SoftMax Pro for MSD and spectrophotometric assay data analysis.
• Analyze, interpret, and summarize experimental data clearly and concisely.
• Prepare technical summaries and present findings to cross-functional teams (e.g., R&D, CMC, Quality).

Compliance & Documentation

• Maintain meticulous laboratory notebooks and electronic records in compliance with internal SOPs and laboratory standards.
• Ensure data integrity and adherence to applicable regulatory guidelines (e.g., GLP/GMP where applicable).
• Participate in audits, documentation reviews, and quality initiatives as needed.

Collaboration & Continuous Learning

• Collaborate effectively with scientists across disciplines to support program milestones.
• Demonstrate eagerness to learn new analytical techniques and scientific concepts.
• Integrate best laboratory practices and contribute to a culture of operational excellence.

Requirements:

• MSc in Chemistry/Biochemistry, Biotechnology, or similar degree with a minimum of 3 years of relevant industry experience, or BSc with a minimum of 5 years of relevant industry experience.
• Hands-on experience with HPLC systems and carbohydrate or polysaccharide analysis.
• Experience with HPAEC-PAD is preferred.
• Experience with LC-MS/MS is a plus.
• Experience with Empower and/or Chromeleon software.
• Familiarity with biochemical assays (ELISA, colorimetric, fluorescence-based assays).
• Experience working with polysaccharides, biologics, or complex drug substances.
• Experience in in-process monitoring and testing for process-related impurities.
• Knowledge of regulatory expectations for analytical documentation.
• Experience supporting CMC, process development, or analytical development programs.
• Strong organizational skills and attention to detail.
• Excellent written and verbal communication skills.
• Strong analytical and problem-solving skills.
• High attention to data accuracy and reproducibility.
• Ability to manage multiple priorities in a fast-paced environment.
• Collaborative team player with proactive communication style.
• Continuous improvement mindset.

Reports to: Senior Scientist, Polysaccharide Analytical Development

Location: San Carlos, CA

Expected Contract Length:
12months

Hourly Range: $56.00/hr. - $62.00/hr.

Summary:

Vaxcyte is seeking an Associate Scientist II (contract), Research, to support the research and development of a novel bacterial polysaccharide conjugate vaccine. Specifically, this role will contribute to the setup, synthesis, purification, and analytical characterization of chemically modified polysaccharides and polysaccharide-protein conjugates. 

The ideal candidate will have an excellent understanding of conjugation process development, analytical chemistry principles, and substantial hands-on laboratory experience. The successful candidate will be expected to independently optimize and troubleshoot upstream and downstream conjugation processing procedures with minimal guidance. The candidate will also contribute across a range of related areas, including analytical development, stability studies, and process optimization initiatives. Responsibilities will also include record management, presenting data at group meetings, and contributing to the authorship of laboratory protocols and development reports.

Essential Functions:

• Set up, optimize, and troubleshoot multi-step syntheses of protein-polysaccharide conjugates using click-chemistry and other related chemistries.
• Purify polysaccharides and conjugates using a variety of methods, including dialysis, FPLC chromatography, and tangential flow filtration (TFF).

• Characterize protein/polysaccharide/conjugates using different analytical methods, including SDS-PAGE gel, Western blotting, ELISA, HPLC, SEC-MALS, colorimetric and dynamic binding assays, et al.
• Apply Design of Experiments (DoE) principles; design, execute, and interpret statistically modeled experiments using DoE software.
• Proactively contribute scientific ideas, experimental strategies, and process improvements.
• Independently review and summarize relevant scientific literature to inform experimental design.
• Maintain highly organized records and Benchling entries to enable optimization and assessment of reproducibility.
• Analyze, interpret, and clearly communicate experimental data, including identifying trends, anomalies, and recommending next steps.
• Execute established protocols with limited oversight, demonstrating strong technical proficiency.
• Support team in routine laboratory activities and instrument maintenance.

