Biohub
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Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our AI research team sits at the heart of our mission to unlock new dimensions of biological understanding. You will leverage state-of-the-art AI to accelerate discovery and drive transformative insights in biology — developing novel AI models purpose-built for biological research, engineering robust systems that enable breakthrough science at unprecedented scale, and translating these advances into practical tools that empower researchers worldwide.
Our approach is comprehensive and integrated, bringing together world-class AI model development, exceptional engineering talent, high-quality biological data, powerful computing infrastructure, and strategic partnerships. Success requires excellence across five interconnected pillars: training frontier AI models specifically for biology; building engineering systems that maximize research velocity and efficiency; executing a sophisticated data strategy that fuels AI development; operating a world-class AI compute platform; and creating impactful products that transform AI capabilities into accessible scientific tools.
The Opportunity
This is an opportunity to shape the future of biological research by pushing the boundaries of what AI can achieve in science. You’ll work alongside leading experts in AI and biology, with the resources and mandate to tackle some of the most important questions in human health — advancing frontier AI research, accelerating engineering velocity, connecting rich biological data to AI systems, enabling reliable compute across environments, and translating models and data into usable, scalable applications that drive scientific impact.
The role is part of the Data team, which focuses on owning the strategy, sourcing and implementation for data supporting AI research and development. We're a small team with significant resources and long time horizons. Our goal is to maximize the speed, agility, and capability of biological AI research by connecting public data resources and Biohub's experimental platforms to AI systems. The data that trains biological frontier models comes in dozens of modalities (sequences, images, spatial coordinates, time series, molecular structures, metadata, publication artifacts) each with its own noise characteristics, biases, and information content. The question of how to represent this data for learning is one of the most important open problems in biological AI.
We’re looking for a data scientist with deep expertise in genomics (e.g., bulk and single-cell sequencing, functional genomics, CRISPR screens), who thinks creatively about data representation and tokenization, and can translate that thinking into novel training architectures. You’ll work across experimental, computational, and AI teams to build scalable, interpretable genomic data systems that power next-generation biological models and accelerate human health discovery. You will operate with broad scope and high autonomy, influencing roadmap decisions across teams, and mentoring senior individual contributors. Success in this role means scaling data systems that are not only large, but adaptive, interpretable, and scientifically grounded, accelerating progress toward robust biological frontier models and ultimately advancing human health.
What You'll Do
- Set technical vision and strategy for the design of data representations and tokenization strategies for diverse biological data types that enable novel model architectures.
- Define data standards and quality metrics that enable reliable cross-dataset integration and model-ready data products.
- Develop and validate approaches for combining heterogeneous data modalities into unified training frameworks, designing for robustness to noise, bias, and batch effects
- Evaluate how representation choices impact model performance, identifying which biological signals are captured or lost and iterating to improve
- Partner deeply with ML engineers and AI researchers to co-design datasets and feedback loops that optimize model training, evaluation, and generalization.
- Lead cross-functional initiatives spanning data engineering, infrastructure, science, and product, aligning technical execution with long-term scientific goals.
- Identify and drive new data acquisition and generation opportunities, from external collaborations to internal experimental pipelines.
- Serve as a technical mentor and leader, raising the bar for data science and ML rigor across the organization.
What You'll Bring
- PhD in computational biology, bioinformatics, or a quantitative biological field
- 8+ years of experience working with large-scale biological datasets (genomics, epigenomics, transcriptomics, proteomics, or multi-omics), including ownership of end-to-end data products.
- Deep understanding of biological measurement types (sequencing, imaging, proteomics, or related), their underlying data characteristics, and how to transform raw data into ai-ready datasets.
- Experience designing data representations or feature engineering for machine learning in biomedical contexts
- Strong computational skills (Python, scientific computing libraries); Demonstrated ability to design robust, extensible data architectures and to evolve standards in fast-moving scientific domains.
- Strong expertise in machine learning and statistical modeling, with experience applying these methods to data quality assessment, automation, or decision-making systems. Familiarity with modern ML architectures (transformers, diffusion models, or similar) and how data representation choices affect learning
- Excellent communication skills, with the ability to translate between biology, ML, and engineering audiences.
- Creativity, Curiosity, scientific judgment, and a willingness to engage deeply with new biological domains and emerging AI paradigms.
Compensation
The Redwood City, CA base pay range for a new hire in this role is $214,000 - $294,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Hybrid
Ready to apply?
