Company Summary 

We are building a new venture, FL122, pioneering genomic technologies at the intersection of human health and assisted reproduction. The company was founded by Flagship Pioneering, an innovative enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Generate Biomedicines, Tessera Therapeutics, and Quotient Therapeutics. We are an equal opportunity employer. 

Position Summary 

We are seeking a Scientist with experience at the intersection of reproductive biology and molecular biology to help build the experimental foundation of the company’s scientific platform. As an early scientific team member, you will contribute to the development of core laboratory workflows spanning human gamete handling and molecular characterization, support the establishment of technical standards, and help execute the experimental strategy in close collaboration with senior scientists and leadership. 
 
We are looking for someone who is highly hands-on, adaptable, and excited to operate across disciplines. The ideal candidate brings a strong foundation from IVF or embryology laboratory environments, combined with experience in molecular biology techniques and a willingness to learn and implement new methods. This role requires attention to detail, comfort working with sensitive human samples, and a collaborative mindset suited for a fast-paced startup environment. 

Key Responsibilities 

• Perform and support IVF laboratory procedures, including preparation and handling of human gametes in a BSL2 environment with strict adherence to quality and reproducibility standards 

• Execute workflows related to ART techniques such as intra-cytoplasmic sperm injection (ICSI) and related embryology methods, contributing to protocol optimization and standardization 

• Conduct molecular biology experiments, including nucleic acid extraction, amplification, and QC from low-input or sensitive samples 

• Contribute to the development and optimization of workflows for integrating embryology procedures with downstream molecular analyses 

• Support implementation of instrumentation, reagents, and workflows to enable robust and scalable experimental operations 

• Assist in transcriptomic workflows (e.g., RNA-seq), including sample preparation, library preparation, and coordination with sequencing efforts 

• Analyze and communicate experimental results clearly, troubleshoot challenges, and iterate on protocols 

• Collaborate across internal teams and incorporate feedback from external advisors into experimental plans 

Requirements 

• Prior hands-on experience in IVF or embryology laboratory settings, including handling human gametes and performing procedures such as ICSI or related workflows  

• Ph.D. in biology, molecular biology, genetics, reproductive biology, or a related discipline strongly preferred; exceptional candidates with a Master’s degree/ relevant hands-on experience will also be considered  

• Strong foundation in molecular biology techniques, with demonstrated ability to learn and adapt to new experimental methods  

• Experience with RNA sequencing workflows; exposure to single-cell RNA sequencing is a plus but not required  

• Demonstrated ability to execute and troubleshoot experiments independently, particularly in low-input or sensitive sample contexts  

• High attention to detail and commitment to quality, especially when working with human-derived samples  

• Comfort working in a fast-moving, early-stage startup environment with a collaborative and proactive mindset 

At Flagship, we accept impossible missions to enable bigger leaps. Our core values guide us through uncertainty and toward lasting impact.

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other characteristic protected by law.

We recognize that great candidates often bring unique strengths without fulfilling every qualification. If you have some of the experience listed above but not all, please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your background and interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL122 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL122's good faith estimate as of the date of publication and may be modified in the future.

Company Summary:

Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

The role

We are seeking a highly innovative and driven Senior Scientist, Molecular Biology to lead the design and generation of next-generation DNA constructs enabling programmable medicines. This role is ideal for a scientist who thrives at the intersection of synthetic biology, high-throughput cloning, and computational sequence engineering.

You will play a critical role in building scalable platforms for plasmid DNA design, construction, and optimization, leveraging automation, algorithm-driven sequence design, and data-centric workflows. The ideal candidate brings deep technical expertise, creative problem-solving, and a passion for pushing the boundaries of nucleic acid engineering in a fast-paced, entrepreneurial environment.

The Senior Scientist will report to the Director of Molecular Biology and is expected to manage a direct report.  The role involves close collaboration with other Scientists and group leads across the company as part of a highly collaborative and growing R&D group.