Requirements: 

• BS. in Chemistry, Biochemistry, or related field or a related discipline, with minimum 2 years of relevant industry experience. MS without experience; or equivalent work experience.
• Strong understanding of underlying scientific concepts, process development, and analytical assay principles.
• Extensive hands-on experience in purification methods such as diafiltration, depth filters, and TFF (required).
• Prior hands-on experience in the conjugation process development is highly desirable.
• Proficiency with common protein/polysaccharide/conjugates analytical techniques, including SDS-PAGE, Western blotting, ELISA, HPLC, and SEC-MALS, is required
• Proven track record of developing scalable processes suitable for the pharma/Biotech industry.
• Experience with vaccines, carbohydrates, or protein is a plus.
• Attention to detail and excellent organizational skills.
• Ability to contribute to the overall lab management, including organization of vendors, service contracts, and equipment maintenance.
• Demonstrated success working in a cross-functional team environment.
• Strong interpersonal skills, with excellent written and verbal communication skills.

Summary:

Vaxcyte is seeking a talented and experienced Engineer I/II, to join the Upstream Process Development group within the Protein Development and CMC team. This is an exciting opportunity to join an outstanding team pursuing bacterial fermentation development at Vaxcyte.

The successful candidate will have the following skills and qualities:

• Hands-on experience operating and maintaining bioreactors, including Ambr® 250, at laboratory scale.
• Experience with pilot scale fermentation and recovery equipment is a plus.
• Skillful in analyzing and presenting data for process improvements, troubleshooting, and optimization.
• An exceptional team player who works seamlessly with others, speaks up, and remains focused on achieving the best results to achieve company goals.
• Strong organizational and planning skills.

Essential Functions:

• Lead operational activities related to bioreactor set-up, monitoring, harvest, and maintenance.
• Develop, test, and implement recipe scripting for fed-batch fermentation feeding controls.
• Provide engineering support for design, implementation, and qualification of scale-down models.
• Author SOPs (standard operating procedure), process flow diagrams and batch records.
• Analyze and present fermentation data at internal project meetings. Participate in upstream database management and documentation in electronic notebooks.

Requirements: 

• BS in Chemical Engineering or a related discipline with 8+ years, MS with 4+ years, or PhD with 0-2 years of relevant Pharma/Biotech industry experience.
• Hands-on experience with fermentation and/or primary recovery unit operations.
  • Good understanding in fundamentals of bioreactor design, operation and controls.
  • Strong knowledge of aseptic techniques
  • Mechanical and technical knowledge of primary recovery unit operations such as homogenization, centrifugation, and depth filtration, is a plus
  • Understanding of fermentation scale up and development of scale down models
• Familiarity with DoE (Design of Experiments) principles and software.
• Familiarity with regulatory requirements of biotherapeutics. Late-stage process characterization experience is a plus.

Summary:

Vaxcyte has an exciting opportunity for an energetic and talented individual to join our Analytical Development team. The Scientist I, Analytical Development, is responsible for executing analytical testing and contributing to analytical method development activities for biologics/vaccine development programs. 

This role performs routine and non-routine analytical assays using modern analytical techniques, supports method optimization and troubleshooting efforts, and contributes to continuous improvement initiatives with moderate supervision while partnering effectively with cross-functional teams. The position requires demonstrated hands-on laboratory experience, strong technical execution, and problem-solving skills, with the ability to independently plan and execute assigned work, analyze and interpret data, and escalate and/or drive investigations as needed. This role authors and maintains clear technical documentation, including method protocols, method development summaries, and SOPs, and communicates experimental results and conclusions to internal stakeholders.

Essential Functions:

Method Development & Troubleshooting

• Contribute to method development, optimization, and qualification/validation readiness activities.
• Design and execute experiments to evaluate critical method parameters and define appropriate system suitability and control strategies.
• Troubleshoot assay and instrument performance issues using a structured approach; interpret data to identify likely root causes, implement corrective actions, and document outcomes and recommendations.
• Support and/or execute method transfer activities, including protocol preparation, training support, execution at receiving labs, and resolution of transfer issues.
• Author and revise analytical methods, SOPs, protocols, and technical reports; ensure clear documentation of experimental rationale, results, and conclusions for internal review and stakeholder communication.