Apply to Biohub
Staff Data Scientist, Reasoning
Share this job
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our AI research team sits at the heart of our mission to unlock new dimensions of biological understanding. You will leverage state-of-the-art AI to accelerate discovery and drive transformative insights in biology—developing novel AI models purpose-built for biological research, engineering robust systems that enable breakthrough science at unprecedented scale, and translating these advances into practical tools that empower researchers worldwide.
Our approach is comprehensive and integrated, bringing together world-class AI model development, exceptional engineering talent, high-quality biological sciences and data, powerful computing infrastructure, and strategic partnerships. Success requires excellence across five interconnected pillars: training frontier AI models specifically for biology; building engineering systems that maximize research velocity and efficiency; executing a sophisticated biological and data strategy that fuels AI development; operating a world-class AI compute platform; and creating impactful products that transform AI capabilities into accessible scientific tools.
The Opportunity
This is an opportunity to shape the future of biological research by pushing the boundaries of what AI can achieve in science. You’ll work alongside leading experts in AI and biology, with the resources and mandate to tackle some of the most important questions in human health — advancing frontier AI research, accelerating engineering velocity, connecting rich biological data to AI systems, enabling reliable compute across environments, and translating models and data into usable, scalable applications that drive scientific impact.
The role is part of the Data team, which is responsible for maximizing the speed, agility, and capability of biological AI research by connecting public data resources and Biohub's experimental platforms to AI systems. The data that trains biological frontier models comes in dozens of modalities (sequences, images, spatial coordinates, time series, molecular structures, metadata, publication artifacts, …) each with its own noise characteristics, biases, and information content. The question of how AI can reason across these diverse descriptions of biology to answer specific experimental questions is one of the core challenges in biology.
You will define the data approach to train our reasoning system. To do so, you will operate with broad scope and high autonomy, influencing roadmap decisions across teams while mentoring individual contributors. Success in this role means scaling data systems that are not only large, but adaptive, interpretable, and scientifically grounded, accelerating progress toward robust biological frontier models and ultimately advancing human health. We're looking for data scientists who can work at this frontier: people who understand scientific experimentation deeply, think creatively about data representations and tokenization strategies, and have experience building reasoning systems. You'll work directly with experimental and computational scientists, data scientists and AI researchers to define what the models see and how they see it, and data engineers to make this work at scale. This is a role for someone who wants to invent the methods that make biological frontier models possible.
What You'll Do
- Design reasoning tasks for our models.
- Build training datasets that capture biology experiments, including experimental design, hypothesis generation, evidence interpretation, and scientific inference
- Design training strategies that teach reasoning capabilities, working closely with AI Research to translate data approaches into model behavior
- Create evaluation and benchmarking frameworks that measure reasoning quality and analyze model behavior to influence the next set of evaluations, environments, and data.
- Partner with Scientific Data Strategy and Data Engineering to identify and acquire source materials (literature, protocols, experimental records) that contain reasoning signal
- Set technical direction for reasoning data efforts, influencing priorities and mentoring other data scientists working in this area
What You'll Bring
- PhD in machine learning, computational biology, or another quantitative field
- Hands on understanding of how scientists reason across diverse experimental systems as obtained from hands-on experience with laboratory science in biology, biochemistry, or chemistry
- Experience curating or creating training data and tokenization strategies for reasoning models (RLVR, synthetic reasoning traces, RL with Tool Use)
- Track record of novel methodological contributions (publications, open-source tools, or production systems)
- Familiarity with evaluation methodology for complex, open-ended tasks where ground truth is ambiguous
- Strong computational skills (Python, data processing at scale); ability to work with large text corpora and structured data
- Creative, first-principles thinking about how to structure data for learning
Compensation
The Redwood City, CA & New York City, NY base pay range for a new hire in this role is $214,000 - $268,000. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Hybrid
Ready to apply?
Apply to Biohub
Biohub is the first large-scale initiative bringing frontier AI models, massive compute, and frontier experimental capabilities under one roof. We're building a general-purpose system to accelerate scientific discovery, integrating frontier AI models, biological foundation models, and lab capabilities, with the ultimate goal of curing disease. Our technology powers scientists around the world, translating AI capabilities into tools that accelerate research everywhere.
The Team
Our AI research team sits at the heart of our mission to unlock new dimensions of biological understanding. You will leverage state-of-the-art AI to accelerate discovery and drive transformative insights in biology—developing novel AI models purpose-built for biological research, engineering robust systems that enable breakthrough science at unprecedented scale, and translating these advances into practical tools that empower researchers worldwide.