Key responsibilities

• Lead the end-to-end design and construction of plasmid DNA constructs, including vector architecture, gene synthesis strategies, and high-efficiency cloning workflows (e.g., Gibson, Golden Gate, recombination-based methods).
• Drive automated and computational sequence design, utilizing advanced tools and pipelines for codon optimization, regulatory element tuning, and multi-parameter construct optimization.
• Establish vendor relationships with an emphasis on hybrid internal and external capabilities to remain agile while minimizing the impact on project timelines.
• Develop and implement variable-throughput cloning and screening platforms, standardized workflows, and scalable molecular biology processes.
• Own sequence analysis pipelines, variant analysis, and construct QC.
• Collaborate cross-functionally with diverse teams in the company. The ideal candidate will have a direct relationship with CMC. The chosen candidate will provide designs, material and timelines to CMC, as requested.
• Mentor and guide junior scientists, establishing best practices in molecular biology, experimental design, and data rigor.
• Establish a rigorous ELN environment including sample management, version-controlled sequence design, and reproducible research practices.
• Communicate scientific insights effectively, presenting results across functional teams and leadership to drive strategic decision-making.

Who you are

We encourage all candidates with exemplary experience in related fields to apply.

Technical Expertise

• PhD with 5+ years of relevant experience in relevant scientific discipline (Molecular Biology, Synthetic Biology, Bioengineering).
• Deep expertise in molecular cloning, plasmid design, DNA construct engineering, and E. coli strain engineering, including genetic modification and expression system development.
• Demonstrated experience with automated sequence design tools, scripting (e.g., Python), and/or computational biology workflows.
• Strong background in high-throughput and scalable molecular biology techniques.
• Experience with NGS data analysis and sequence validation pipelines.
• Familiarity with lab automation platforms and workflow integration is a plus.

Leadership & Collaboration

• Proven ability to lead complex projects and influence cross-functional teams.
• Strong mentorship skills with commitment to developing others. Previous technical or professional management experience.
• Excellent communication skills, with the ability to translate complex ideas across disciplines.

Values and Behaviors:

Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $126,000 - $181,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.

Company Summary:

Serif Biomedicines, Inc. is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies.

Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

The role

We are seeking an outstanding Research Associate, to join us in building the next generation of Programmable Medicines. We’re looking for a versatile molecular virologist / biochemist with experience in production and characterization of nucleic acids and in molecular cloning. We’re looking for an individual who brings scientific rigor, intellectual curiosity, enthusiasm, and a desire to innovate new nucleic acid therapeutics. This individual will have the opportunity to work in a dynamic and fast-paced entrepreneurial environment, working as part of a highly collaborative and growing team.

Key responsibilities

• Plasmid Production: Design, execute, and troubleshoot molecular cloning of inserts with varying lengths and compositions, ensuring accurate plasmid sequences.
• Inventory Management: Maintain organized storage of produced materials and keep detailed electronic records of material characteristics and storage locations.
• Enzymatic Reaction Optimization: Optimize and troubleshoot enzymatic reactions to enhance nucleic acid production and purity.
• Nucleic Acid Production: Follow and refine protocols to produce high-quality DNA and RNA with diverse expression cassettes.

Who you are

• Technical expert:
• You have 2+ years of industry experience, in immunology or biochemistry, and you’re experienced in nucleic acid and protein innovation, production, purification, and assay development. Or you have a master’s degree and 1+ years of experience in industry and want to be part of a dynamic team.
• Strong experience in independently designing and performing required experiments, as well as interpreting data and sharing results with the team.
• Strong, hands-on experience in cloning through multiple methods (e.g., Gibson, Golden Gate, etc.)
• Solid understanding of enzymatic reactions in nucleic acid synthesis and subsequent modifications.
• Deep understanding of enzymatic reactions involved in nucleic acid synthesis.

• You understand complex scientific concepts and can communicate technical information clearly, concisely, and decisively. Highly organized with strong attention to detail, you excel at systematically arranging and managing information and materials and can create and maintain electronic databases of materials produced, ensuring accessibility to other scientists.
• You flourish in collaborative work environments with other highly skilled individuals. You readily support your colleagues’ challenges and celebrate their victories.

Values and Behaviors:

Flagship is an experiment in institutional, entrepreneurial, and innovation practiced in the context of a small company with an insurgent mindset. We are seeking individuals with an entrepreneurial spirit, strong communication skills, and comfort in working in and contributing to a dynamic and cross-functional team environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, we encourage you to apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background. The level of the role will be commensurate with the education and years of experience of the identified candidates.

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $65,000 - $93,500. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. FL87 currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87's good faith estimate as of the date of publication and may be modified in the future.