Team Collaboration

• Partner effectively with cross-functional teams to define analytical plans, meet project timelines, and deliver high-quality outputs.
• Communicate experimental progress, data interpretation, and emerging risks clearly; propose mitigation plans and align next steps with stakeholders.
• Contribute to a compliant, safety-focused, and scientifically rigorous lab culture, model good documentation practices and data integrity expectations.

Analytical Testing & Data Generation

• Perform routine and non-routine analytical testing using modern analytical methods (e.g., HPLC/UPLC, SEC, CE, UV-Vis, ELISA, electrophoresis, plate-based assays, and other biochemical/biophysical techniques).
• Execute assays in accordance with approved methods, SOPs, and applicable quality standards (GLP/GMP as applicable); identify and troubleshoot common issues.
• Perform data processing and interpretation; summarize results, trends, and potential risks, and escalate complex findings for review and decision-making.
• Maintain accurate, timely documentation in laboratory notebooks or electronic systems; contribute to clear technical communications to project and cross-functional stakeholders.

Laboratory Operations & Instrumentation

• Coordinate routine instrument maintenance and service activities; interface with vendors as needed and support timely issue resolution.
• Ensure laboratory organization, cleanliness, and compliant material labeling/storage practices.
• Manage inventory of reagents, standards, and consumables; initiate procurement, track critical supplies, and support forecasting to avoid stockouts.

Safety & Compliance

• Follow all Environmental Health & Safety (EHS) policies and laboratory safety practices.
• Handle chemicals and biological materials safely and in compliance with regulatory requirements.
• Ensure proper waste disposal and adherence to hazardous material handling procedures.
• Support audit and inspection readiness activities where applicable.

Requirements: 

PhD, MS or Bachelor’s degree in Chemistry, Biochemistry, Biology, Pharmaceutical Sciences, or a related scientific discipline. PhD with 1-2 years; MS with 5+ years; BS with 8+ years of relevant industry experience in analytical development, QC, or related field. Other combinations of education and/or experience may be considered.

• Strong hands-on experience with multiple analytical techniques, such as UV-Vis, HPLC, CE, SDS-PAGE, icIEF, Liquid chromatography, Mass Spectrometry, enzyme kinetics, colorimetric and fluorescent plate-based assays, ELISA, Western Blot, and PCR.
• Experience independently driving method development or optimization activities preferred.
• Strong knowledge of analytical chemistry/biochemistry principles with demonstrated application to assay development and control strategies.
• Proven ability to independently troubleshoot non-routine assay and instrument issues using structured root-cause analysis and data-driven decision making.
• Proficient in analytical software, data processing workflows, and statistical tools.
• Strong scientific judgment and attention to detail consistently produces high-quality, inspection-ready documentation.
• Ability to independently plan and prioritize work, manage multiple projects, and meet timelines with minimal supervision.
• Clear and effective written and verbal communication; able to summarize complex data, present recommendations, and collaborate across functions.

Summary:

Vaxcyte is looking for an energetic and talented individual to join our Drug Product Development team. The candidate must have knowledge of and practical experience in analyzing and characterizing biomolecules (proteins, polysaccharide conjugates, vaccines) using a variety of methods, especially immunoassays and multiplexed immunoassay formats. Experience in analyzing vaccine and adjuvant-containing formulations is a plus.

In addition, Vaxcyte is looking for an experienced and flexible individual who would be comfortable working on multiple projects at once, with fluid prioritization to enable aggressive timelines. This position is for a lab-based scientific role and requires excellent scientific judgement, independence, rigor, and thorough record-keeping.