Our approach is comprehensive and integrated, bringing together world-class AI model development, exceptional engineering talent, high-quality biological data, powerful computing infrastructure, and strategic partnerships. Success requires excellence across five interconnected pillars: training frontier AI models specifically for biology; building engineering systems that maximize research velocity and efficiency; executing a sophisticated data strategy that fuels AI development; operating a world-class AI compute platform; and creating impactful products that transform AI capabilities into accessible scientific tools.
The Opportunity
This role is part of the Data team, which focuses on owning the strategy, sourcing and implementation for data supporting AI research and development. Our goal is to maximize the speed, agility, and capability of biological AI research by connecting public data resources and Biohub's experimental platforms to AI systems.
The data that trains biological frontier models comes in dozens of modalities—sequences, images, spatial coordinates, time series, molecular structures, metadata, preprints and published papers—each with its own noise characteristics, biases, and information content. The question of how to represent this data for learning is one of the most important open problems in biological AI.
You will operate with broad scope and high autonomy, influencing roadmap decisions across teams while mentoring senior individual contributors. Success in this role means scaling data systems that are not only large, but adaptive, interpretable, and scientifically grounded, accelerating progress toward robust biological frontier models and ultimately advancing human health.
We're looking for data scientists who can work at this frontier: people who understand biological measurement deeply, think creatively about data representations and tokenization strategies, and can translate that thinking into novel training architectures. You'll work directly with experimental and computational scientists, data scientists and AI researchers to define what the models see and how they see it, and data engineers to make this work at scale. This is a role for someone who wants to invent the methods that make biological frontier models possible.
What You'll Do
-
Design data representations and tokenization strategies for imaging data that enable novel model architectures
-
Coordinate Experimental, Data Science, Data Engineering and AI Research teams to translate biological structure into learnable representations—defining priorities and appropriate structures for metadata and data that information models can access and consume
-
Work across those teams to guide data acquisition priorities, define quality criteria, and assess external datasets from a representation perspective
-
Develop and validate approaches for combining heterogeneous data modalities into unified training frameworks, designing for robustness to noise, bias, and batch effects
-
Evaluate how representation choices impact model performance, identifying which biological signals are captured or lost and iterating to improve
What You'll Bring
- PhD in computational biology, bioinformatics, or a quantitative biological field
- Experience with tokenization strategies for non-text data (images, sequences, graphs, time series)
- Track record of novel methodological contributions (publications, open-source tools, or production systems)
- Familiarity with biological foundation models (ESM, scGPT, or similar)
- Deep understanding of imaging data, their underlying data characteristics, and how to transform raw data into ai-ready datasets.
- Experience designing data representations or feature engineering for machine learning, ideally in scientific or biological contexts
- Familiarity with modern ML architectures (transformers, diffusion models, or similar) and how data representation choices affect learning
- Strong computational skills (Python, scientific computing libraries); comfort working with large-scale datasets
- Creative, first-principles thinking about how to structure data for learning
Compensation
The Redwood City, CA base pay range for a new hire in this role is $214,000 - $294,800. New hires are typically hired into the lower portion of the range, enabling employee growth in the range over time. Actual placement in range is based on job-related skills and experience, as evaluated throughout the interview process.
This position may be eligible to participate in Biohub's discretionary annual performance bonus program. Bonus eligibility and targets are determined in accordance with Biohub's total rewards philosophy and may vary by role.
Better Together
As we grow, we’re excited to strengthen in-person connections and cultivate a collaborative, team-oriented environment. This role is a hybrid position requiring you to be onsite for at least 60% of the working month, approximately 3 days a week, with specific in-office days determined by the team’s manager. The exact schedule will be at the hiring manager's discretion and communicated during the interview process.
Benefits for the Whole You
We’re thankful to have an incredible team behind our work. To honor their commitment, we offer a wide range of benefits to support the people who make all we do possible.
- Provides a generous employer match on employee 401(k) contributions to support planning for the future.
- Paid time off to volunteer at an organization of your choice.
- Funding for select family-forming benefits.
- Relocation support for employees who need assistance moving
If you’re interested in a role but your previous experience doesn’t perfectly align with each qualification in the job description, we still encourage you to apply as you may be the perfect fit for this or another role.
#LI-Hybrid
Ready to apply?
Apply to Biohub