Essential Functions:

• Execute routine and non-routine analysis of internal release, development, and stability samples using a variety of analytical techniques across Drug Product working groups, ensuring high-quality data generation and reporting.
• Support the execution, optimization, and continuous improvement of Vaxcyte’s internal multiplex immunoassay (MSD) assay suite, including troubleshooting assay performance, improving robustness, and supporting assay lifecycle management.
• Design, execute, and interpret experiments to support non-GxP stability studies including thermal, freeze/thaw, agitation, and container closure system evaluations for both Drug Substance and adjuvanted vaccine Drug Product materials.
• Analyze and interpret complex assay data, identify trends or deviations, and communicate findings to project teams to support development decisions.
• Contribute to method development, qualification, and technology transfer activities, including collaboration with external analytical laboratories and manufacturing CMOs.
• Author and review technical documentation including assay protocols, SOPs, reports, study plans, and technical summaries in support of development and analytical activities.
• Support the Vaxcyte PCV and VAXA1 programs through cross-functional collaboration with Drug Product Development, Formulation, Analytical Development, Quality, and external partners.
• Vaxcyte is seeking a flexible and collaborative Scientist comfortable managing multiple priorities in a fast-paced development environment.
• This role is predominantly lab-based and requires strong scientific judgment, independence in experimental execution, rigor in data analysis, and meticulous record keeping.

Requirements: 

• MS degree in Chemistry, Biochemistry, or related field with minimum 5 years of relevant industry experience, or BS degree with minimum 8 years of relevant industry experience.
• At least 2 years of experience in an analytical development or quality control role.
• Prior experience running colorimetric assays is required.
• Prior experience with SEC-MALS is required.
• Prior experience with SDS-PAGE is required.
• Excellent attention to detail, organizational skills, and record-keeping abilities.
• Ability to work both independently and collaboratively in a fast-paced environment.
• Commitment to integrity, professionalism, and safety in all aspects of work.

Hourly Range: $62.00/hr. - $68.00/hr.

Summary:

Vaxcyte’s Legal team is seeking a motivated, forward-thinking AI Consultant to support the design, evaluation, and implementation of emerging AI solutions across Legal and Compliance functions. This project-based role is ideal for a student pursuing their MS or PhD with strong technical skills, curiosity about legal operations, and a passion for applying AI to real-world business problems. You will work closely with cross-functional teams to prototype, test, and deploy AI tools that drive efficiency, enhance compliance workflows, and expand the team’s ability to deliver strategic support to the business.

Essential Functions:

• Bot Development: Design and prototype an AI-powered chatbot to support Legal and Compliance functions (e.g., FAQs, SOP references, or workflow routing).
• Legal Dashboard Enhancements: Enhance the existing Legal Dashboard using Box AI and related integrations to improve automation, visibility, and user experience.
• Tool Evaluation: Research, evaluate, and recommend emerging AI tools and products; schedule and participate in demos; provide post-demo analysis and recommendations.
• Implementation Support: Assist with tool rollout, user onboarding, and training materials for Legal, Compliance, and other stakeholders.
• Continuous Exploration: Identify and scope new AI use cases within Legal and related functions, collaborating with IT and Operations as needed.
• AI Tool Integration: Support implementation and optimization of existing Legal AI tools such as Spellbook and CoCounsel to ensure full functionality and adoption across teams.
• System Connectivity: Collaborate with IT to integrate and connect AI tools and software applications, enabling seamless read-only and action-based access across platforms. 

Requirements: 

• Enrolled in an MS or PhD program pursuing a degree in Computer Science, Data Science, Engineering, AI or a related field. 
• Strong understanding of generative AI concepts (e.g., open-source small LLMs, MCPRAG and API integrations).
• Excellent communication and analytical skills.
• Ability to translate technical concepts into practical applications for non-technical teams.
• Experience using or configuring AI tools such as Box AI, Microsoft Copilot, ChatGPT Enterprise, or similar platforms is preferred.
• Prior exposure to automation tools or workflow design (e.g., Power Automate, Zapier, or custom bots) is preferred.
• Demonstrated project management or client-facing experience (internships count!) is preferred.